{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:06:55Z","timestamp":1772168815614,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.122298.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000}}],"reference-count":14,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"\n Background:<\/ns3:bold>\n Takotsubo syndrome (TS) is characterized by a clinical presentation that mimics acute coronary syndrome but is reversible. Alterations of Takotsubo in patients without previous heart disease remain a challenge for diagnosis.\n <\/ns3:p>\n \n Case report:<\/ns3:bold>\n We present a case of an 80-year-old patient from Peru. The patient underwent surgery, with the diagnosis of Chilaiditi\u2019s syndrome. One day after surgery, she presented with dyspnea, tachycardia, and electrocardiographic changes (paroxysmal atrial fibrillation and infrequent ventricular extrasystoles without abnormalities in the ST-segment). The diagnosis of Takotsubo syndrome with cardiogenic shock was made. She was hospitalized in the Intensive Care Unit and was managed with vasopressors and nitroglycerin. There was no cardiac lesion in the cineangiogram or occlusion of arteries. The patient was extubated and received daily dialysis until discharge.\n <\/ns3:p>\n \n Conclusions<\/ns3:bold>\n :\u00a0Takotsubo is an emotional, non-cardiac, or post-traumatic stressful event that triggers myocardial injury with segmental anomalous, the possible etiology of which is the release of an endothelial neurotransmitter caused by stress. Emergency physicians should be aware of this as even patients without previous cardiac pathologies when exposed to stressors (such as surgeries) develop emergency symptomatology similar to myocardial infarction. Thus, emergency physicians should identify any cardiac abnormalities after a stressor, as well as be prepared for the diagnosis of TS.\n <\/ns3:p>","DOI":"10.12688\/f1000research.122298.2","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T09:50:41Z","timestamp":1668419441000},"page":"616","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Takotsubo syndrome in a postoperative patient without cardiological disease"],"prefix":"10.12688","volume":"11","author":[{"given":"Luis","family":"Coaguila-Cusicanqui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Castillo-Atoche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Montalvo-Suyon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriko","family":"Cavero-Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-9342","authenticated-orcid":false,"given":"Virgilio E.","family":"Failoc-Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"809-816","DOI":"10.1378\/chest.07-0608","article-title":"Apical and midventricular transient left ventricular dysfunction syndrome (tako-tsubo cardiomyopathy): frequency, mechanisms, and prognosis.","volume":"132","author":"V Kurowski","year":"2007","journal-title":"Chest."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"53-65","DOI":"10.1007\/s10286-017-0465-z","article-title":"Epidemiology, pathogenesis, and management of takotsubo syndrome.","volume":"28","author":"S Hassan","year":"2018","journal-title":"Clin. Auton. Res."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1461-1469","DOI":"10.1136\/heartjnl-2016-309783","article-title":"Takotsubo syndrome: aetiology, presentation and treatment.","volume":"103","author":"K Kato","year":"2017","journal-title":"Heart."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"339-346","DOI":"10.1007\/s00059-006-2822-x","article-title":"Tako-tsubo cardiomyopathy. Incidence in patients with acute coronary syndrome.","volume":"31","author":"H Wedekind","year":"2006","journal-title":"Herz."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"929-938","DOI":"10.1056\/NEJMoa1406761","article-title":"Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.","volume":"373","author":"C Templin","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"333-341","DOI":"10.1016\/j.jacc.2009.08.057","article-title":"Natural history and expansive clinical profile of stress (tako-tsubo) cardiomyopathy.","volume":"55","author":"S Sharkey","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1320-1325","DOI":"10.1016\/j.jacc.2009.02.020","article-title":"Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists.","volume":"53","author":"J Abraham","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4150291","DOI":"10.1155\/2020\/4150291","article-title":"The Brain-Heart Connection in Takotsubo Syndrome: The Central Nervous System, Sympathetic Nervous System, and Catecholamine Overload.","volume":"2020","author":"X Wang","year":"2020","journal-title":"Cardiol. Res. Pract."},{"key":"ref9","first-page":"1010243","article-title":"Takotsubo Syndrome Associated with ST Elevation Myocardial Infarction.","volume":"2019","author":"S Ezad","year":"2019","journal-title":"Case Rep. Cardiol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"83-88","DOI":"10.15420\/ecr.2015.10.2.83","article-title":"Takotsubo Syndrome - Stress-induced Heart Failure Syndrome.","volume":"10","author":"M Sheppard","year":"2015","journal-title":"Eur. Cardiol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"8-27","DOI":"10.1002\/ejhf.424","article-title":"Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology.","volume":"18","author":"A Lyon","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"522-526","DOI":"10.1016\/j.carrev.2019.07.022","article-title":"Clinical impact of atrial fibrillation on short-term outcomes and in-hospital mortality in patients with Takotsubo Syndrome: A propensity-matched national study.","volume":"21","author":"A Yassin","year":"2019","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"255-259","DOI":"10.17843\/rpmesp.2019.362.4622","article-title":"Clinical features and complications of Takotsubo syndrome in a peruvian social security referral center.","volume":"36","author":"D Espinoza-Alva","year":"2019","journal-title":"Rev. Peru. Med. Exp. Salud Publica."