{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:37:27Z","timestamp":1777729047937,"version":"3.51.4"},"reference-count":37,"publisher":"Japan Society of Histochemistry & Cytochemistry","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Histochemica et Cytochemica","Acta Histochem. Cytochem","Acta Histochem. Cytochem."],"published-print":{"date-parts":[[2017]]},"DOI":"10.1267\/ahc.17004","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T22:09:41Z","timestamp":1498082981000},"page":"111-118","source":"Crossref","is-referenced-by-count":15,"title":["Expression of c-kit and Cytokeratin 5 in the Submandibular Gland after Release of Long-Term Ligation of the Main Excretory Duct in Mice"],"prefix":"10.1267","volume":"50","author":[{"given":"Hiroshi","family":"Watanabe","sequence":"first","affiliation":[{"name":"Course of Clinical Science, Field of Oral and Maxillofacial Surgery and Systemic Medicine, Oral and Maxillofacial Surgery, The Nippon Dental University Graduate School of Life Dentistry at Niigata"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Life Dentistry, The Nippon Dental University at Niigata"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Hata-Kawakami","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Life Dentistry, The Nippon Dental University at Niigata"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Life Dentistry, The Nippon Dental University at Niigata"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"334","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Akadomari, K., Tanaka, A. and Mataga, I. (2016) Regenerative capacity of atrophic submandibular gland by duct ligation in mice. J. Hard Tissue Biol. 25; 121\u2013130.","DOI":"10.2485\/jhtb.25.121"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Bozorgi, S. S., Proctor, G. B. and Carpenter, G. H. (2014) Rapamycin delays salivary gland atrophy following ductal ligation. Cell Death Dis. 27; e1146.","DOI":"10.1038\/cddis.2014.108"},{"key":"3","unstructured":"3 B\u00f6cker, W., B\u00fcrger, H., Buchwalow, I. B. and Decker, T. (2005) Ck5-positive cells are precursor cells of glandular and myoepithelial cell lineages in the human breast epithelium. A new concept as a basis for a better understanding of proliferative breast disease? Verh. Dtsch. Ges. Pathol. 89; 45\u201347."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Cotroneo, E., Proctor, G. B., Paterson, K. L. and Carpenter, G. H. (2008) Early markers of regeneration following ductal ligation in rat submandibular gland. Cell Tissue Res. 332; 227\u2013235.","DOI":"10.1007\/s00441-008-0588-6"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Cotroneo, E., Proctor, G. B., Paterson, K. L. and Carpenter, G. H. (2010) Regeneration of acinar cells following ligation of rat submandibular gland retraces the embryonic-perinatal pathway of cytodifferentiation. Differentiation 79; 120\u2013130.","DOI":"10.1016\/j.diff.2009.11.005"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6 Haara, O., Koivisto, T. and Miettinen, P. J. (2009) EGF-receptor regulates salivary gland branching morphogenesis by supporting proliferation and maturation of epithelial cells and survival of mesenchymal cells. Differentiation 77; 298\u2013306.","DOI":"10.1016\/j.diff.2008.10.006"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Hai, B., Yang, Z., Millar, S. E., Choi, Y. S., Taketo, M. M., Nagy, A. and Liu, F. (2010) Wnt\/\u03b2-catenin signaling regulates postnatal development and regeneration of the salivary gland. Stem Cells Dev. 19; 1793\u20131801.","DOI":"10.1089\/scd.2009.0499"},{"key":"8","unstructured":"8 Hipkaeo, W., Chomphoo, S., Pakkarato, S., Sakaew, W., Sawatpanich, T., Hozumi, Y., Polsan, Y., Hipkaeo, D., Goto, K. and Kondo, H. (2015) Selective localization of diacylglycerol kinase (DGK)\u03b6 in the terminal tubule cells in the submandibular glands of early postnatal mice. Histochem. Cell Biol. 144; 185\u2013193."