{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:07:29Z","timestamp":1792130849147,"version":"4.4.0"},"reference-count":18,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>In this review, we argue for the use of high-resolution computed tomography (HRCT) over chest X-ray in the initial evaluation of patients with sarcoidosis. Chest X-ray, which has long been used to classify disease severity and offer prognostication in sarcoidosis, has clear limitations compared with HRCT, including wider interobserver variability, a looser association with lung function, and poorer sensitivity to detect important lung manifestations of sarcoidosis. In addition, HRCT offers a diagnostic advantage, as it better depicts targets for biopsy, such as mediastinal\/hilar lymphadenopathy and focal parenchymal disease. Newer data suggest that specific HRCT findings may be associated with important prognostic outcomes, such as increased mortality. As we elaborate in this update, we strongly recommend the use of HRCT in the initial evaluation of the patient with sarcoidosis.<\/ns4:p>","DOI":"10.12688\/f1000research.11068.1","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T11:15:06Z","timestamp":1526469306000},"page":"600","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Is it time to scrap Scadding and adopt computed tomography for initial evaluation of sarcoidosis?"],"prefix":"10.12688","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-4739","authenticated-orcid":false,"given":"Andrew","family":"Levy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeel","family":"Hamzeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6872-1769","authenticated-orcid":false,"given":"Lisa A.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"1524-30","DOI":"10.1164\/rccm.201010-1679OC","article-title":"Sarcoidosis-related mortality in the United States from 1988 to 2007.","volume":"183","author":"J Swigris","year":"2011","journal-title":"Am J Respir Crit Care Med."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"53-74","DOI":"10.1055\/s-2007-970333","article-title":"Pulmonary sarcoidosis.","volume":"28","author":"J Lynch","year":"2007","journal-title":"Semin Respir Crit Care Med."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"66-73","DOI":"10.1016\/j.ejrad.2008.09.038","article-title":"The spectrum of pulmonary sarcoidosis: variations of high-resolution CT findings and clues for specific diagnosis.","volume":"73","author":"M Nishino","year":"2010","journal-title":"Eur J Radiol."},{"key":"ref-4","doi-asserted-by":"crossref","first-page":"1165-72","DOI":"10.1136\/bmj.2.5261.1165","article-title":"Prognosis of intrathoracic sarcoidosis in England. 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