{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:19:41Z","timestamp":1793272781967,"version":"4.5.0"},"update-to":[{"DOI":"10.12688\/f1000research.110072.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000}},{"DOI":"10.12688\/f1000research.110072.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000}},{"DOI":"10.12688\/f1000research.110072.3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000}}],"reference-count":21,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The author(s) declared that no grants were involved in supporting this work."}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background<\/ns4:bold>\n                    : Prostate cancer is a disease that occurs in men aged more than 50 years. In Iraq, 8.89 men per 100,000 population suffer from prostate cancer, with the incidence being 14,016 cases and mortality being 6,367 cases. Despite advances in treatment against prostate cancer, it can become resistant to drugs. Therefore, the aim of current study was to search and identify binding sites for the repositioning of drugs by computational methods (docking).\u00a0\n                    <ns4:bold>Methods<\/ns4:bold>\n                    : Based on the protein structure of the wild androgen receptor, the analysis parameters (22x22x22 on the X, Y, and Z axes) were established.\n                    <ns4:bold>Results<\/ns4:bold>\n                    : The interactions of the natural ligands with androgen receptor were 10.0 (testosterone) and 10.8 (dihydrotestosterone) while mutated androgen receptor (T877A) had a low affinity with testosterone and dihydrotestosterone (-5.3 and -6.7, respectively). In the interactions of both receptors with the reported inhibitors (antagonists), a decrease with Bicalutamide (-8.3 and -4.3, respectively) and an increase in affinity with Flutamide and Nilutamide (-7.7 and 8.6, wild AR; -8.7 and -9.3 AR T877A) were observed. As for Enzalutamide and Apalutamide (second-generation antagonists), the change was minimal between wild androgen receptor and T877A (-7.6 and -7.7; -7.3 and -7.3, respectively). The change in the affinity of the ligands with androgen receptor and androgen receptor T877A shows how a mutation alters the bonds between these molecules.\n                    <ns4:bold>Conclusion<\/ns4:bold>\n                    : The identification of key sites and potent inhibitors against abnormal androgen receptor functions will enrich prostate cancer treatments.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.110072.4","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T10:20:09Z","timestamp":1704968409000},"page":"516","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["In silico comparison between the mutated and wild-type androgen receptors and their influence on the selection of optimum androgenic receptor blockers for the treatment of prostate cancer"],"prefix":"10.12688","volume":"11","author":[{"given":"Mohammed J.","family":"AL-Zobaidy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Akeel Al-Hussaniy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahraa","family":"S. Al-tameemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e295-e300","DOI":"10.18295\/squmj.2020.20.03.008","article-title":"Epidemiology of different types of cancers reported in Basra, Iraq.","volume":"20","author":"R Abood","year":"2020","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e219","DOI":"10.5001\/omj.2021.18","article-title":"Cancer trends in Iraq 2000-2016.","volume":"36","author":"A Hussain","year":"2021","journal-title":"Oman Med. J."},{"key":"ref3","article-title":"Therapeutic Evaluation of Spironolactone and Finasteride in the Treatment of Acne Vulgaris.","volume":"6","author":"K Sharquie","year":"2007","journal-title":"Iraqi Postgraduate Medical Journal."},{"key":"ref4","article-title":"Study of Membrane Testosterone Receptors in Prostate Cancer.","volume":"4","author":"A AL-Timimi","year":"2007","journal-title":"Med. J. Babylon."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"4449-4461","DOI":"10.1080\/07391102.2020.1791957","article-title":"Computational investigation of potential inhibitors of novel coronavirus 2019 through structure-based virtual screening, molecular dynamics and density functional theory studies.","volume":"39","author":"S Mishra","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"123-130","DOI":"10.1021\/ci300514v","article-title":"Identification of novel androgen receptor antagonists using structure-and ligand-based methods.","volume":"53","author":"H Li","year":"2013","journal-title":"J. Chem. Inf. Model."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"26-37","DOI":"10.1016\/j.ymeth.2014.07.007","article-title":"Hierarchical virtual screening approaches in small molecule drug discovery.","volume":"71","author":"A Kumar","year":"2015","journal-title":"Methods."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"9496-9508","DOI":"10.1021\/jm400870h","article-title":"High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.","volume":"56","author":"V Sorna","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"4428","DOI":"10.3390\/molecules24244428","article-title":"Mimicking strategy for protein-protein interaction inhibitor discovery by virtual screening.","volume":"24","author":"K Wu","year":"2019","journal-title":"Molecules."