{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:06:39Z","timestamp":1772168799117,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.109221.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000}}],"reference-count":14,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background:<\/ns3:bold>\n                    Human bocavirus (HBoV) is a viral pathogen from the genus\n                    <ns3:italic>Bocaparvovirus<\/ns3:italic>\n                    (family\n                    <ns3:italic>Parvoviridae<\/ns3:italic>\n                    , subfamily\n                    <ns3:italic>Parvovirinae<\/ns3:italic>\n                    ) discovered in 2005. Most of available literature is about HBoV in children and adults with hematological malignancies and in otherwise healthy children with respiratory infections. Information regarding infection in the adult population with solid tumors is scarce.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Case Report:<\/ns3:bold>\n                    We report the case of a 51-year-old male with metastatic castration resistant prostate cancer undergoing chemotherapy treatment who presented with fever, dyspnea, dry cough, and pleuritic pain. Imaging techniques showed signs of congestive heart failure. Symptoms, laboratory tests and echocardiography revealed a more probable infectious etiology. Antibiotic therapy was started. A polymerase chain reaction (PCR) test of nasopharyngeal exudate for respiratory viruses was positive for HBoV. The rest of the microbiological tests were negative. Bronchoalveolar lavage (BAL) was performed. Bacterial culture of BAL was negative while respiratory virus PCR confirmed positivity for HBoV. Antibiotic therapy was discontinued. The patient gradually recovered.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusions:<\/ns3:bold>\n                    Emerging infectious diseases are a notorious threat for immunocompromised populations such as solid tumor patients. This case is unique because to our knowledge this is the first case report article of HBoV in a solid tumor patient and because imaging techniques exhibited signs of congestive heart failure that did not correlate with the rest of the tests. It shows that unusual pathogens should be considered when managing serious clinical complications with uncommon presentations in cancer patients. Notable diagnostic efforts should be made to reach a diagnosis in these cases.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.109221.2","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T05:50:57Z","timestamp":1648533057000},"page":"196","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Bocavirus Infection Radiologically Resembling a Congestive Heart Failure in a Patient with Metastatic Castration-Resistant Prostate Cancer"],"prefix":"10.12688","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8827-2497","authenticated-orcid":false,"given":"Javier David","family":"Benitez Fuentes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"de Luna Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma","family":"Flores Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Lopez de Sa Lorenzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Toledano Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berta","family":"Laguna Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3625-8228","authenticated-orcid":false,"given":"Richa","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Frick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro Francisco","family":"Jimenez Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Rocha I\u00f1igo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Vidal Cassinello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3-12","DOI":"10.3390\/v1010003","article-title":"Human bocavirus - insights into a newly identified respiratory virus.","volume":"1","author":"J L\u00fcsebrink","year":"2009 Jun","journal-title":"Viruses."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"12891-12896","DOI":"10.1073\/pnas.0504666102","article-title":"Cloning of a human parvovirus by molecular screening of respiratory tract samples.","volume":"102","author":"T Allander","year":"2005 Sep 6","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.14233","article-title":"Prevalence of human bocavirus infections in Europe. A systematic review and meta-analysis.","author":"D Polo","year":"2021 Jul 12","journal-title":"Transbound. Emerg. Dis."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"20246","DOI":"10.1038\/srep20246","article-title":"Clinical significance of different virus load of human bocavirus in patients with lower respiratory tract infection.","volume":"6","author":"W Jiang","year":"2016 Feb","journal-title":"Sci. Rep."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"158-162","DOI":"10.1016\/j.jcv.2010.07.016","article-title":"Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection.","volume":"49","author":"A Christensen","year":"2010 Nov","journal-title":"J. Clin. Virol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e2019006","DOI":"10.4084\/MJHID.2019.006","article-title":"Respiratory Viral Infections in Children and Adolescents with Hematological Malignancies.","volume":"11","author":"S Han","year":"2019 Jan 1","journal-title":"Mediterr J. Hematol. Infect. Dis."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"3294","DOI":"10.3389\/fmicb.2018.03294","article-title":"Respiratory Virus Infections in Hematopoietic Cell Transplant Recipients.","volume":"9","author":"C Pochon","year":"2019 Jan","journal-title":"Front. Microbiol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1425-1427","DOI":"10.3201\/eid1309.070318","article-title":"Disseminated bocavirus infection after stem cell transplant.","volume":"13","author":"T Schenk","year":"2007 Sep","journal-title":"Emerg. Infect. Dis."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"226-228","DOI":"10.3201\/eid2701.202061","article-title":"Severe Human Bocavirus-Associated Pneumonia in Adults at a Referral Hospital, Seoul, South Korea.","volume":"27","author":"S Choi","year":"2021 Jan","journal-title":"Emerg. Infect. Dis."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"635-640","DOI":"10.3892\/ol.2012.548","article-title":"High prevelance of human parvovirus infection in patients with malignant tumors.","volume":"3","author":"Y Li","year":"2012 Mar","journal-title":"Oncol. Lett."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1226-1235","DOI":"10.3348\/kjr.2018.0634","article-title":"Human Bocavirus Infection in Adults: Clinical Features and Radiological Findings.","volume":"20","author":"H Lee","year":"2019 Jul","journal-title":"Korean J. Radiol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"801-810","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).","volume":"315","author":"M Singer","year":"2016 Feb 23","journal-title":"JAMA."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"891-975","DOI":"10.1002\/ejhf.592","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.","volume":"18","author":"P Ponikowski","year":"2016 Aug","journal-title":"Eur. J. Heart Fail."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"242-250","DOI":"10.1016\/j.ejca.2020.06.001","article-title":"SARS-CoV-2 infection in cancer patients undergoing active treatment: analysis of clinical features and predictive factors for severe respiratory failure and death.","volume":"135","author":"R Yarza","year":"2020 Aug","journal-title":"Eur. J. Cancer."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-196\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-196\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-196\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T04:30:13Z","timestamp":1650429013000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-196\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":14,"URL":"https:\/\/doi.org\/10.12688\/f1000research.109221.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.122669.r129133","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.122669.r129132","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.122669.r129132","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.122669.r129133","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,29]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-196\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.122669.r129133, Macarena Torrego-Ellacur\u00eda, Department of Endocrinology and Nutrition, Hospital Cl\u00ednico San Carlos, IdISSC, Madrid, Spain, 29 Mar 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-196\/v2#referee-response-129133","order":0,"name":"referee-response-129133","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.122669.r129132, Marcos Roberto Tovani Palone, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil, 20 Apr 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-196\/v2#referee-response-129132","order":1,"name":"referee-response-129132","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}