{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T10:50:58Z","timestamp":1750157458666,"version":"3.37.3"},"reference-count":44,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U19 AI070235, R01 AI124355, R37 R37 A1045898"],"award-info":[{"award-number":["U19 AI070235, R01 AI124355, R37 R37 A1045898"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Eosinophilic esophagitis is a chronic, antigen-driven, eosinophil-predominant inflammatory disease of the esophagus and affects both children and adults. Cutting-edge technologies, such as genome-wide association studies, have advanced our understanding of the disease pathogenesis at a remarkable rate. Recent insights from genetic and mechanistic studies have concluded that a complex interplay between genetic and environmental risk factors, allergic sensitization, and esophageal-specific pathways leads to disease pathogenesis. Importantly, recent epidemiologic studies have found that the incidence and prevalence of eosinophilic esophagitis continue to rise. New guidelines have advocated the elimination of the term proton pump inhibitor (PPI)\u2013responsive esophageal eosinophilia and have recommended using PPIs as a first-line treatment modality. Systemic reviews and meta-analyses confirm the efficacy of PPIs, topical corticosteroids, and empiric food elimination diets. Unmet needs include the development of birth cohort studies, validated diagnostic scoring systems, minimally invasive disease-monitoring methods, and the development of new therapies.<\/ns4:p>","DOI":"10.12688\/f1000research.11798.1","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T06:30:07Z","timestamp":1506580207000},"page":"1775","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Recent advances in eosinophilic esophagitis"],"prefix":"10.12688","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8311-596X","authenticated-orcid":false,"given":"Sandy","family":"Durrani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Rothenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"591-601","DOI":"10.1586\/egh.12.42","article-title":"Eosinophilic gastroenteritis: an update.","volume":"6","author":"A Lucendo","year":"2012","journal-title":"Expert Rev Gastroenterol Hepatol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"335-58","DOI":"10.1177\/2050640616689525","article-title":"Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and 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Simon","year":"2016","journal-title":"Allergy."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/6-1775\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/6-1775\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/6-1775\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T12:56:22Z","timestamp":1553864182000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/6-1775\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,28]]},"references-count":44,"URL":"https:\/\/doi.org\/10.12688\/f1000research.11798.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.12750.r26160","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.12750.r26162","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.12750.r26161","asserted-by":"subject"}]},"ISSN":["2046-1402"],"issn-type":[{"type":"electronic","value":"2046-1402"}],"subject":[],"published":{"date-parts":[[2017,9,28]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/6-1775\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.12750.r26161, Michael F Vaezi, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, USA, 28 Sep 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-1775\/v1#referee-response-26161","order":0,"name":"referee-response-26161","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.12750.r26162, Edaire Cheng, Diana Montoya Melo, Pediatric Gastroenterology, Hepatology & Nutrition Division, University of Texas Southwestern Medical Center, Dallas, Texas, USA, 28 Sep 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-1775\/v1#referee-response-26162","order":1,"name":"referee-response-26162","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.12750.r26160, Yoshikazu Kinoshita, Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Shimane, Japan, 28 Sep 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-1775\/v1#referee-response-26160","order":2,"name":"referee-response-26160","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Marc Rothenberg<\/b>; \n<i>Posted: 01 Oct 2017<\/i>; This paper was published under Open Peer Review, which is a new format for publishing, where the paper is subjected to non-confidential review. Comments from the original reviewers and subsequent readers are open for dialog\/comment. I am pleased to spread information about eosinophilic disorders through this new format. I am also pleased to have partnered with a talented faculty member in my Division, Dr. Sandy Durrani, and welcome him to get more involved in the EoE and F1000 community.\u201d","URL":"https:\/\/f1000research.com\/articles\/6-1775\/v1#article-response-3074","order":3,"name":"article-response-3074","label":"Article Comment","group":{"name":"article-comments","label":"Article Comments"}},{"value":"This work was supported in part by National Institutes of Health U19 AI070235, National Institutes of Health R01 AI124355, and R37 R37 A1045898; the Campaign Urging Research for Eosinophilic Disease Foundation; the Buckeye Foundation; the American Partnership for Eosinophilic Disorders; and the Sunshine Charitable Foundation and its supporters, Denise A. Bunning and David G. Bunning. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}