{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:26:31Z","timestamp":1774308391886,"version":"3.50.1"},"reference-count":40,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background:<\/ns3:bold>\n                    The importance of esthetics has escalated over the years. The purpose of any perioplastic surgery is to address gingival recession while ensuring predictable root coverage and a pleasing appearance. An array of surgical procedures have been recommended for the management of recession defects. The present study compares the clinical and patient related outcome measures of coronally advanced flap with chorion membrane and connective tissue graft in the management of multiple adjacent gingival recessions.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Methods:<\/ns3:bold>\n                    The study was a prospective randomized controlled trial which included eight systemically healthy patients with an age range of 30-44 years with 36 labial\/buccal, multiple adjacent, Cairo\u2019s RT1 gingival recession defects, bilaterally. \u00a0CAF+CM was performed on one side whereas CAF+CTG was performed on the other side. The two groups were compared clinically at three and six months postoperatively.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Results:<\/ns3:bold>\n                    There was statistically significant decrease in recession depth, recession width, probing depth and clinical attachment level in both the groups from baseline to three and six months. However, intergroup comparisons revealed no statistically significant difference. At six months, both groups showed statistically significant improvements in keratinized tissue width and gingival thickness. The gingival thickness of the CAF+CM group increased significantly at three and six months. In terms of root coverage aesthetic score (RES), there was no significant difference observed between the two groups. In terms of patient reported outcome measures (PROMS), patients preferred the CAF+CM technique.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusion:<\/ns3:bold>\n                    Within the limits of the current study, the use of chorion membrane resulted in considerable root coverage and increased gingival thickness. Periodontal regeneration can be facilitated by the distinctive features of the chorion membrane. Coronally advanced flap plus chorion membrane is a novel approach for root coverage procedures.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.110829.1","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T05:20:06Z","timestamp":1652764806000},"page":"533","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Title-comparison of coronally advanced flap with chorion membrane vs coronally advanced flap with connective tissue graft in the treatment of multiple gingival recessions: a split-mouth randomised controlled study"],"prefix":"10.12688","volume":"11","author":[{"given":"Sweta","family":"Pradhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8841-6235","authenticated-orcid":false,"given":"Neetha","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8546-9590","authenticated-orcid":false,"given":"Deepa","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1-6","DOI":"10.1155\/2012\/837658","article-title":"Periodontal plastic surgery to improve aesthetics in patients with altered passive eruption\/gummy smile: A case series study.","volume":"2012","author":"F Cairo","year":"2012","journal-title":"Int. J. Dent."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"533-538","DOI":"10.4103\/0972-124X.106897","article-title":"An evaluation of a periodontal plastic surgical procedure for the reconstruction of interdental papillae in maxillary anterior region: A clinical study.","volume":"16","author":"M Sawai","year":"2012","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"671-701","DOI":"10.1902\/annals.1996.1.1.671","article-title":"Mucogingival Therapy.","volume":"1","author":"J Wennstr\u00f6m","year":"1996","journal-title":"Mucogingival Therapy."},{"key":"ref4","article-title":"Glossary of periodontal terms. 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Assoc."},{"key":"ref6","first-page":"215-220","article-title":"Gingival Recession: Short Literature Review on Etiology.","volume":"9","author":"S Ravipudi","year":"2017","journal-title":"Classifications and Various Treatment Options."},{"key":"ref7","first-page":"95-102","article-title":"The Subpedicle Connective Tissue Graft Coverage of Denuded A Bilaminar Reconstructive Procedure for the.","author":"S Nelson","year":"1986"},{"key":"ref8","first-page":"698-708","article-title":"Exploring the Gingival Recession Surgical Treatment Modalities: A Literature Review.","volume":"6","author":"M Shkreta","year":"2018"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"44-56","DOI":"10.1902\/jop.2004.75.1.44","article-title":"The clinical effect of acellular dermal matrix on gingival thickness and root coverage compared to coronally positioned flap alone.","volume":"75","author":"J Woodyard","year":"2004 Jan","journal-title":"J. Periodontol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"7-14","DOI":"10.1902\/jop.1996.67.1.7","article-title":"Comparative Study of a Bioresorbable and a Non-Resorbable Membrane in the Treatment of Human Buccal Gingival Recessions.","volume":"67","author":"M Roccuzzo","year":"1996","journal-title":"J. Periodontol."},{"key":"ref11","first-page":"473-483","article-title":"Role of platelet-rich plasma in soft tissue root-coverage procedures: a review.","volume":"39","author":"J Bashutski","year":"2008 Jun","journal-title":"Quintessence Int."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"659-671","DOI":"10.1016\/j.jdent.2008.05.007","article-title":"Can subepithelial connective tissue grafts be considered the gold standard procedure in the treatment of Miller Class I and II recession-type defects?.","volume":"36","author":"L Chambrone","year":"2008","journal-title":"J. Dent."},{"key":"ref13","article-title":"Periodontal Soft Tissue Root Coverage Procedures: A Systematic Review From the AAP Regeneration Workshop.","volume":"5","author":"L Chambrone","year":"2015"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1-9","DOI":"10.1155\/2015\/274082","article-title":"Amnion and Chorion Membranes: Potential Stem Cell Reservoir with Wide Applications in Periodontics.","volume":"2015","author":"A Gupta","year":"2015","journal-title":"Int. J. Biomater."