{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:13Z","timestamp":1772168833529,"version":"3.50.1"},"reference-count":33,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Training Health Researchers into Vocational Excellence","award":["Grant number 087540"],"award-info":[{"award-number":["Grant number 087540"]}]}],"content-domain":{"domain":["aasopenresearch.org"],"crossmark-restriction":false},"short-container-title":["AAS Open Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Human African Trypanosomiasis (HAT) is fatal if untreated; the drugs to treat it are toxic making its management difficult and diagnosis complex. Nwoya district has a long history of sleeping-sickness dating back to pre-colonial times. The civil war of 1986-2008 displaced many who upon return complained of cattle and dogs dying of unknown causes alongside increased tsetse flies infestation hence, the needs for the study.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    We enrolled local 3,040 pupils and recorded their social-demographic characteristics and access to different domesticated animals\/fowls in their homes. Screening for HAT using the card agglutination test for trypanosomiasis (CATT) was performed; positive individuals had their titres determined, followed by microscopy and loop mediated isothermal amplification analysis (LAMP). R was used for analysis where associations were sought between dependent and independent variables. Any factor with P-value &lt;0.05 was taken as statistically significant.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    HAT serological prevalence of 1.2% (95% CI 0.8-1.6) was obtained, 58.3% being boys while 41.7% were girls with titres ranging from 1:2 - 1:16. Two schools alone, constituted 47% of the CATT positive cases.\n                  <\/ns4:p>\n                  <ns4:p>\n                    Pupils who came from homes with dogs were more likely to be CATT\/\n                    <ns4:italic>Trypanosoma brucei gambiense<\/ns4:italic>\n                    positive; (adjusted odds ratio = 3.12, 95% CI 1.41-6.99 &amp; p=0.005).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    Though no parasites were detected, with prevalence of CATT positive at 1.2%, active surveillance in the district is still recommended.\u00a0CATT positive cases needs follow-ups were immune trypanolysis test done to ascertain their exposure.\n                  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Bargul, Department of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya, 30 Apr 2018, version 1, indexed","URL":"https:\/\/aasopenresearch.org\/articles\/1-8\/v1#referee-response-26364","order":0,"name":"referee-response-26364","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/aasopenres.13917.r26362, Mike Brown, London School of Hygiene & Tropical Medicine, London, UK, 30 Apr 2018, version 1, indexed","URL":"https:\/\/aasopenresearch.org\/articles\/1-8\/v1#referee-response-26362","order":1,"name":"referee-response-26362","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/aasopenres.13917.r26363, Jos\u00e9 R. Franco, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, World Health Organization, Geneva, Switzerland, 08 May 2018, version 1, indexed","URL":"https:\/\/aasopenresearch.org\/articles\/1-8\/v1#referee-response-26363","order":2,"name":"referee-response-26363","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/aasopenres.13917.r26327, Enock Matovu, Department of Biotechnology and Diagnostic Sciences, College of Veterinary medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda, 08 May 2018, version 1, indexed","URL":"https:\/\/aasopenresearch.org\/articles\/1-8\/v1#referee-response-26327","order":3,"name":"referee-response-26327","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This research was supported by Training Health Researchers into Vocational Excellence (THRiVE) in East Africa, grant number 087540, funded by the Wellcome Trust. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}