},{"key":"9","doi-asserted-by":"publisher","unstructured":"9 Hisatomi, Y., Okumura, K., Nakamura, K., Matsumoto, S., Satoh, A., Nagano, K., Yamamoto, T. and Endo, F. (2004) Flow cytometric isolation of endodermal progenitors from mouse salivary gland differentiate into hepatic and pancreatic lineages. Hepatology 39; 667\u2013675.","DOI":"10.1002\/hep.20063"},{"key":"10","unstructured":"10 Jaskoll, T. and Melnick, M. (1999) Submandibular gland morphogenesis: stage-specific expression of TGF-alpha\/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat. Rec. 256; 252\u2013268."},{"key":"11","unstructured":"11 Kawakami, M., Ishikawa, H., Tanaka, A. and Mataga, I. (2016) Induction and differentiation of adipose-derived stem cells from human buccal fat pads into salivary gland cells. Hum. Cell 29; 101\u2013110."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Kim, H. Y. and Nelson, C. M. (2012) Extracellular matrix and cytoskeletal dynamics during branching morphogenesis. Organogenesis 8; 56\u201364.","DOI":"10.4161\/org.19813"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Larsen, H. S., Aure, M. H., Peters, S. B., Larsen, M., Messelt, E. B. and Galtung, H. K. (2011) Localization of AQP5 during development of the mouse submandibular salivary gland. J. Mol. Histol. 42; 71\u201381.","DOI":"10.1007\/s10735-010-9308-0"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Lennartsson, J. and Ronnstrand, L. (2012) Stem cell factor receptor\/c-Kit: from basic science to clinical implications. Physiol. Rev. 92; 1619\u20131649.","DOI":"10.1152\/physrev.00046.2011"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Lombaert, I. M., Brunsting, J. F., Wierenga, P. K., Faber, H., Stokman, M. A., Kok, T., Visser, W. H., Kampinga, H. H., de Haan, G. and Coppes, R. P. (2008) Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS One 3; e2063.","DOI":"10.1371\/journal.pone.0002063"},{"key":"16","unstructured":"16 Matsuzaki, T., Susa, T., Shimizu, K., Sawai, N., Suzuki, T., Aoki, T., Yokoo, S. and Takata, K. (2012) Function of the membrane water channel aquaporin-5 in the salivary gland. Acta Histochem. Cytochem. 45; 251\u2013259."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Murayama, K., Kawakami, M. and Tanaka, A. (2017) Chronic changes in the atrophied submandibular gland after long-term ligation of the main excretory duct in mice. J. Hard Tissue Biol. 26; 13\u201322.","DOI":"10.2485\/jhtb.26.13"},{"key":"18","unstructured":"18 Nagai, K., Arai, H., Okudera, M., Yamamura, T., Oki, H. and Komiyama, K. (2014) Epiregulin is critical for the acinar cell regeneration of the submandibular gland in a mouse duct ligation model. J. Oral Pathol. Med. 43; 378\u2013387."},{"key":"19","unstructured":"19 Nanduri, L. S., Maimets, M., Pringle, S. A., van der Zwaag, M., van Os, R. P. and Coppes, R. P. (2011) Regeneration of irradiated salivary glands with stem cell marker expressing cells. Radiother. Oncol. 99; 367\u2013372."},{"key":"20","unstructured":"20 Nanduri, L. S., Lombaert, I. M., van der Zwaag, M., Faber, H., Brunsting, J. F., van Os, R. P. and Coppes, R. P. (2013) Salisphere derived c-Kit<sup>+<\/sup> cell transplantation restores tissue homeostasis in irradiated salivary gland. Radiother. Oncol. 108; 458\u2013463."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Rebustini, I. T., Hayashi, T., Reynolds, A. D., Dillard, M. L., Carpenter, E. M. and Hoffman, M. P. (2012) miR-200c regulates FGFR-dependent epithelial proliferation via Vldlr during submandibular gland branching morphogenesis. Development 139; 191\u2013202.","DOI":"10.1242\/dev.070151"},{"key":"22","unstructured":"22 Scott, J., Liu, P. and Smith, P. M. (1999) Morphological and functional characteristics of acinar atrophy and recovery in the duct-ligated parotid gland of the rat. J. Dent. Res. 78; 1711\u20131719."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Shimizu, O., Yasumitsu, T., Shiratsuchi, H., Oka, S., Watanabe, T., Saito, T. and Yonehara, Y. (2015) Immunolocalization of FGF-2, -7, -8, -10 and FGFR-1-4 during regeneration of the rat submandibular gland. J. Mol. Histol. 46; 421\u2013429.","DOI":"10.1007\/s10735-015-9631-6"},{"key":"24","unstructured":"24 Sumita, Y., Liu, Y., Khalili, S., Maria, O. M., Xia, D., Key, S., Cotrim, A. P., Mezey, E. and Tran, S. D. (2011) Bone marrow-derived cells rescue salivary gland function in mice with head and neck irradiation. Int. J. Biochem. Cell Biol. 43; 80\u201387."