{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:10Z","timestamp":1772168830143,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.122693.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000}},{"DOI":"10.12688\/f1000research.122693.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000}}],"reference-count":9,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lasers in Dentistry Research Group, Khon Kaen University"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background<\/ns4:bold>\n                    : A pyogenic granuloma (PG) is a common benign vascular lesion found in the oral cavity. The gold standard treatment of this lesion, comprising surgical excision and the elimination of etiological factors, cannot avoid tooth loss in the case of an aggressive pyogenic granuloma. Because of the prominent properties of 980 nm and 635 nm diode lasers in photocoagulation and photobiomodulation, we applied these wavelengths in the treatment of a large pyogenic granuloma with alveolar bone loss.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Case presentation<\/ns4:bold>\n                    : Our objective was to use a combination of interstitial-intralesional laser therapy, photocoagulation and laser-assisted new attachment procedure (LANAP) to preserve the teeth and periodontal tissue in a case of an aggressive pyogenic granuloma.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results<\/ns4:bold>\n                    : The patient was a 13-year-old Thai male with a pyogenic granuloma involving the interdental papilla and lingual gingiva of the lower left first and second molars. The teeth were also displaced by the lesion. After treatment with three sessions of photocoagulation, three sessions of interstitial-intralesional laser therapy and two sessions of LANAP, the lesion was completely resolved. The periodontal status of the teeth was improved at the six-month follow-up.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion<\/ns4:bold>\n                    : The combination of interstitial-intralesional laser therapy, photocoagulation and LANAP was able to treat an aggressive pyogenic granuloma with tooth preservation.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.122693.3","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T10:25:07Z","timestamp":1665138307000},"page":"883","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Interstitial-intralesional laser therapy and laser-assisted new attachment procedure for the treatment of alveolar bone loss provoked by an aggressive pyogenic granuloma"],"prefix":"10.12688","volume":"11","author":[{"given":"Anon","family":"Akkarapatum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poramaporn","family":"Klanrit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7111-9381","authenticated-orcid":false,"given":"Sajee","family":"Sattayut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"167-175","DOI":"10.2334\/josnusd.48.167","article-title":"Oral pyogenic granuloma: a review.","volume":"48","author":"H Jafarzadeh","year":"2006","journal-title":"J. Oral Sci."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"155-165","DOI":"10.1002\/lsm.20134","article-title":"Mechanistic comparison of blood undergoing laser photocoagulation at 532 and 1,064 nm.","volume":"36","author":"J Black","year":"2005","journal-title":"Lasers Surg. Med."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"228-232","DOI":"10.15171\/jlms.2018.41","article-title":"Laser treatment of oral and maxillofacial hemangioma.","volume":"9","author":"E Azma","year":"2018","journal-title":"J. Lasers Med. Sci."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1575-1582","DOI":"10.1080\/13102818.2018.1544034","article-title":"Effectiveness of dual-wavelength (Diodes 980 Nm and 635 Nm) laser approach as a non-surgical modality in the management of periodontally diseased root surface: a pilot study.","volume":"32","author":"N De Angelis","year":"2018","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"4-10","DOI":"10.4172\/2161-1122.1000514","article-title":"Effects and Action Mechanism of Low Level Laser Therapy (LLLT): Applications in Periodontology.","volume":"08","author":"I Karoussis","year":"2018","journal-title":"Dentistry."},{"key":"ref6","first-page":"110-119","article-title":"Esthetic management of mucogingival defects after total excision in a case of pyogenic granuloma.","volume":"7","author":"T Joda","year":"2012","journal-title":"Eur. J. Esthet. Dent."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"046-050","DOI":"10.1055\/s-0039-1688102","article-title":"A Case Report: Aggressive Pyogenic Granuloma.","volume":"07","author":"D Kumar","year":"2019","journal-title":"Dent. J. Adv. Stud."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"76-81","DOI":"10.15171\/jlms.2018.16","article-title":"LANAP, Periodontics and Beyond: A Review.","volume":"9","author":"A Jha","year":"2018","journal-title":"J. Lasers Med. Sci."},{"key":"ref9","first-page":"56-63","article-title":"Diode Laser - A Novel Therapeutic Approach in the Treatment of Chronic Periodontitis in Type 2 Diabetes Mellitus Patients: A Prospective Randomized Controlled Clinical Trial.","volume":"10","author":"S Chandra","year":"2019","journal-title":"J. Lasers Med. Sci."