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"12-16","DOI":"10.21767\/2471-3082.100043","article-title":"Amnion and Chorion Membranes for Root Coverage Procedures: An in vitro Evaluation of its Physical Characteristics.","volume":"04","author":"A George","year":"2018","journal-title":"Periodontics Prosthodont."},{"key":"ref16","article-title":"A Literature Review of the Safety and Biocompatibility of Amnion Tissue.","author":"E Chen","year":"2010","journal-title":"J. Implant. Adv. Clin. Dent."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"88-99","DOI":"10.22203\/eCM.v015a07","article-title":"Properties of the amniotic membrane for potential use in tissue engineering.","volume":"15","author":"H Niknejad","year":"2008 Apr","journal-title":"Eur. Cell. Mater."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"516-522","DOI":"10.1902\/jop.1986.57.8.516","article-title":"Extravascular Clot Formation and Platelet Activation on Variously Treated Root Surfaces.","volume":"57","author":"A Steinberg","year":"1986 Aug 1","journal-title":"J. Periodontol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"375-413","DOI":"10.1146\/annurev.bi.57.070188.002111","article-title":"Fibronectin And Its Receptors.","volume":"57","author":"E Ruoslahti","year":"1988","journal-title":"Annu. Rev. Biochem."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1-21","DOI":"10.1046\/j.1469-7580.1998.19310001.x","article-title":"The role of laminins in basement membrane function.","volume":"193","author":"M Aumailley","year":"1998","journal-title":"J. Anat."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"162-168","DOI":"10.15171\/joddd.2016.026","article-title":"Clinical comparison of coronally-advanced flap plus amniotic membrane or subepithelial connective tissue in the treatment of Miller\u2019s class I and II gingival recessions: A split-mouth study.","volume":"10","author":"A Lafzi","year":"2016","journal-title":"J. Dent. Res. Dent. Clin. Dent. Prospects."},{"key":"ref22","first-page":"661-6","article-title":"The interproximal clinical attachment level to classify gingival recessions and predict root coverage outcomes: an explorative and reliability study.","author":"F Cairo","year":"2011"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"610-616","DOI":"10.1902\/jop.1967.38.6.610","article-title":"The gingival index, the plaque index and the retention index systems.","volume":"38","author":"H L\u00f6e","year":"1967 Nov-Dec","journal-title":"J. Periodontol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"145-151","DOI":"10.1111\/j.1399-302X.1987.tb00298.x","article-title":"The microbiota associated with successful or failing osseointegrated titanium implants.","volume":"2","author":"A Mombelli","year":"1987","journal-title":"Oral Microbiol. Immunol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1506-1514","DOI":"10.1902\/jop.2000.71.9.1506","article-title":"Treatment of multiple recession-type defects in patients with esthetic demands.","volume":"71","author":"G Zucchelli","year":"2000 sep","journal-title":"J. Periodontol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"185-196","DOI":"10.1111\/j.1600-051X.1974.tb01257.x","article-title":"Clinical evaluation of free connective tissue grafts used to increase the width of keratinised gingiva.","volume":"1","author":"A Edel","year":"1974","journal-title":"J. Clin. Periodontol."},{"key":"ref27","first-page":"545-554","article-title":"Predictability of surgical techniques used for coverage of multiple adjacent gingival recessions-A systematic review.","volume":"43","author":"P Hofm\u00e4nner","year":"2012 Jul-Aug","journal-title":"Quintessence Int."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"S63-S76","DOI":"10.1111\/jcpe.12172","article-title":"Efficacy of periodontal plastic procedures in the treatment of multiple gingival recessions.","volume":"41","author":"F Graziani","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"135-146","DOI":"10.3109\/00207450108986541","article-title":"Evaluation of gingival recession in left- and right-handed adults.","volume":"110","author":"A Tezel","year":"2001","journal-title":"Int. J. Neurosci."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"295-306","DOI":"10.1902\/jop.2012.120143","article-title":"Is Surgical Root Coverage Effective for the Treatment of Cervical Dentin Hypersensitivity? A Systematic Review.","volume":"84","author":"D Douglas de Oliveira","year":"2013","journal-title":"J. Periodontol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"220-230","DOI":"10.1111\/jre.12199","article-title":"Root coverage by coronally advanced flap with connective tissue graft and\/or enamel matrix derivative: A meta-analysis.","volume":"50","author":"G Cheng","year":"2015","journal-title":"J. Periodontal Res."},{"key":"ref32","article-title":"Long-term Clinical Evaluation of Coronally Advanced Flap with Chorion Membrane for the Treatment of Multiple Adjacent Gingival Recession Defects.","author":"C Report","year":"2020"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"98-101","DOI":"10.7860\/JCDR\/2015\/12971.6572","article-title":"Amnion and chorion allografts in combination with coronally advanced flap in the treatment of gingival recession: A clinical study.","volume":"9","author":"S Chakraborthy","year":"2015","journal-title":"J. Clin. Diagnostic Res."},{"key":"ref34","first-page":"101-112","article-title":"Comparison of amnion allograft with connective tissue graft for root coverage procedures: a double-blind, randomized, controlled clinical trial.","volume":"15","author":"A Ghahroudi","year":"2013 Oct","journal-title":"J. Int. Acad. Periodontol."},{"key":"ref35","first-page":"127-135","article-title":"Evaluation of clinical, antiinflammatory and antiinfective properties of amniotic membrane used for guided tissue regeneration: A randomized controlled trial.","volume":"12","author":"A Kumar","year":"2015","journal-title":"Dent. Res. J."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2-10","DOI":"10.1902\/cap.2015.140059","article-title":"Periodontal Soft Tissue Root Coverage Procedures: Practical Applications From the AAP Regeneration Workshop. Clin Adv.","volume":"5","author":"C Richardson","year":"2015 Feb","journal-title":"Periodontics."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1403-1415","DOI":"10.1111\/jcpe.13346","article-title":"Aesthetic-And patient-related outcomes following root coverage procedures: A systematic review and network meta-analysis.","volume":"47","author":"F Cairo","year":"2020 Nov","journal-title":"J. Clin. 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