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"215-221","DOI":"10.1016\/j.ahj.2012.04.010","article-title":"In-hospital mortality among patients with takotsubo cardiomyopathy: a study of the National Inpatient Sample 2008 to 2009.","volume":"164","author":"W Brinjikji","year":"2012","journal-title":"Am. Heart J."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-616\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-616\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-616\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T08:12:33Z","timestamp":1728547953000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-616\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,14]]},"references-count":14,"URL":"https:\/\/doi.org\/10.12688\/f1000research.122298.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.122298.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.140629.r155720","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.140629.r326998","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.140629.r326998","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.140629.r155720","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,14]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-616\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.134270.r141232, Carlos Culquichicon, Fred Hutch, Seattle, WA, 05 Jul 2022, version 1, 1 approved, 1 approved with reservations, 1 not approved","URL":"https:\/\/f1000research.com\/articles\/11-616\/v1#referee-response-141232","order":0,"name":"referee-response-141232","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Virgilio E Failoc-Rojas<\/b>; \nPosted: 01 Nov 2022<\/i>; \nResponse to Reviewer 1<\/b> - Provide summarized details about the "electrocardiographic changes" in the abstract section. \nResponse: Thank you. We have added the suggested information.<\/i><\/b> - "The diagnosis of Takotsubo syndrome with cardiogenic shock and renal failure on hemodialysis was made". It is unclear whether the Takotsubo diagnosis was made during or before hemodialysis. \nResponse: Thank you. We have revised the sentence for clarity.<\/i><\/b> - In the 3rd paragraph of the discussion section, the authors mention that some other cardiomyopathies were ruled out. It might be good to know which diseases were ruled out and the rationale. \nResponse: Thank you. We have added the requested diseases and the rationale.<\/i><\/b> - It would be great if an English-native clinical expert checks the accuracy of medical terminology. \nResponse: Thank you. The medical terminology was revised as suggested.<\/i><\/b>","URL":"https:\/\/f1000research.com\/articles\/11-616\/v2#referee-comment-8973","order":1,"name":"referee-comment-8973","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.140629.r155720, John D. Horowitz, Freemasons Centre for Male Health and Wellbeing, South Australian Health and Medical Research Institute, School of Medicine, The University of Adelaide, Adelaide, SA, 16 Nov 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-616\/v2#referee-response-155720","order":2,"name":"referee-response-155720","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.134270.r144262, Takeshi Nishimura, Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center, Kobe, 25 Jul 2022, version 1, 1 approved, 1 approved with reservations, 1 not approved","URL":"https:\/\/f1000research.com\/articles\/11-616\/v1#referee-response-144262","order":3,"name":"referee-response-144262","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Virgilio E Failoc-Rojas<\/b>; \nPosted: 01 Nov 2022<\/i>; \nResponse to Reviewer 3<\/b> Describe the findings of the laparotomy. Chilaiditi's syndrome does not require a surgical treatment. \nResponse: Thank you. We have described the findings of laparotomy. Indeed, Chilaiditi's syndrome generally has conservative management. However, the main diagnosis was closed abdominal trauma, which did require immediate surgery.<\/i><\/b> Add the information of cardiac enzyme (CK-MB). \nResponse: Thank you. We have added the information of cardiac enzyme.<\/i><\/b> Nitroglycerine is not appropriate to treat TC. Show the reason why authors applied this treatment. \nResponse: Thank you.  We have provided the reason why nitroglycerine was used.<\/i><\/b> Discussion: each paragraph should include the topics authors would like to emphasize. The mixing of short and long paragraphs makes following the right discussion points difficult. \nResponse: Thank you for your feedback. This section was revised accordingly.<\/i><\/b> Authors just addressed the knowledge which is already known in previous reports. Readers would like to know academic aspects from this case. To improve the quality of this case report, this reviewer recommends authors to reconsider the concept of this case. \nResponse: Thank you. We have provided more information on academic aspects from the case. The message of this case was reevaluated, and it was reinforced in the conclusion.<\/i><\/b> Also, I recommend the manuscript be proofread. \nResponse: Thank you. The manuscript was proofread as suggested.<\/i><\/b>","URL":"https:\/\/f1000research.com\/articles\/11-616\/v2#referee-comment-8975","order":4,"name":"referee-comment-8975","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.140629.r326998, Hawani Sasmaya Prameswari, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Padjadjaran University, Bandung, 10 Oct 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-616\/v2#referee-response-326998","order":5,"name":"referee-response-326998","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":6,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}