{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:51:32Z","timestamp":1793055092984,"version":"4.5.0"},"reference-count":19,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Healthium Medtech Limited"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background:<\/ns3:bold>\n                    Mesioangular impacted mandibular third molar is a common dental anomaly, for which surgical extraction is required. Post-surgery closure of mucosa reduces the prevalence of pain and other surgery-associated complications. We compared tissue reaction\/inflammation after 3 and 7 days of mucosal closure with Trusilk\n                    <ns3:sup>\u00ae<\/ns3:sup>\n                    and Mersilk\n                    <ns3:sup>\u00ae<\/ns3:sup>\n                    silk sutures, following impacted mandibular third molar removal.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Methods:<\/ns3:bold>\n                    This multicenter, prospective, two-arm, parallel-group, randomized (1:1), single-blind study (July 2020-November 2021) included subjects (Trusilk\n                    <ns3:sup>\u00ae<\/ns3:sup>\n                    , n=65 and Mersilk\n                    <ns3:sup>\u00ae<\/ns3:sup>\n                    , n=64), requiring mucosal suturing following impacted mandibular third molar removal. The primary endpoint, incidence of pain, swelling and trismus at the extraction area on post-surgery day 3 and 7 was evaluated. The secondary endpoints, incidence of tissue reaction, wound infection, suture loosening, other complications, operative time, amount of anesthesia, intraoperative suture handling, time needed for complete wound healing and suture removal, and adverse events were also recorded.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Results:<\/ns3:bold>\n                    Socio-demographic and intra-oral characteristics were comparable between the groups.\n                    <ns3:sup\/>\n                    In Trusilk\n                    <ns3:sup>\u00ae<\/ns3:sup>\n                    and Mersilk\n                    <ns3:sup>\u00ae<\/ns3:sup>\n                    groups, a gradually decreasing pain score, starting from day 0 post-surgery (42.17\u00b122.38 vs. 45.97\u00b122.20) to day 7 (8.40\u00b111.93 vs. 8.28\u00b112.13) to day 30 (1.98\u00b10.89 vs. 1.75\u00b10.76) was witnessed. After the surgery, 21.54% and 17.19% subjects in Trusilk\n                    <ns3:sup>\u00ae<\/ns3:sup>\n                    and Mersilk\n                    <ns3:sup>\u00ae<\/ns3:sup>\n                    groups, respectively, had no post-operative swelling, while at the last two visits none of the subjects had swelling. Non-significant difference in wound infection, suture loosening, wound healing, bleeding, taste changes, operative time, amount of anesthesia, intraoperative suture handling, and time needed for complete wound healing and suture removal was noted among the groups. No suture-related adverse events were recorded.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusions:<\/ns3:bold>\n                    The results indicated that the Trusilk\n                    <ns3:sup>\u00ae<\/ns3:sup>\n                    and Mersilk\n                    <ns3:sup>\u00ae<\/ns3:sup>\n                    silk sutures are clinically equivalent and can be used for mucosal closure after removal of an impacted mandibular third molar with a minimal rate of pain, swelling and trismus.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Clinical Trial Registry of India Registration:<\/ns3:bold>\n                    CTRI\/2020\/03\/024100 (20\/03\/2020)\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.122678.1","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T12:45:24Z","timestamp":1655815524000},"page":"689","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Single blind, randomized study comparing clinical equivalence of Trusilk\u00ae and Mersilk\u00ae silk sutures for mucosal closure following surgical removal of mesioangular impacted mandibular third molar"],"prefix":"10.12688","volume":"11","author":[{"given":"Ramdas","family":"Balakrishna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-2077","authenticated-orcid":false,"given":"Dharnappa","family":"Poojary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"R","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikanth","family":"Sali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Moharana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"TS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"ref1","first-page":"548-552","article-title":"Retrospective demographic study on tooth impaction in a Malaysian sample.","volume":"12","author":"M Kashmoola","year":"2019","journal-title":"J. Int. Dent. Med. Res."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e140-e145","DOI":"10.4317\/medoral.18028","article-title":"Incidence of impacted mandibular and maxillary third molars: A radiographic study in a southeast iran population.","volume":"18","author":"M Hashemipour","year":"2013","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"76-81","DOI":"10.1016\/j.jobcr.2014.04.001","article-title":"Incidence of impacted third molars: A radiographic study in People\u2019s Hospital, Bhopal, India.","volume":"4","author":"A Pillai","year":"2014","journal-title":"J. Oral Biol. Craniofacial Res."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"262-268","DOI":"10.1016\/j.sdentj.2020.01.002","article-title":"Prevalence of impacted third molars and the reason for extraction in Saudi Arabia.","volume":"32","author":"L Alfadil","year":"2020","journal-title":"Saudi Dent. J."