{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:29:50Z","timestamp":1777436990478,"version":"3.51.4"},"reference-count":7,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T00:00:00Z","timestamp":1350604800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>This is a case report of a 29-year-old Saudi male with sickle cell disease (SCD) with severe stiffness of his joints, mainly both knees and hips, secondary to complications of SCD. He was severely crippled: unable to sit, stand or walk, and was bedridden for 8 years when he was presented to us. Radiographs showed fusion of both knees and hips. There was no evidence of active osteomyelitis by Gallium scan. The patient\u2019s hemoglobin S decreased to levels below 30% by exchange transfusion. Bilateral total hip replacement, as well as unilateral total knee replacement, was carried out to improve his level of function. There is only one reported case of such severe and multiple joint complications in a single patient suffering from SCD.<\/ns4:p>\n                  <ns4:p>The increased life expectancy that medical advances have offered to the sickle-cell patients has led to the appearance of sickle-cell-related complications, which were previously only seen rarely. These complications were successfully managed and the patient was able to move and transfer using a wheel chair.<\/ns4:p>","DOI":"10.12688\/f1000research.1-32.v1","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T12:28:59Z","timestamp":1368102539000},"page":"32","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Ankylosis of the hips and knees due to sickle cell disease"],"prefix":"10.12688","volume":"1","author":[{"given":"Saad Saleh Abdullah","family":"Al Elayan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Al Hamdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2012,10,19]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"480-7","DOI":"10.2471\/BLT.06.036673","article-title":"Global epidemiology of haemoglobin disorders and derived service indicators.","volume":"86","author":"B Modell","year":"2008","journal-title":"Bull World Health Organ."},{"key":"ref-2","doi-asserted-by":"crossref","first-page":"384-97","DOI":"10.1097\/00006416-200311000-00004","article-title":"Perioperative care for patients with sickle cell who are undergoing total hip replacement as treatment for osteonecrosis.","volume":"22","author":"M Hammer","year":"2003","journal-title":"Orthop Nurs."},{"key":"ref-3","doi-asserted-by":"crossref","first-page":"307-10","DOI":"10.1007\/BF00182718","article-title":"Orthopaedic complications in sickle cell disease. A comparative study from two regions in Saudi Arabia.","volume":"16","author":"M Sadat-Ali","year":"1992","journal-title":"Int Orthop."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"287-90","DOI":"10.1007\/s100670070047","article-title":"A \u2018made in one piece\u2019 skeleton in a 22-years-old man suffering from sickle cell anaemia.","volume":"19","author":"N Dumarey","year":"2000","journal-title":"Clin Rheumatol."},{"key":"ref-5","doi-asserted-by":"crossref","first-page":"766-85","DOI":"10.1097\/00000542-200409000-00027","article-title":"Sickle cell disease and anesthesia.","volume":"101","author":"P Firth","year":"2004","journal-title":"Anesthesiology."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"1005-12","DOI":"10.1302\/0301-620X.90B8.20552","article-title":"The safety and efficacy of bilateral simultaneous total hip replacement. An analysis of 2063 cases.","volume":"90","author":"E Tsiridis","year":"2008","journal-title":"J Bone Joint Surg Br."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"668-73","DOI":"10.1302\/0301-620X.90B5.19937","article-title":"Conversion of bilateral hip and knee ankylosis to total joint replacements.","volume":"90","author":"A Karva","year":"2008","journal-title":"J Bone Joint Surg Br."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/1-32\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/1-32\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/1-32\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T06:15:48Z","timestamp":1543558548000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/1-32\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,19]]},"references-count":7,"URL":"https:\/\/doi.org\/10.12688\/f1000research.1-32.v1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.204.r320","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.204.r322","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.204.r322","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.204.r320","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,19]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/1-32\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.204.r320, Maria Luisa Brandi, Department of Internal Medicine, University of Florence, Viale Morgagni, Florence, Italy, 25 Oct 2012, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/1-32\/v1#referee-response-320","order":0,"name":"referee-response-320","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.204.r322, Adlette Inati, Division of Pediatric Hematology and Oncology, Children's Center for Cancer and Blood Diseases, Rafik Hariri University Hospital, Beirut, Lebanon, 29 Nov 2012, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/1-32\/v1#referee-response-322","order":1,"name":"referee-response-322","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}