},{"key":"25","unstructured":"25 Susa, T., Sawai, N., Aoki, T., Iizuka-Kogo, A., Kogo, H., Negishi, A., Yokoo, S., Takata, K. and Matsuzaki, T. (2013) Effects of repeated administration of pilocarpine and isoproterenol on aquaporin-5 expression in rat salivary glands. Acta Histochem. Cytochem. 46; 187\u2013197."},{"key":"26","unstructured":"26 Takahashi, S. and Wakita, M. (1993) Regeneration of the intralobular duct and acinus in rat submandibular glands after YAG laser irradiation. Arch. Histol. Cytol. 56; 199\u2013206."},{"key":"27","unstructured":"27 Takahashi, S., Schoch, E. and Walker, N. I. (1998) Origin of acinar cell regeneration after atrophy of the rat parotid induced by duct obstruction. Int. J. Exp. Pathol. 79; 293\u2013301."},{"key":"28","unstructured":"28 Takahashi, S., Shinzato, K., Nakamura, S., Domon, T., Yamamoto, T. and Wakita, M. (2004) Cell death and cell proliferation in the regeneration of atrophied rat submandibular glands after duct ligation. J. Oral Pathol. Med. 33; 23\u201329."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Takahashi-Horiuchi, Y., Sugiyama, K., Sakashita, H. and Amano, O. (2008) Expression of heat shock protein 27 with the transition from proliferation to differentiation of acinar precursor cell in regenerating submandibular gland of rats. Tohoku J. Exp. Med. 214; 221\u2013230.","DOI":"10.1620\/tjem.214.221"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Takeyama, A., Yoshikawa, Y., Ikeo, T., Morita, S. and Hieda, Y. (2015) Expression patterns of CD66a and CD117 in the mouse submandibular gland. Acta Histochem. 117; 76\u201382.","DOI":"10.1016\/j.acthis.2014.11.004"},{"key":"31","unstructured":"31 Tamarin, A. (1971) Submaxillary gland recovery from obstruction. I. Overall changes and electron microscopic alterations of granular duct cells. J. Ultrastruct. Res. 34; 276\u2013287."},{"key":"32","unstructured":"32 Tamarin, A. (1971) Submaxillary gland recovery from obstruction. II. Electron microscopic alterations of acinar cells. J. Ultrastruct. Res. 34; 288\u2013302."},{"key":"33","unstructured":"33 Ueda, J., Iwai, T., Ozawa, T., Oguri, S., Mitsudo, K. and Tohnai, I. (2016) Endoscopic removal of submandibular gland stone in a child: a case report. Jpn. J. Oral Maxillofac. Surg. 62; 575\u2013578."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Wang, X., Qi, S., Wang, J., Xia, D., Qin, L., Zheng, Z., Wang, L., Zhang, C., Jin, L., Ding, G., Wang, S. and Fan, Z. (2014) Spatial and temporal expression of c-Kit in the development of the murine submandibular gland. J. Mol. Histol. 45; 381\u2013389.","DOI":"10.1007\/s10735-014-9570-7"},{"key":"35","unstructured":"35 Yagishita, H., Uchida, M. and Aiyama, S. (2001) Histological changes in the rat submandibular gland following ligation and removal of the main excretory duct. Jpn. J. Oral Biol. 43; 676\u2013689."},{"key":"36","unstructured":"36 Yamagishi, R., Wakayama, T., Nakata, H., Adthapanyawanich, K., Kumchantuek, T., Yamamoto, M. and Iseki, S. (2014) Expression and localization of \u03b1-amylase in the submandibular and sublingual glands of mice. Acta Histochem. Cytochem. 47; 95\u2013102."},{"key":"37","unstructured":"37 Yamamoto, M., Nakata, H., Kumchantuek, T., Sakulsak, N. and Iseki, S. (2016) Immunohistochemical localization of keratin 5 in the submandibular gland in adult and postnatal developing mice. Histochem. Cell Biol. 145; 327\u2013339."}],"container-title":["Acta Histochemica et Cytochemica","ACTA HISTOCHEMICA ET CYTOCHEMICA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ahc\/50\/3\/50_17004\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T13:43:08Z","timestamp":1569505388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ahc\/50\/3\/50_17004\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1267\/ahc.17004","relation":{},"ISSN":["0044-5991","1347-5800"],"issn-type":[{"value":"0044-5991","type":"print"},{"value":"1347-5800","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}