{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:40:52Z","timestamp":1777480852339,"version":"3.51.4"},"reference-count":10,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004508","name":"Prince of Songkla University","doi-asserted-by":"publisher","award":["55-021-01-1-2"],"award-info":[{"award-number":["55-021-01-1-2"]}],"id":[{"id":"10.13039\/501100004508","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    The metered-dose inhalers (MDIs) currently available for inhaled corticosteroid delivery do not offer an integrated dose counter; therefore, it is difficult to evaluate adherence of patients. The present authors developed a linear regression equation using canister weight to calculate the number of doses actuated from the MDIs. This study aimed to assess medical adherence after the integration of regular weighing of the canisters into the routine service.\u00a0\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    A cohort study was carried out between May 2013 and April 2014. Children aged less than 8 years with a diagnosis of asthma were recruited. The duration of adherence assessment was 24 weeks. Participants had a regular schedule every 8 weeks to obtain a new FLIXOTIDE\u00ae 125 inhaler. Parents were asked to collect the discarded MDI canisters, which were then weighed by a laboratory scale. The weight of each canister was replaced in the regression equation to calculate the number of doses actuated from the MDIs.\u00a0\n                    <ns4:bold>Results:<\/ns4:bold>\n                    A total of 52 asthmatic children participated in the study. The median age was 52.7 months. At the end of 24 weeks, 44, 33, and 23 discarded MDI canisters were collected from visits 1, 2, and 3, respectively. The median percentages of adherence were 96.8%, 96.3%, and 96.3%, respectively. In 11 discarded canisters (11%), the remaining medication was more than 30% of the labeled doses. Approximately 90% of the participants had no asthma exacerbation during 24-week study period.\u00a0\n                    <ns4:bold>Conclusion:<\/ns4:bold>\n                    High adherence rates were achieved after integration of canister weighing into the asthma care service.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.10710.1","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T10:05:49Z","timestamp":1489485949000},"page":"266","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Achieving good adherence to inhaled corticosteroids after weighing canisters of asthmatic children"],"prefix":"10.12688","volume":"6","author":[{"given":"Wantida","family":"Chuenjit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vorapan","family":"Engchuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araya","family":"Yuenyongviwat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2295-533X","authenticated-orcid":false,"given":"Pasuree","family":"Sangsupawanich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"1417-25","DOI":"10.1185\/03007995.2014.908827","article-title":"Impact of adherence to treatment with fluticasone propionate\/salmeterol in asthma patients.","volume":"30","author":"A Ismaila","year":"2014","journal-title":"Curr Med Res Opin."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"105-6","DOI":"10.1111\/j.1440-1843.2005.00629.x","article-title":"Metered dose inhalers: a need for dose counters.","volume":"10","author":"S Holt","year":"2005","journal-title":"Respirology."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"1458-62","DOI":"10.1111\/j.1398-9995.2009.02037.x","article-title":"Monitoring adherence to beclomethasone in asthmatic children and adolescents through four different methods.","volume":"64","author":"N Jentzsch","year":"2009","journal-title":"Allergy."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"AB41","DOI":"10.1016\/j.jaci.2011.12.817","article-title":"Relationship of canister weight to the amount of medication actuated from metered-dose inhalers","volume":"129","author":"T Sahajarupat","year":"2012","journal-title":"J Allergy Clin Immunol."},{"key":"ref-5","article-title":"Global Strategy for Asthma Management and Prevention"},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"AB179","DOI":"10.1016\/j.jaci.2013.12.640","article-title":"Medication Remaining In Discarded Metered Dose Inhalers Of Asthmatic Children","volume":"133","author":"W Dampanrat","year":"2014","journal-title":"J Allergy Clin Immunol."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"784-9","DOI":"10.1111\/j.1398-9995.2008.01877.x","article-title":"Adherence rate to inhaled corticosteroids and their impact on asthma control.","volume":"64","author":"L Lasmar","year":"2009","journal-title":"Allergy."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"338-43","DOI":"10.1016\/j.rmed.2011.12.001","article-title":"Adherence rate to beclomethasone dipropionate and the level of asthma control.","volume":"106","author":"N Jentzsch","year":"2012","journal-title":"Respir Med."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"416-21","DOI":"10.1016\/S1081-1206(10)62557-4","article-title":"Measurement of children's asthma medication adherence by self report, mother report, canister weight, and Doser CT.","volume":"85","author":"B Bender","year":"2000","journal-title":"Ann Allergy Asthma Immunol."},{"key":"ref-10","doi-asserted-by":"publisher","DOI":"10.5256\/f1000research.10710.d150970","article-title":"Dataset 1 in: Achieving good adherence to inhaled corticosteroids after weighing canisters of asthmatic children.","author":"W Chuenjit","year":"2017","journal-title":"F1000Research."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/6-266\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/6-266\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/6-266\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T10:23:31Z","timestamp":1544091811000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/6-266\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":10,"URL":"https:\/\/doi.org\/10.12688\/f1000research.10710.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.11547.r24513","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.11547.r21967","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.11547.r22150","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.11547.r21967","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.11547.r22150","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.11547.r24513","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/6-266\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.11547.r21967, Wiparat Manuyakorn, Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 21 Apr 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-266\/v1#referee-response-21967","order":0,"name":"referee-response-21967","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.11547.r22150, Bee Wah Lee, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 24 Apr 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-266\/v1#referee-response-22150","order":1,"name":"referee-response-22150","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.11547.r24513, Orathai Piboonpocanun, \u00a0Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, 09 Aug 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-266\/v1#referee-response-24513","order":2,"name":"referee-response-24513","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The study was funded by Faculty of Medicine, Prince of Songkla University (55-021-01-1-2). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}