{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:00:00Z","timestamp":1773280800807,"version":"3.50.1"},"reference-count":49,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Although mechanical ventilation is a life-saving strategy in critically ill patients and an indispensable tool in patients under general anesthesia for surgery, it also acts as a double-edged sword. Indeed, ventilation is increasingly recognized as a potentially dangerous intrusion that has the potential to harm lungs, in a condition known as \u2018ventilator-induced lung injury\u2019 (VILI). So-called \u2018lung-protective\u2019 ventilator settings aiming at prevention of VILI have been shown to improve outcomes in patients with acute respiratory distress syndrome (ARDS), and, over the last few years, there has been increasing interest in possible benefit of lung-protective ventilation in patients under ventilation for reasons other than ARDS. Patients without ARDS could benefit from tidal volume reduction during mechanical ventilation. However, it is uncertain whether higher levels of positive end-expiratory pressure could benefit these patients as well. Finally, recent evidence suggests that patients without ARDS should receive low driving pressures during ventilation.<\/ns4:p>","DOI":"10.12688\/f1000research.12225.1","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T05:55:06Z","timestamp":1511330106000},"page":"2040","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Patients with uninjured lungs may also benefit from lung-protective ventilator settings"],"prefix":"10.12688","volume":"6","author":[{"given":"Roger","family":"Alencar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"D'Angelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Carmona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus J","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1520-9387","authenticated-orcid":false,"given":"Ary","family":"Serpa Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"2126-36","DOI":"10.1056\/NEJMra1208707","article-title":"Ventilator-induced lung injury.","volume":"369","author":"A Slutsky","year":"2013","journal-title":"N Engl J Med."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"w14211","DOI":"10.4414\/smw.2015.14211","article-title":"Current concepts of protective ventilation during general anaesthesia.","volume":"145","author":"A Serpa Neto","year":"2015","journal-title":"Swiss Med Wkly."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"692-713","DOI":"10.1097\/ALN.0000000000000754","article-title":"Intraoperative protective mechanical ventilation for prevention of postoperative pulmonary complications: a comprehensive review of the role of tidal volume, positive end-expiratory pressure, and lung recruitment maneuvers.","volume":"123","author":"A G\u00fcldner","year":"2015","journal-title":"Anesthesiology."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"1301-8","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.","volume":"342","author":"R Brower","year":"2000","journal-title":"N Engl J Med."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"788-800","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.","volume":"315","author":"G Bellani","year":"2016","journal-title":"JAMA."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"1253-63","DOI":"10.1164\/rccm.201703-0548ST","article-title":"An Official American Thoracic Society\/European Society of Intensive Care Medicine\/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome.","volume":"195","author":"E Fan","year":"2017","journal-title":"Am J Respir Crit Care Med."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"566-76","DOI":"10.7326\/0003-4819-151-8-200910200-00011","article-title":"Meta-analysis: ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury.","volume":"151","author":"C Putensen","year":"2009","journal-title":"Ann Intern Med."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"347-54","DOI":"10.1056\/NEJM199802053380602","article-title":"Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.","volume":"338","author":"M Amato","year":"1998","journal-title":"N Engl J Med."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"826-35","DOI":"10.1097\/ALN.0b013e3181b764d2","article-title":"Tidal volume lower than 6 ml\/kg enhances lung protection: role of extracorporeal carbon dioxide removal.","volume":"111","author":"P Terragni","year":"2009","journal-title":"Anesthesiology."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"847-56","DOI":"10.1007\/s00134-012-2787-6","article-title":"Lower tidal volume strategy (\u22483 ml\/kg) combined with extracorporeal CO2 removal versus 'conventional' protective ventilation (6 ml\/kg) in severe ARDS: the prospective randomized Xtravent-study.","volume":"39","author":"T Bein","year":"2013","journal-title":"Intensive Care Med."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"1159-64","DOI":"10.1164\/ajrccm\/137.5.1159","article-title":"High inflation pressure pulmonary edema. 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