{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:45:14Z","timestamp":1787755514292,"version":"build-2784847793"},"reference-count":18,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Background: Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique that is designed to remove substances with a large molecular weight. The TPE procedure includes removal of antibodies, alloantibodies, immune complexes, monoclonal protein, toxins or cytokines, and involves the replenishment of a specific plasma factor. The aim of the study was to describe the clinical response to TPE in various neurological patients, and to assess the clinical response to this therapy.<\/ns4:p>\n                  <ns4:p>Methods: The study was retrospective. We analyzed the medical records of 77 patients who were treated at the Department of Neurology, University Clinical Center (UCC) Tuzla from 2011 to 2016.\u00a0\u00a0<\/ns4:p>\n                  <ns4:p>Results: 83 therapeutic plasma exchanges were performed in the 77 patients. There was a slight predominance of male patients (54.5%), with an average age of 51\u00b115.9 years. The most common underlying neurological diseases were Guillain\u2013Barr\u00e9 syndrome (GBS) (37.7%), then chronic inflammatory demyelinating polyneuropathy (CIDP) (23.4%), multiple sclerosis\u00a0(MS) (11.7%) and myasthenia gravis (10.4%). Less frequent neurological diseases that were encountered were paraneoplastic polyneuropathies (5.2%), neuromyelitis optica (also known as Devic\u2019s disease) (3.9%), motor neuron disease (3.9%), polymyositis (2.6%) and multifocal motor neuropathy (1.2%).<\/ns4:p>\n                  <ns4:p>Conclusions: Six years experience of therapeutic plasma exchange in neurological patients in our department have shown that, following evidence-based guidelines for plasmapheresis, the procedure was most effective in patients with GBS, CIDP and myasthenia gravis.<\/ns4:p>","DOI":"10.12688\/f1000research.11841.1","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T09:15:17Z","timestamp":1501060517000},"page":"1234","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Plasmapheresis in neurological disorders: six years experience from University Clinical center Tuzla"],"prefix":"10.12688","volume":"6","author":[{"given":"Osman","family":"Sinanovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5684-3494","authenticated-orcid":false,"given":"Sanela","family":"Zuki\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Burina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermina","family":"Piri\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Hod\u017ei\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirza","family":"Ati\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna","family":"Ale\u010dkovi\u0107-Halilovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enisa","family":"Me\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"3-10","DOI":"10.1002\/jca.21257","article-title":"Therapeutic plasma exchange: a technical and operational review.","volume":"28","author":"A Kaplan","year":"2013","journal-title":"J Clin Apher."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"315-23","DOI":"10.1111\/j.1525-1594.1995.tb02334.x","article-title":"Apheresis technologies: an international perspective.","volume":"19","author":"P Malchesky","year":"1995","journal-title":"Artif Organs."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"1331-1339","DOI":"10.1586\/ern.09.81","article-title":"Plasmapheresis for neurological disorders.","volume":"9","author":"A Schr\u00f6der","year":"2009","journal-title":"Expert Rev Neurother."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"74-128","DOI":"10.1002\/(SICI)1098-1101(2000)15:1\/2<74::AID-JCA6>3.0.CO;2-O","article-title":"Therapeutic apheresis in neurological disorders.","volume":"15","author":"R Weinstein","year":"2000","journal-title":"J Clin Apher."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"189-194","DOI":"10.1002\/jca.2920080402","article-title":"An overview of current management.","volume":"8","author":"R Strauss","year":"1993","journal-title":"J Clin Apher."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"15-19","DOI":"10.4103\/0972-2327.144301","article-title":"Plasmapheresis in neurological disorders: Experience from a tertiary care hospital in South India.","volume":"18","author":"V Gafoor","year":"2015","journal-title":"Ann Indian Acad Neurol."},{"key":"ref-7","first-page":"237-245","article-title":"Plasmapheresis in neurologic disorders.","volume":"39","author":"P Kes","year":"2000","journal-title":"Acta Clin Croat."},{"key":"ref-8","first-page":"840-843","article-title":"Assessment of plasmapheresis. Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.","volume":"47","year":"1996","journal-title":"Neurology."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"e101","DOI":"10.1212\/WNL.0b013e318230b33f","article-title":"Evidence-based guideline update: plasmapheresis in neurologic disorders.","volume":"77","author":"B Khatri","year":"2011","journal-title":"Neurology."},{"key":"ref-10","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1212\/WNL.0b013e318230b33f","article-title":"Evidence-based guideline update: plasmapheresis in neurologic disorders.","volume":"77","author":"M McQuillen","year":"2011","journal-title":"Neurology."},{"key":"ref-11","first-page":"e101-2","article-title":"Evidence-based guideline update: plasmapheresis in neurologic disorders.","volume":"77","author":"H Kaminski","year":"2011","journal-title":"Neurology."},{"key":"ref-12","first-page":"e102-3","article-title":"Evidence-based guideline update: plasmapheresis in neurologic disorders.","volume":"77","author":"A Stork","year":"2011","journal-title":"Neurology."},{"key":"ref-13","first-page":"e103","article-title":"Evidence-based guideline update: plasmapheresis in neurologic disorders.","volume":"77","author":"F Mateen","year":"2011","journal-title":"Neurology."},{"key":"ref-14","first-page":"e104-5","article-title":"Evidence-based guideline update: plasmapheresis in neurologic disorders.","volume":"77","author":"M Winter","year":"2011","journal-title":"Neurology."},{"key":"ref-15","first-page":"e105","article-title":"Evidence-based guideline update: plasmapheresis in neurologic disorders.","volume":"77","author":"C Freeman","year":"2011","journal-title":"Neurology."},{"key":"ref-16","first-page":"120-131","article-title":"[Therapeutic plasma exchange: applications in neurology].","volume":"60","author":"J L\u00e1inez-Andr\u00e9s","year":"2015","journal-title":"Rev Neurol."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"1-11","DOI":"10.1097\/CND.0000000000000119","article-title":"Human Immunoglobulin Versus Plasmapheresis in Guillain-Barre Syndrome and Myasthenia Gravis: A Meta-Analysis.","volume":"18","author":"P Ortiz-Salas","year":"2016","journal-title":"J Clin Neuromuscul Dis."},{"key":"ref-18","doi-asserted-by":"publisher","DOI":"10.5256\/f1000research.11841.d169179","article-title":"Dataset 1 in: Plasmapheresis in neurological disorders: six years experience from University Clinical center Tuzla.","author":"O Sinanovi\u0107","year":"2017","journal-title":"F1000Research."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/6-1234\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/6-1234\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/6-1234\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T08:59:44Z","timestamp":1544086784000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/6-1234\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,26]]},"references-count":18,"URL":"https:\/\/doi.org\/10.12688\/f1000research.11841.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.12795.r25550","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.12795.r24544","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.12795.r25550","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.12795.r24544","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,26]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/6-1234\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.12795.r24544, David B. Vodusek, Division of Neurology, University Medical Center, Ljubljana, Ljubljana, Slovenia, 29 Aug 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-1234\/v1#referee-response-24544","order":0,"name":"referee-response-24544","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.12795.r25550, Hidenori Matsuo, Department of Clinical Research, Nagasaki Kawatana Medical Center, Nagasaki, Japan, 06 Sep 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-1234\/v1#referee-response-25550","order":1,"name":"referee-response-25550","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}