{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:06:20Z","timestamp":1772168780697,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.121402.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000}}],"reference-count":7,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006378","name":"Universitas Indonesia","doi-asserted-by":"publisher","award":["NKB-1302\/UN2.RST\/HKP.05.00\/2020"],"award-info":[{"award-number":["NKB-1302\/UN2.RST\/HKP.05.00\/2020"]}],"id":[{"id":"10.13039\/501100006378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:italic>Candida krusei<\/ns4:italic>\n                    is a\n                    <ns4:italic>Candida<\/ns4:italic>\n                    non-albicans species with a high prevalence, which causes candidaemia. Current treatment guidelines include fluconazole as a primary therapeutic option for the treatment of these infections; however, it is only a fungistatic against\n                    <ns4:italic>Candida spp<\/ns4:italic>\n                    ., and both inherent and acquired resistance to fluconazole have been reported.\n                    <ns4:italic>C<\/ns4:italic>\n                    .\n                    <ns4:italic>krusei<\/ns4:italic>\n                    species is also reported as the only\n                    <ns4:italic>Candida sp<\/ns4:italic>\n                    . which has an intrinsic resistance factor to fluconazole. Therefore, in dealing with antifungal resistance, it is necessary to develop new antifungal agents that are efficient in the treatment of fungal infections, especially those caused by\n                    <ns4:italic>C. krusei<\/ns4:italic>\n                    . The purpose of this study was to investigate the genome of clinical\n                    <ns4:italic>C. krusei<\/ns4:italic>\n                    isolates and correlate the resistant phenotypes with mutations in resistance genes. A total of 16 samples of\n                    <ns4:italic>C. krusei<\/ns4:italic>\n                    from clinical samples from hospitals in Jakarta were used in the experiment. All colonies were extracted using the QIAamp DNA Mini Kit. The library was prepared using the Illumina DNA Prep Kit. The sequencing process was carried out on the Illumina MiSeq Platform using a 2x301 paired-end configuration. FASTQ raw files are available under the BioProject Accession Number PRJNA819536 and Sequence Read Archive Accession Numbers SRR18739949 and SRR18739964.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.121402.2","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T09:00:16Z","timestamp":1680080416000},"page":"593","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole genome sequencing data of Candida krusei, the pathogen causing Candidaemia, from Department of Parasitology Culture Collection, Faculty of Medicine Universitas Indonesia"],"prefix":"10.12688","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8120-3138","authenticated-orcid":false,"given":"Fadilah","family":"Fadilah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4987-4839","authenticated-orcid":false,"given":"Robiatul","family":"Adawiyah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Retno","family":"Wahyuningsih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rozaliyani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayu Eka","family":"Fatril","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-4479","authenticated-orcid":false,"given":"Rafika Indah","family":"Paramita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Erlina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaerunissa Anbar","family":"Istiadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"602-611","DOI":"10.1111\/myc.12206","article-title":"Regional data analysis of Candida non- albicans strains collected in United States medical sites over a 6-year period, 2006-2011.","volume":"57","author":"M Pfaller","year":"Oct. 2014","journal-title":"Mycoses."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"354-369","DOI":"10.1128\/AAC.01095-08","article-title":"Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei.","volume":"53","author":"E Lamping","year":"Feb. 2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"575-578","DOI":"10.1080\/13693780600561544","article-title":"Fluconazole resistance mechanisms in Candida krusei: the contribution of efflux-pumps.","volume":"44","author":"J Guinea","year":"Sep. 2006","journal-title":"Med. Mycol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"151443","DOI":"10.1016\/j.ijmm.2020.151443","article-title":"Introduction of a bead beating step improves fungal DNA extraction from selected patient specimens.","volume":"310","author":"S Scharf","year":"Sep. 2020","journal-title":"Int. J. Med. Microbiol."},{"key":"ref6","article-title":"Illumina DNA Prep Reference Guide.","year":"2020"},{"key":"ref7","article-title":"MiSeq System Denature and DIlute Librariers Guide.","year":"2018"},{"key":"ref8","article-title":"q30 python script.","author":"S Chen","year":"2016"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-593\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-593\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-593\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:20:38Z","timestamp":1697692838000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-593\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,29]]},"references-count":7,"URL":"https:\/\/doi.org\/10.12688\/f1000research.121402.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.143748.r168114","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.143748.r168114","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,29]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-593\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.133265.r147383, Xuepeng Sun, Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang Province, College of Horticulture Science, Zhejiang A&F University, Hangzhou, 30 Aug 2022, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/11-593\/v1#referee-response-147383","order":0,"name":"referee-response-147383","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.143748.r168114, Atanu Banerjee, Amity Institute of Biotechnology,, Amity University Haryana, Manesar, Haryana, 04 Jul 2023, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-593\/v2#referee-response-168114","order":1,"name":"referee-response-168114","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study was supported by a PUTI Q1 2020 grant from Universitas Indonesia with grant number: NKB-1302\/UN2.RST\/HKP.05.00\/2020. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}