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-883\/v3\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-883\/v3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-883\/v3\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T10:25:13Z","timestamp":1665138313000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-883\/v3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,7]]},"references-count":9,"URL":"https:\/\/doi.org\/10.12688\/f1000research.122693.3","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.139459.r152706","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,7]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-883\/v3#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.134716.r146326, Kenneth Luk, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China, 17 Aug 2022, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/11-883\/v1#referee-response-146326","order":0,"name":"referee-response-146326","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Sajee Sattayut<\/b>; \n<i>Posted: 28 Aug 2022<\/i>; Many thanks for your comment on expanding the details of LANAP in terms of the development of techniques. We will add these to the manuscript.","URL":"https:\/\/f1000research.com\/articles\/11-883\/v3#referee-comment-8688","order":1,"name":"referee-comment-8688","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Sajee Sattayut<\/b>; \n<i>Posted: 04 Sep 2022<\/i>; \n<b>Reviewer: Ken Luk<\/b> \n<i>In this case report, the treatment protocol with wavelengths were well thought out. Laser parameters and techniques were well documented. Patient management was comprehensive.<\/i> \n<b>Response:<\/b>\n<i> <\/i>Many thanks for your kind consideration.  \n<i>Pulsed Nd:YAG (1064nm) laser for LANAP&nbsp; protocol was cleared by the FDA in 2004.1 Yukna demonstrated LANAP&nbsp; protocol with Nd:YAG laser can produce new cementum-mediated connective tissue attachment.2 Recently,&nbsp; LANAP seem to be broadened to include near-infra-red diode wavelengths.3<\/i>  \n<i>In this report, 980nm diode laser was used for LANAP protocol in step 1 and 2. Photodynamic therapy (PDT) with 635nm red laser was used in step 3. The initial LANAP protocol uses only Nd:YAG laser and no PDT was required. It would be more appropriate to describe the LANAP protocol in this case report as a modified LANAP protocol.<\/i>  \n<i>Alternative lasers for this case: Like 980nm, 810nm, 940nm and 970nm are also well absorbed by haemoglobin and melanin. They can also be used for ablation, coagulation and photobiomodulation. Instead of PDT, photothermal therapy can be considered using Indocyanine green as a photosensitiser with 810nm diode laser<\/i>.  \n<b>Response: <\/b>Your suggestion on emphasizing the modification of LANPP technique used for this case report was added in a discussion. Regarding the LANAP used in this case report, it was based on the techniques of De Angelis el al \n<sup>4 <\/sup>which combined photoablation and photodynamic therapy. This differed from other LANAP techniques by using only either Nd;YAG laser\n<sup>8<\/sup> or diode laser\n<sup>9<\/sup> for ablating epithelium and granulation tissue in the gingival pocket and root resurface.  Owing to this being a case report, we would like to reserve other types of lasers or photosensitizers to be claimed that these would be applied as similar results have been proved in this study.&nbsp;  \n<i>References 1. Gregg II R. H: The LANAP Protocol: laser-assisted new attachment procedure. International Journal of Periodontics and Restorative Dentistry. 2007. 87 2. Yukna RA, Carr RL, Evans GH: Histologic evaluation of an Nd:YAG laser-assisted new attachment procedure in humans.Int J Periodontics Restorative Dent. 2007; 27 (6): 577-87 PubMed Abstract 3. Shetty A, Ramachandra V. K, Shubhashini N. S, Anjali K, et al.: Diode laser assisted management of endo-perio lesion in maxillary incisor using LANAP: A Case Report. International Dentistry South Africa. 2010. 38-43<\/i>  \n<b>Response<\/b>: We could not find your suggested references in the Pubmed database. The references in the Pubmed database that supported the same ideas as you suggested were included. Jha A, Gupta V, Adinarayan R: LANAP, Periodontics and Beyond: A Review. J Lasers Med Sci. 2018;9(2):76-81. Chandra S, Shashikumar P: Diode Laser - A Novel Therapeutic Approach in the Treatment of Chronic Periodontitis in Type 2 Diabetes Mellitus Patients: A Prospective Randomized Controlled Clinical Trial. J Lasers Med Sci. 2019;10(1):56-63.","URL":"https:\/\/f1000research.com\/articles\/11-883\/v3#referee-comment-8726","order":2,"name":"referee-comment-8726","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.138280.r149597, Samir Namour, Laser Application in Dental Medicine, Department of Dental Sciences, Faculty of Medicine, University of Liege, Liege, Belgium, 07 Sep 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-883\/v2#referee-response-149597","order":3,"name":"referee-response-149597","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Sajee Sattayut<\/b>; \n<i>Posted: 04 Oct 2022<\/i>; We feel very grateful for your kind and keen suggestion. The modification was made as follows:-  This treatment was then immediately followed by treatment with using a 635 nm diode laser via an 8 mm optical fiber at 100 mW, continuous wave and 4 J\/cm \n<sup>2<\/sup> with non contact mode to the lesion at the buccal and lingual sites for 1 session per area to achieve photobiomodulation (Figure 5). It was interesting that an initial blood clot was also observed over the irradiated area.  We just would like to report an interesting result on blood clot formation after photobiomodulation. Your suggestion is true. The dose which we used would not produce any photothermal effect.","URL":"https:\/\/f1000research.com\/articles\/11-883\/v3#referee-comment-8858","order":4,"name":"referee-comment-8858","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work is supported by The Lasers in Dentistry Research Group, Khon Kaen University, Thailand. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":5,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}