{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:06:55Z","timestamp":1772168815269,"version":"3.50.1"},"reference-count":12,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Purpose:<\/ns4:bold>\n                    To report a case of central retinal artery occlusion associated with sildenafil intake and briefly discuss its causative pathogenesis.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    A 50-year-old man with no premorbidities presented with symptoms of sudden severe visual field constriction in the left eye (LE). Best-corrected visual acuity in the LE was 20\/25. Fundus examination and fluorescein angiography of the LE were suggestive of central retinal artery occlusion (CRAO) with cilioretinal artery sparing. Further investigation revealed that 100 mg of sildenafil had been taken for the first time three hours before the onset of symptoms.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    The patient was treated promptly with intravenous acetazolamide, sublingual isosorbide dinitrate and ocular massage, but without visual recovery. No other associated systemic or local risk factors were found, and the case was classified as a potential complication of sildenafil.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion:<\/ns4:bold>\n                    Although no direct link could be established, the aim of this report is to highlight the incidence and to consider this issue when evaluating any case of central retinal artery occlusion.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.122087.1","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T08:05:15Z","timestamp":1654070715000},"page":"600","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Central retinal artery occlusion following sildenafil intake"],"prefix":"10.12688","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-3081","authenticated-orcid":false,"given":"Anis","family":"Mahmoud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Abid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molka","family":"Khairallah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Sakji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-5738","authenticated-orcid":false,"given":"Hassen","family":"Ibn Hadj Amor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala","family":"Attia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh","family":"Mbarek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riadh","family":"Messaoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2894-2903","DOI":"10.1111\/j.1743-6109.2011.02382.x","article-title":"Are phosphodiesterase type 5 inhibitors associated with vision-threatening adverse events? A critical analysis and review of the literature.","volume":"8","author":"F Azzouni","year":"2011","journal-title":"J. Sex. Med."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"934-935","DOI":"10.1136\/bjo.84.8.928g","article-title":"Branch retinal artery occlusion; another complication of sildenafil.","volume":"84","author":"A Tripathi","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.oret.2017.08.024","article-title":"High-Dose Sildenafil-associated Acute Macular Neuroretinopathy Variant.","volume":"2","author":"A Kolomeyer","year":"2018","journal-title":"Ophthalmol. Retina."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"537-543","DOI":"10.1038\/ijir.2008.25","article-title":"Nonarteritic anterior ischemic optic neuropathy with PDE-5 inhibitors for erectile dysfunction.","volume":"20","author":"M Thurtell","year":"2008","journal-title":"Int. J. Impot. 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Ther."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1-4","DOI":"10.1155\/2021\/2006271","article-title":"Central Retinal Artery Occlusion Associated with Sildenafil Overdose.","volume":"2021","author":"M Abrishami","year":"2021","journal-title":"Case Rep. Ophthalmol. Med."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1471-1473","DOI":"10.1001\/jamaophthalmol.2013.5047","article-title":"Acute, bilateral, concurrent central retinal artery occlusion in sickle cell disease after use of tadalafil (Cialis).","volume":"131","author":"R Murthy","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40942-020-00241-0","article-title":"Effects of phosphodiesterase type 5 inhibitors on choroid and ocular vasculature: a literature review.","volume":"6","author":"N Cruz","year":"2020","journal-title":"Int. J. Retina Vitreous."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"65-70","DOI":"10.1038\/s41443-018-0099-2","article-title":"Sildenafil\/Viagra in the treatment of premature ejaculation.","volume":"31","author":"P Krishnappa","year":"2019","journal-title":"Int. J. Impot. Res."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"65-70","DOI":"10.1038\/s41443-018-0099-2","article-title":"Sildenafil\/Viagra in the treatment of premature ejaculation.","volume":"31","author":"P Krishnappa","year":"2019","journal-title":"Int. J. Impot. Res."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-600\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-600\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-600\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T05:55:24Z","timestamp":1663653324000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-600\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":12,"URL":"https:\/\/doi.org\/10.12688\/f1000research.122087.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.134029.r150351","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.134029.r139570","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.134029.r139570","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.134029.r150351","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-600\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.134029.r139570, Yousra Falfoul, Oculogenetic Laboratory LR14SP01, Faculty of Medicine of Tunis, Hedi Rais Institute of Ophthalmology (Department B), Tunis El Manar University, Tunis, Tunisia, 21 Jun 2022, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/11-600\/v1#referee-response-139570","order":0,"name":"referee-response-139570","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.134029.r150351, Wassim Ben Hadj Salah, Service d\u2019Ophtalmologie, Centre Hospitalier Louis Pasteur, Le Coudray, France, 20 Sep 2022, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/11-600\/v1#referee-response-150351","order":1,"name":"referee-response-150351","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}