{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:33:39Z","timestamp":1780054419489,"version":"3.54.0"},"update-to":[{"DOI":"10.12688\/aasopenres.13022.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000}}],"reference-count":35,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Africa Research Excellence Fund","award":["MRF-157-0007-F-BADU"],"award-info":[{"award-number":["MRF-157-0007-F-BADU"]}]},{"name":"KNUST College of Science"}],"content-domain":{"domain":["aasopenresearch.org"],"crossmark-restriction":false},"short-container-title":["AAS Open Res"],"abstract":"<ns5:p>\n                    <ns5:bold>Background:<\/ns5:bold>\n                    Toxoplasma gondii is an obligate, intracellular, apicomplexan parasite that causes toxoplasmosis. Although the global prevalence of toxoplasmosis has been estimated to be approximately 30%, there is limited seroprevalence data in Ghana, with a dearth of information on the impact of T. gondii on haematological parameters in exposed persons.\n                  <\/ns5:p>\n                  <ns5:p>\n                    <ns5:bold>Methods:<\/ns5:bold>\n                    Questionnaires were administered to 300 consenting individuals to obtain demographic information and assessment of their risk of exposure to\n                    <ns5:italic>T. gondii<\/ns5:italic>\n                    . Using anti-\n                    <ns5:italic>T. gondii<\/ns5:italic>\n                    IgG\/IgM combo test kits, seropositivity to parasite-specific IgG and\/or IgM was determined. A haematological analyser was used to measure haematological parameters.\n                  <\/ns5:p>\n                  <ns5:p>\n                    <ns5:bold>Results:<\/ns5:bold>\n                    There was an overall seroprevalence of 50.3% (n=151), with 49.7% (n=149) of the study participants seropositive for IgG and 1% (n=3) testing positive for IgM. Furthermore, the observed seroprevalence among pregnant women was 56.4% (n=62). With regard to settlement type, a seroprevalence of 55.6% was observed in the rural community, 50.6% in the peri-urban community and 47.1% in the urban community. The study identified cat ownership, contact with cat litter, contact with raw meat\u00a0 [RR (95% CI: 1.76 (1.23-2.53), 1.66 (1.03-2.67), 1.25(1.00-1.57)] and age (p&lt;0.001) as risk factors for infection. Analyses of haematological data revealed significant reduction in the white blood cell, lymphocytes and mean corpuscular volume levels in seropositive males (p=0.0223, 0.0275, and 0.0271) respectively. Only the mean corpuscular volume of seropositive females reduced significantly as compared to the seronegative counterparts (p=0.0035).\u00a0\n                  <\/ns5:p>\n                  <ns5:p>\n                    <ns5:bold>Conclusions:<\/ns5:bold>\n                    About half of the study population, including women of reproductive age carried antibodies against\n                    <ns5:italic>T. gondii<\/ns5:italic>\n                    , raising concerns about the risk of congenital toxoplasmosis and anaemia. We, therefore, recommend that screening for\n                    <ns5:italic>Toxoplasma gondii<\/ns5:italic>\n                    be included in the routine screening of pregnant women seeking antenatal care and further investigation should be conducted on the haematological implications of infection in humans.\n                  <\/ns5:p>","DOI":"10.12688\/aasopenres.13022.2","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T06:25:37Z","timestamp":1592375137000},"page":"166","update-policy":"https:\/\/doi.org\/10.12688\/aasopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Seroprevalence, risk factors and impact of Toxoplasma gondii infection on haematological parameters in the Ashanti region of Ghana: a cross-sectional study"],"prefix":"10.12688","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-2841","authenticated-orcid":false,"given":"Samuel Kekeli","family":"Agordzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7886-5528","authenticated-orcid":false,"given":"Kingsley","family":"Badu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew Glover","family":"Addo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2947-9775","authenticated-orcid":false,"given":"Christian Kwasi","family":"Owusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-6823","authenticated-orcid":false,"given":"Abdul-Hakim","family":"Mutala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austine","family":"Tweneboah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawood Ackom","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0961-4434","authenticated-orcid":false,"given":"Nana Kwame","family":"Ayisi-Boateng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"1257-78","DOI":"10.1016\/j.ijpara.2008.03.007","article-title":"Toxoplasma gondii infection in humans and animals in the United States.","volume":"38","author":"J Dubey","year":"2008","journal-title":"Int J Parasitol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1965-76","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis.","volume":"363","author":"J Montoya","year":"2004","journal-title":"Lancet."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"757-60","DOI":"10.1093\/schbul\/sbl074","article-title":"Effects of Toxoplasma on human behavior.","volume":"33","author":"J Flegr","year":"2007","journal-title":"Schizophr 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KB received funds for laboratory supplies from the Africa Research Excellence Fund (AREF) Research Development Fellowship [MRF-157-0007-F-BADU]. Kingsley Badu is an Affiliate of the African Academy of Sciences (2017-2022). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}