{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T19:18:44Z","timestamp":1759778324058},"reference-count":31,"publisher":"Japan Society of Histochemistry & Cytochemistry","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Histochem. Cytochem.","Acta Histochemica et Cytochemica","Acta Histochem. Cytochem"],"published-print":{"date-parts":[[2013]]},"DOI":"10.1267\/ahc.12033","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T22:37:29Z","timestamp":1357857449000},"page":"25-34","source":"Crossref","is-referenced-by-count":7,"title":["Induction of \u03b2-Defensin Expression by &lt;i&gt;Porphyromonas gingivalis&lt;\/i&gt;-Infected Human Gingival Graft Transplanted in &lt;i&gt;nu\/nu&lt;\/i&gt; Mouse Subdermis"],"prefix":"10.1267","volume":"46","author":[{"given":"Masahiro","family":"To","sequence":"first","affiliation":[{"name":"Department of Environmental Pathology and Research Institute of Salivary Gland Health Medicine, Kanagawa Dental College Postgraduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Kamata","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Dentistry, Yokohama Clinic, Kanagawa Dental College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juri","family":"Saruta","sequence":"additional","affiliation":[{"name":"Department of Environmental Pathology and Research Institute of Salivary Gland Health Medicine, Kanagawa Dental College Postgraduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Environmental Pathology and Research Institute of Salivary Gland Health Medicine, Kanagawa Dental College Postgraduate School"},{"name":"Department of Comprehensive Dentistry, Yokohama Clinic, Kanagawa Dental College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takenori","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Infection Control, Division of Microbiology, Kanagawa Dental College Postgraduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Environmental Pathology and Research Institute of Salivary Gland Health Medicine, Kanagawa Dental College Postgraduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Environmental Pathology and Research Institute of Salivary Gland Health Medicine, Kanagawa Dental College Postgraduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobushiro","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Infection Control, Division of Microbiology, Kanagawa Dental College Postgraduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Tsukinoki","sequence":"additional","affiliation":[{"name":"Department of Environmental Pathology and Research Institute of Salivary Gland Health Medicine, Kanagawa Dental College Postgraduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"334","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-007-0381-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0904-2512.2004.00143.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08302.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Chung, W. O., Hansen, S. R., Rao, D. and Dale, B. A. (2004) Protease-activated receptor signaling increases epithelial antimicrobial peptide expression. J. Immunol. 173; 5165-5170.","DOI":"10.4049\/jimmunol.173.8.5165"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2001.360503.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300901.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00211.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1267\/ahc.10029"},{"key":"9","unstructured":"9. Hioki, K., Kuramochi, T., Endoh, S., Terada, E., Ueyama, Y. and Ito, M. (2001) Lack of B cell leakiness in BALB\/cA-nu, scid double mutant mice. Exp. Anim. 50; 67-72."},{"key":"10","unstructured":"10. Holmstrup, P., Stoltze, K., Bretlau, P. and Dabelsteen, E. (1981) Human buccal mucosa transplants in nude mice. Scand. J. Dent. Res. 89; 89-96."},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1267\/ahc.10027"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.5.2907-2915.2000"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Mahanonda, R., Sa-Ard-Iam, N., Eksomtramate, M., Rerkyen, P., Phairat, B., Schaecher, K. E., Fukuda, M. M. and Pichyangkul, S. (2009) Cigarette smoke extract modulates human &beta;-defensin-2 and interleukin-8 expression in human gingival epithelial cells. J. Periodontal Res. 44; 557-564.","DOI":"10.1111\/j.1600-0765.2008.01153.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23705.