{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:43Z","timestamp":1772168863185,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.110660.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000}}],"reference-count":60,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Indonesian Directorate General Higher Education","award":["Grant number: 4\/AMD\/E1\/ KP.PTNBH\/2022"],"award-info":[{"award-number":["Grant number: 4\/AMD\/E1\/ KP.PTNBH\/2022"]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Malnutrition is the imbalance between intake and nutritional needs, resulting in a decrease in body weight, composition, and physical function. Malnutrition causes infertility due to intestinal\n                    <ns4:sup\/>\n                    and liver degeneration,which may progress to testicular and ovarian degeneration.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    An infertile female rat model with a degenerative ovary was induced with malnutrition through a 5-day food fasting but still had drinking water. The administration of (T1) 30% (v\/v) and (T2) 50% (v\/v) forest honey (\n                    <ns4:italic>Apis dorsata<\/ns4:italic>\n                    ) were performed for ten consecutive days, whereas the (T+) group was fasted and not administered forest honey and the (T\u2212) group has not fasted and not administered forest honey. Superoxide dismutase, malondialdehyde, IL-13 and TNF-\u03b1 cytokine expressions, and ovarian tissue regeneration were analyzed.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    Superoxide dismutase was significantly different (\n                    <ns4:italic>p<\/ns4:italic>\n                    &lt;0.05) in T1 (65.24\u00b17.53), T2 (74.16\u00b112.3), and T\u2212 (65.09\u00b16.56) compared with T+ (41.76\u00b18.51). Malondialdehyde was significantly different (\n                    <ns4:italic>p<\/ns4:italic>\n                    &lt;0.05) in T1 (9.71\u00b11.53), T2 (9.23\u00b10.96), and T\u2212 (9.83\u00b11.46) compared with T+ (15.28\u00b11.61). Anti-inflammatory cytokine (IL-13) expression was significantly different (\n                    <ns4:italic>p<\/ns4:italic>\n                    &lt;0.05) in T1 (5.30\u00b12.31), T2 (9.80\u00b12.53), and T\u2212 (0.30\u00b10.48) compared with T+ (2.70\u00b11.57). Pro-inflammatory cytokine (TNF-\u03b1) expression was significantly different (\n                    <ns4:italic>p<\/ns4:italic>\n                    &lt;0.05) in T1 (4.40\u00b13.02), T2 (2.50\u00b11.65), and T\u2212 (0.30\u00b10.48) compared with T+ (9.50\u00b11.78). Ovarian tissue regeneration was significantly different (\n                    <ns4:italic>p<\/ns4:italic>\n                    &lt;0.05) in T\u2212 (8.6\u00b10.69) and T2 (5.10\u00b10.99) compared with T1 (0.7\u00b10.95) and T+ (0.3\u00b10.67).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion:<\/ns4:bold>\n                    The 10-day administration of 50% (v\/v) forest honey can be an effective therapy for ovarian failure that caused malnutrition in the female rat model.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.110660.2","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T10:35:09Z","timestamp":1666262109000},"page":"512","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Effectiveness of forest honey (Apis dorsata) as therapy for ovarian failure causing malnutrition"],"prefix":"10.12688","volume":"11","author":[{"given":"Erma","family":"Safitri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hery","family":"Purnobasuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9496-0330","authenticated-orcid":false,"given":"Muhammad Thohawi Elziyad","family":"Purnama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shekhar","family":"Chhetri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"ref1","article-title":"Celebrating World Food Day with innovation to combat child malnutrition.","year":"2020"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e0204142","DOI":"10.1371\/journal.pone.0204142","article-title":"Double burden of malnutrition among children under 5 in poor areas of China.","volume":"13","author":"Y Zhang","year":"2018","journal-title":"PLoS One."},{"key":"ref3","article-title":"Children: Improving survival and well-being.","year":"2020"},{"key":"ref4","first-page":"37-45","article-title":"Changes in the Expression of CD4, IgA, PGE2, and Hsp70 Intestinal Mucosa Mus musculus Balb\/c Protein Energy Malnutrition Infected by Cryptosporidium. 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.139655.r153735, Ujjwal Layek, Department of Botany, Rampurhat College, Rampurhat, West Bengal, India, 21 Oct 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-512\/v2#referee-response-153735","order":0,"name":"referee-response-153735","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.122287.r143797, Aulanni\u2019am Aulanni'am, Husnul Khotimah, Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, Indonesia, 15 Sep 2022, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/11-512\/v1#referee-response-143797","order":1,"name":"referee-response-143797","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Muhammad Thohawi Elziyad Purnama<\/b>; <i>Posted: 09 Oct 2022<\/i>; Dear Reviewer,&nbsp; Thanks for your valuable comments and suggestions on the manuscript entitled: Effectiveness of forest honey (Apis dorsata) as therapy for ovarian failure causing malnutrition We welcome feedback. We have made modifications to the manuscript according the track comment.","URL":"https:\/\/f1000research.com\/articles\/11-512\/v2#referee-comment-8880","order":2,"name":"referee-comment-8880","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study was granted by The Indonesian Directorate General Higher Education (DIKTI) for funding this study (Grant number: 4\/AMD\/E1\/ KP.PTNBH\/2022).","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}