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1-10","DOI":"10.3390\/dj7030088","article-title":"An insight into acute pericoronitis and the n1. Wehr C, Cruz G, Young S, Fakhouri WD. An insight into acute pericoronitis and the need for an evidence-based standard of care. D.","volume":"7","author":"C Wehr","year":"2019","journal-title":"Dent. J."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e278-e286","DOI":"10.4317\/jced.56887","article-title":"Indications of the Extraction of Symptomatic Impacted Third Molars. A Systematic Review.","volume":"13","author":"M Pe\u00f1arrocha-Diago","year":"2021","journal-title":"J. Clin. Exp. Dent."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"23-43","DOI":"10.1016\/j.coms.2006.11.012","article-title":"General Technique of Third Molar Removal.","volume":"19","author":"S Farish","year":"2007","journal-title":"Oral Maxillofac. Surg. Clin. North Am."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"229-234","DOI":"10.4103\/2141-9248.160177","article-title":"Impacted mandibular third molars: Review of literature and a proposal of a combined clinical and radiological classification.","volume":"5","author":"P Santosh","year":"2015","journal-title":"Ann. Med. Health Sci. Res."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"37-43","DOI":"10.1007\/s10006-019-00814-w","article-title":"Comparison of primary and secondary closure with a buccal mucosal-advancement flap on postoperative course after mandibular impacted third molar surgery.","volume":"24","author":"R Balamurugan","year":"2020","journal-title":"Oral Maxillofac. Surg."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"278-287","DOI":"10.1016\/j.identj.2022.02.005","article-title":"Characteristics of Suture Materials Used in Oral Surgery: Systematic Review.","volume":"72","author":"A Faris","year":"2022","journal-title":"Int. Dent. J."},{"key":"ref11","first-page":"105-118","article-title":"Effectiveness of benzydamyne HCl in the treatment of periodontal post-surgical patients.","volume":"10","author":"R Landry","year":"1988","journal-title":"Res. Clin. Forums."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"10-14","DOI":"10.4103\/0975-5950.102141","article-title":"Primary and secondary closure technique following removal of impacted mandibular third molars: A comparative study.","volume":"3","author":"M Chaudhary","year":"2012","journal-title":"Natl. J. Maxillofac. Surg."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1-17","DOI":"10.3390\/ph14050456","article-title":"Periodontal wound healing and tissue regeneration: A narrative review.","volume":"14","author":"Y Cho","year":"2021","journal-title":"Pharmaceuticals."},{"key":"ref14","first-page":"530-537","article-title":"Management of inflammatory complications in third molar surgery: A review of the literature.","volume":"11","author":"O Osunde","year":"2011","journal-title":"Afr. Health Sci."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"82-90","DOI":"10.1563\/1548-1336-35.2.82","article-title":"Suturing for optimal soft-tissue management.","volume":"35","author":"L Silverstein","year":"2009","journal-title":"J. Oral Implantol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"257-263","DOI":"10.2147\/PPA.S76236","article-title":"Patients\u2019 satisfaction and prevalence of complications on surgical extraction of third molar.","volume":"9","author":"C Lee","year":"2015","journal-title":"Patient Prefer. Adherence."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e95-e102","DOI":"10.4317\/medoral.20721","article-title":"Antibacterial suture vs silk for the surgical removal of impacted lower third molars. A randomized clinical study.","volume":"21","author":"S Sala-P\u00e9rez","year":"2016","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.20059679.v1","article-title":"Trusilk Study Complete PP Data. figshare. [Dataset].","author":"R Balakrishna","year":"2022"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.20055599.v2","article-title":"CONSORT check list. figshare.","author":"R Balakrishna","year":"2022 cited 2022 Jun 11"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-689\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-689\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-689\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T06:15:14Z","timestamp":1662963314000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-689\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":19,"URL":"https:\/\/doi.org\/10.12688\/f1000research.122678.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.134700.r145906","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.134700.r143057","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.134700.r145906","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.134700.r143057","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-689\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.134700.r143057, Abhay\u00a0Taranath Kamath, Department\u00a0of\u00a0Oral\u00a0&\u00a0Maxillofacial\u00a0Surgery, KMC\u00a0Hospital, Mangalore, India, 25 Jul 2022, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/11-689\/v1#referee-response-143057","order":0,"name":"referee-response-143057","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.134700.r145906, Jingade Krishnojirao Dayashankara Rao, Department of Maxillo Facial Surgery & Diagnostic Science, College of Dentistry, Qassim University, Buraida, Saudi Arabia, 12 Sep 2022, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/11-689\/v1#referee-response-145906","order":1,"name":"referee-response-145906","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study was supported by Healthium Medtech Limited, Bangalore.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}