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Nakajima, K., Hamada, N., Takahashi, Y., Sasaguri, K., Tsukinoki, K., Umemoto, T. and Sato, S. (2006) Restraint stress enhances alveolar bone loss in an experimental rat model. J. Periodontal Res. 41; 527-534.","DOI":"10.1111\/j.1600-0765.2006.00901.x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Pihlstrom, B. L., Michalowicz, B. S. and Johnson, N. W. (2005) Periodontal diseases. Lancet 366; 1809-1820.","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"17","unstructured":"17. Pivarcsi, A., Bodai, L., R&eacute;thi, B., Kenderessy-Szab&oacute;, A., Koreck, A., Sz&eacute;ll, M., Beer, Z., Bata-Cs&ouml;rgoo, Z., Mag&oacute;csi, M., Rajnav&ouml;lgyi, E., Dobozy, A. and Kem&eacute;ny, L. (2003) Expression and function of Toll-like receptors 2 and 4 in human keratinocytes. Int. Immunol. 15; 721-730."},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.03.016"},{"key":"19","unstructured":"19. Romano-Carratelli, C., Mazzola, N., Paolillo, R., Sorrentino, S. and Rizzo, A. (2009) Toll-like receptor-4 (TLR4) mediates human &beta;-defensin-2 (HBD-2) induction in response to Chlamydia pneumoniae in mononuclear cells. FEMS Immunol. Med. Microbiol. 57; 116-124."},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1267\/ahc.12005"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Schenkein, H. A. (2006) Host responses in maintaining periodontal health and determining periodontal disease. Periodontol. 2000 40; 77-93.","DOI":"10.1111\/j.1600-0757.2005.00144.x"},{"key":"22","unstructured":"22. Sugai, J., Iizuka, M., Kawakubo, Y., Ozawa, A., Ohkido, M., Ueyama, Y., Tamaoki, N., Inokuchi, S. and Shimamura, K. (1998) Histological and immunocytochemical studies of human psoriatic lesions transplanted onto SCID mice. J. Dermatol. Sci. 17; 85-92."},{"key":"23","unstructured":"23. Sun, Y., Shu, R., Zhang, M. Z. and Wu, A. P. (2008) Toll-like receptor 4 signaling plays a role in triggering periodontal infection. FEMS Immunol. Med. Microbiol. 52; 362-369."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Taguchi, Y. and Imai, H. (2006) Expression of &beta;-defensin-2 in human gingival epithelial cells in response to challenge with Porphyromonas gingivalis in vitro. J. Periodontal Res. 41; 334-339.","DOI":"10.1111\/j.1600-0765.2006.00879.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Takizawa, Y., Saida, T., Tokuda, Y., Dohi, S., Ikegawa, S. and Ueyama, Y. (1995) Engraftment of precursor lesions of human cutaneous neoplasms onto C.B-17 SCID mice: a useful in vivo experimental model of carcinogenesis in human skin. Arch. Dermatol. Res. 287; 237-241.","DOI":"10.1007\/BF01105072"},{"key":"26","unstructured":"26. Takizawa, Y., Saida, T., Tokuda, Y., Dohi, S., Wang, Y. L., Urano, K., Hioki, K. and Ueyama, Y. (1997) New immunodeficient (nude-scid, beige-scid) mice as excellent recipients of human skin grafts containing intraepidermal neoplasms. Arch. Dermatol. Res. 289; 213-218."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Tsukinoki, K., Miyoshi, Y., Aoki, T., Karakida, K., Ohta, Y., Kaneko, A., Ueyama, Y. and Watanabe, Y. (2007) In vivo experimental model of human gingival mucosa using immunodeficient mice. J. Periodontal Res. 42; 294-299.","DOI":"10.1111\/j.1600-0765.2006.00947.x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Vardar-Sengul, S., Demirci, T., Sen, B. H., Erkizan, V., Kurulgan, E. and Baylas, H. (2007) Human b defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases. J. Periodontal Res. 42; 429-437.","DOI":"10.1111\/j.1600-0765.2006.00964.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-009-0780-4"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Vora, P., Youdim, A., Thomas, L. S., Fukata, M., Tesfay, S. Y., Lukasek, K., Michelsen, K. S., Wada, A., Hirayama, T., Arditi, M. and Abreu, M. T. (2004) &beta;-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J. Immunol. 173; 5398-5405.","DOI":"10.4049\/jimmunol.173.9.5398"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Zhang, Z., Jin, L., Champion, G., Seydel, K. B. and Stanley, S. L. Jr. (2001) Shigella infection in a SCID mouse-human intestinal xenograft model: role for neutrophils in containing bacterial dissemination in human intestine. Infect. Immun. 69; 3240-3247.","DOI":"10.1128\/IAI.69.5.3240-3247.2001"}],"container-title":["ACTA HISTOCHEMICA ET CYTOCHEMICA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ahc\/46\/1\/46_12033\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T06:35:22Z","timestamp":1616999722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ahc\/46\/1\/46_12033\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1267\/ahc.12033","relation":{},"ISSN":["0044-5991","1347-5800"],"issn-type":[{"value":"0044-5991","type":"print"},{"value":"1347-5800","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}