{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:06:16Z","timestamp":1772168776267,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.110022.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000}}],"reference-count":16,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Cardiac metastases are rare. Herein, we report a case of a 37-year-old female patient with a history of borderline breast phyllodes tumor (PT) treated by surgery, admitted to our department for concomitant cardiac and pulmonary metastases of malignant PT. Cardiac metastasis occurred through direct extension from pulmonary metastasis to the left atrium via the right inferior pulmonary vein, causing severe mitral valve obstruction. Although the total surgical removal of metastases, the patient had a huge relapse of the mediastinal metastasis resulting in her death.<\/ns4:p>","DOI":"10.12688\/f1000research.110022.2","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T11:25:08Z","timestamp":1658748308000},"page":"309","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Mitral valve obstruction by metastatic malignant phyllodes tumor"],"prefix":"10.12688","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9745-5041","authenticated-orcid":false,"given":"Chamtouri","family":"Ikram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amdouni","family":"Nesrine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0287-1689","authenticated-orcid":false,"given":"Kaddoussi","family":"Rania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahlem","family":"Bellalah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kortas","family":"Chokri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-1743","authenticated-orcid":false,"given":"Achour","family":"Asma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joober","family":"Sameh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maatouk","family":"Faouzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"428-435","DOI":"10.1136\/pmj.77.909.428","article-title":"Phyllodes tumors.","volume":"77","author":"S Parker","year":"2001","journal-title":"Postgrad. Med. J."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e13767","DOI":"10.1097\/MD.0000000000013767","article-title":"Phyllodes tumor of the breast with nipple discharge: A case report.","volume":"97","author":"P Jing","year":"2018","journal-title":"Medicine (Baltimore)."},{"key":"ref3","first-page":"665-671","article-title":"PhyllodesTumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular\/Genetic Updates.","volume":"140","author":"Y Zhang","year":"2016","journal-title":"ArchPatholLab Med."},{"key":"ref4","first-page":"187-193","article-title":"Cystosarcoma phyllodes. Diagnosis and management.","volume":"4","author":"J Rosenfeld","year":"1981","journal-title":"Cancer Clin. Trials."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"408-417","DOI":"10.1002\/path.2439","article-title":"mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours.","volume":"216","author":"A Jones","year":"2008","journal-title":"Phyllodes. Tumour Consortium. J. Pathol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"27-34","DOI":"10.1136\/jcp.2005.035105","article-title":"Cardiac metastases.","volume":"60","author":"R Bussani","year":"2007","journal-title":"J. Clin. Pathol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"324-330","DOI":"10.6004\/jnccn.2007.0027","article-title":"Phyllodes tumors of the breast: natural history, diagnosis, and treatment.","volume":"5","author":"M Telli","year":"2007","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"131-147","DOI":"10.1002\/jso.2930040208","article-title":"Metastatic cystosarcoma phyllodes: a case report and review of the literature.","volume":"4","author":"A Kessinger","year":"1972","journal-title":"J. Surg. Oncol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"657-670","DOI":"10.1016\/S0733-8651(18)30717-3","article-title":"Cardiac effects of non cardiac neoplasms.","volume":"2","author":"F Schoen","year":"1984","journal-title":"Cardiol. Clin."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"423-426","DOI":"10.1007\/s11748-009-0556-4","article-title":"Pulmonary artery obstruction due to a metastatic malignant phyllodes tumor of the breast.","volume":"58","author":"T Nakatsu","year":"2010","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"key":"ref11","first-page":"441-444","article-title":"Delayed cardiac metastasis from phyllodes breast tumor presenting as cardiogenic shock.","volume":"38","author":"N Garg","year":"2011","journal-title":"Tex Heart Inst. J."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"439-449","DOI":"10.1148\/radiographics.21.2.g01mr15439","article-title":"Metastatic involvement of the heart and pericardium: CT and MR imaging.","volume":"21","author":"C Chiles","year":"2001","journal-title":"Radiographics."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1680-1683","DOI":"10.1111\/echo.14120","article-title":"Treatment of recurrent isolated right atrial metastatic cavitary mass frombreast cancer with radiation therapy: A case report and review of literature.","volume":"35","author":"L Ya'qoub","year":"2018","journal-title":"Echocardiography."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s40792-015-0121-6","article-title":"Malignant phyllodes tumor metastasized to the right ventricle: a case report.","volume":"1","author":"F Yoshidaya","year":"2015","journal-title":"Surg. Case Rep."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"889-894","DOI":"10.1067\/mtc.2002.121493","article-title":"Cardiomyoplasty:ventricular reconstruction after tumor resection.","volume":"123","author":"J Chachques","year":"2002","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"450-454","DOI":"10.1136\/jclinpath-2013-202118","article-title":"Cardio pulmonary thrombo embolism of epithelioid angiosarcoma arising from malignant phyllodes tumour of the breast.","volume":"67","author":"C Goh","year":"2014","journal-title":"J. Clin. Pathol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-309\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-309\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-309\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T07:55:37Z","timestamp":1665561337000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-309\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,25]]},"references-count":16,"URL":"https:\/\/doi.org\/10.12688\/f1000research.110022.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.136136.r145275","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.136136.r145275","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,25]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-309\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.121589.r139615, Hassen Ibn Hadj Amor, Taher Sfar university hospital, Mahdia, Tunisia, 15 Jun 2022, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/11-309\/v1#referee-response-139615","order":0,"name":"referee-response-139615","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.136136.r145275, Chien-Liang Fang, Division of Plastic and Reconstruction Surgery, Department of Surgery, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan, 02 Aug 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-309\/v2#referee-response-145275","order":1,"name":"referee-response-145275","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}