{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:16:45Z","timestamp":1790824605372,"version":"4.1.0"},"reference-count":47,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Youth Innovation Promotion Association from the Chinese Academy of Sciences.","award":["2016235"],"award-info":[{"award-number":["2016235"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"crossref","award":["14XD1404500"],"award-info":[{"award-number":["14XD1404500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81373307 and 81202442"],"award-info":[{"award-number":["81373307 and 81202442"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Bacterial aromatic polyketides, exemplified by anthracyclines, angucyclines, tetracyclines, and pentangular polyphenols, are a large family of natural products with diverse structures and biological activities and are usually biosynthesized by type II polyketide synthases (PKSs). Since the starting point of biosynthesis and combinatorial biosynthesis in 1984\u20131985, there has been a continuous effort to investigate the biosynthetic logic of aromatic polyketides owing to the urgent need of developing promising therapeutic candidates from these compounds. Recently, significant advances in the structural and mechanistic identification of enzymes involved in aromatic polyketide biosynthesis have been made on the basis of novel genetic, biochemical, and chemical technologies. This review highlights the progress in bacterial type II PKSs in the past three years (2013\u20132016). Moreover, novel compounds discovered or created by genome mining and biosynthetic engineering are also included.<\/ns4:p>","DOI":"10.12688\/f1000research.10466.1","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T11:25:25Z","timestamp":1487676325000},"page":"172","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":74,"title":["New insights into bacterial type II polyketide biosynthesis"],"prefix":"10.12688","volume":"6","author":[{"given":"Zhuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Xue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3149-4683","authenticated-orcid":false,"given":"Gong-Li","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"631-9","DOI":"10.1021\/ar8002249","article-title":"Biosynthesis of aromatic polyketides in bacteria.","volume":"42","author":"A Das","year":"2009","journal-title":"Acc Chem Res."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"839-68","DOI":"10.1039\/b911518h","article-title":"Cyclization of aromatic polyketides from bacteria and 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.11276.r19863, Ikuro Abe, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan, 21 Feb 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-172\/v1#referee-response-19863","order":0,"name":"referee-response-19863","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.11276.r19864, Yi Tang, University of California, Los Angeles, CA, USA, 21 Feb 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-172\/v1#referee-response-19864","order":1,"name":"referee-response-19864","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"We thank the National Natural Science Foundation of China (81373307 and 81202442), the Science and Technology Commission of Shanghai Municipality (14XD1404500), and the Youth Innovation Promotion Association (2016235) from the Chinese Academy of Sciences for our supporting grants. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}