{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:30:53Z","timestamp":1770273053697,"version":"3.49.0"},"reference-count":93,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:00:00Z","timestamp":1499904000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EMBO Long Term Fellowship","award":["ALTF 140-2014"],"award-info":[{"award-number":["ALTF 140-2014"]}]},{"name":"European Commission\/Marie Curie Actions","award":["EMBOCOFUND2012, GA-2012-600394"],"award-info":[{"award-number":["EMBOCOFUND2012, GA-2012-600394"]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>The bacterial pathogen<ns4:italic> Listeria monocytogenes<\/ns4:italic> (<ns4:italic>Lm<\/ns4:italic>) is the causative agent of listeriosis, a rare but fatal foodborne disease. During infection, <ns4:italic>Lm<\/ns4:italic> can traverse several host barriers and enter the cytosol of a variety of cell types. Thus, consideration of the extracellular and intracellular niches of <ns4:italic>Lm<\/ns4:italic> is critical for understanding the infection process. Here, we review advances in our understanding of <ns4:italic>Lm<\/ns4:italic> infection and highlight how the interactions between the host and the pathogen are context dependent. We discuss discoveries of how <ns4:italic>Lm<\/ns4:italic> senses entry into the host cell cytosol. We present findings concerning how the nature of the various cytoskeleton components subverted by <ns4:italic>Lm<\/ns4:italic> changes depending on both the stage of infection and the subcellular context. We present discoveries of critical components required for <ns4:italic>Lm<\/ns4:italic> traversal of physiological barriers. Interactions between the host gut microbiota and <ns4:italic>Lm<\/ns4:italic> will be briefly discussed. Finally, the importance of <ns4:italic>Lm<\/ns4:italic> biodiversity and post-genomics approaches as a promising way to discover novel virulence factors will be highlighted.<\/ns4:p>","DOI":"10.12688\/f1000research.11363.1","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T12:00:10Z","timestamp":1499947210000},"page":"1126","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Recent advances in understanding Listeria monocytogenes infection: the importance of subcellular and physiological context"],"prefix":"10.12688","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9253-4805","authenticated-orcid":false,"given":"Daryl J. 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.12267.r23777, J\u00f6rgen Johansson, Department of Molecular Biology, Molecular Infection Medicine, Sweden (MIMS), and Ume\u00e5 Center for Microbial Research (UCMR), Ume\u00e5 University, Ume\u00e5, Sweden, 14 Jul 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-1126\/v1#referee-response-23777","order":0,"name":"referee-response-23777","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.12267.r23775, Anat A. Herskovits, Department of Molecular Microbiology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel, 14 Jul 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-1126\/v1#referee-response-23775","order":1,"name":"referee-response-23775","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.12267.r23776, Sarah D'Orazio, Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, 40536, USA, 14 Jul 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-1126\/v1#referee-response-23776","order":2,"name":"referee-response-23776","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Daryl J.V. David is supported by an EMBO Long Term Fellowship (ALTF 140-2014) and the European Commission\/Marie Curie Actions (EMBOCOFUND2012, GA-2012-600394). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}