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"30769-30780","DOI":"10.1074\/jbc.M112.379107","article-title":"Structure-based virtual screening and identification of a novel androgen receptor antagonist.","volume":"287","author":"C Song","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2197-2206","DOI":"10.1056\/NEJMoa2003892","article-title":"Enzalutamide and survival in nonmetastatic, castration-resistant prostate cancer.","volume":"382","author":"C Sternberg","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"486-494","DOI":"10.1007\/s10147-019-01554-3","article-title":"Enzalutamide versus flutamide for castration-resistant prostate cancer after combined androgen blockade therapy with bicalutamide: the OCUU-CRPC study.","volume":"25","author":"T Iguchi","year":"2020","journal-title":"Int. J. Clin. Oncol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"112156","DOI":"10.1016\/j.ejmech.2020.112156","article-title":"Novel androgen receptor antagonist identified by structure-based virtual screening, structural optimization, and biological evaluation.","volume":"192","author":"Q Tang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"416-427","DOI":"10.1016\/j.gpb.2018.03.007","article-title":"Discovery of novel androgen receptor ligands by structure-based virtual screening and bioassays.","volume":"16","author":"W Zhou","year":"2018","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"6197-6205","DOI":"10.1021\/jm200532b","article-title":"Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screening.","volume":"54","author":"P Axerio-Cilies","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.3390\/ijms19061784","article-title":"Endocrine disruption at the androgen receptor: Employing molecular dynamics and docking for improved virtual screening and toxicity prediction.","volume":"19","author":"J Wahl","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"229-239","DOI":"10.1038\/s41401-021-00632-5","article-title":"Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated docking-based virtual screening and bioassays.","volume":"43","author":"J Pang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"205-210","DOI":"10.1021\/acs.estlett.9b00073","article-title":"Molecular initiating events of bisphenols on androgen receptor-mediated pathways provide guidelines for in silico screening and design of substitute compounds.","volume":"6","author":"Q Chen","year":"2019","journal-title":"Environ. Sci. Technol. Lett."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"107490","DOI":"10.1016\/j.compbiolchem.2021.107490","article-title":"In silico and in vitro assessment of androgen receptor antagonists.","volume":"92","author":"O Ser\u00e7ino\u011flu","year":"2021","journal-title":"Comput. Biol. Chem."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.3390\/cells8111431","article-title":"Hits discovery on the androgen receptor: In silico approaches to identify agonist compounds.","volume":"8","author":"M R\u00e9au","year":"2019","journal-title":"Cells."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.5987597","article-title":"docking result of androgen [Data set]. In f (Version 1).","author":"H Al-Hussaniy","year":"2022","journal-title":"Zenodo."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-516\/v4\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-516\/v4\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-516\/v4\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T03:50:20Z","timestamp":1718941820000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-516\/v4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,11]]},"references-count":21,"URL":"https:\/\/doi.org\/10.12688\/f1000research.110072.4","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.110072.3","asserted-by":"subject"},{"id-type":"doi","id":"10.12688\/f1000research.110072.2","asserted-by":"subject"},{"id-type":"doi","id":"10.12688\/f1000research.110072.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.155650.r278968","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.155650.r268948","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.155650.r237280","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.155650.r268948","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.155650.r278968","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.155650.r237280","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,11]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-516\/v4#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.155650.r237280, Zarrin Basharat, Alpha Genomics Private Limited (Ringgold ID: 63596), Islamabad, 27 Jan 2024, version 4, indexed","URL":"https:\/\/f1000research.com\/articles\/11-516\/v4#referee-response-237280","order":0,"name":"referee-response-237280","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.155650.r268948, Ahmed A J Mahmood, Pharmacy college, University of Mosul, Mosul, Nineveh Governorate, 13 May 2024, version 4, indexed","URL":"https:\/\/f1000research.com\/articles\/11-516\/v4#referee-response-268948","order":1,"name":"referee-response-268948","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.155650.r278968, Mahmoud A. Al-Sha'er, Faculty of Pharmacy, Zarqa University, Zarqa, 24 May 2024, version 4, indexed","URL":"https:\/\/f1000research.com\/articles\/11-516\/v4#referee-response-278968","order":2,"name":"referee-response-278968","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>\u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0647\u0627\u0646\u064a \u0639\u0642\u064a\u0644<\/b>; \n<i>Posted: 29 May 2024<\/i>; Dear reviewer&nbsp; thank you for accepting the article this acceptance will help me a lot","URL":"https:\/\/f1000research.com\/articles\/11-516\/v4#referee-comment-11672","order":3,"name":"referee-comment-11672","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}