{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:05:56Z","timestamp":1772168756992,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.122851.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000}}],"reference-count":40,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background<\/ns3:bold>\n                    : Coffee is a popular non-alcoholic beverage consumed by humans across the world. It contains caffeine, which is a type of stimulant of the central nervous system. In the auditory system, it has a positive effect on auditory brainstem response and perception of speech in noise. Further, caffeine has an inhibitory effect in the cochlea, but studies have rarely investigated its effect on otoacoustic emissions (OAEs) in humans. OAEs are low-intensity sounds produced by the cochlea, which could be recorded in the ear canal. The present study was carried out to investigate the effect of coffee on transient evoked otoacoustic emission (TEOAE) and contralateral suppression of TEOAE.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Method<\/ns3:bold>\n                    : A total of 52 young adults participated in the study. A cross-over study design was used for the present investigation. The TEOAE and contralateral suppression of TEOAE were recorded before and after consumption of coffee and milk. The contralateral suppression of TEOAE was measured by presenting white noise to the contralateral ear at 40, 50, and 60 dB sound pressure level (SPL).\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Results<\/ns3:bold>\n                    : The mean amplitude of TEOAE before and after consumption of coffee was similar in both ears. Further, the mean contralateral suppression of TEOAE was slightly larger after consumption of coffee in both ears. However, the mean difference was not significant in both the ears.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusions<\/ns3:bold>\n                    : Based on the findings of present study, coffee has no significant effect on the amplitude of TEOAE and contralateral suppression of TEOAE.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.122851.2","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T13:00:09Z","timestamp":1694610009000},"page":"878","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of coffee on contralateral suppression of transient evoked otoacoustic emissions"],"prefix":"10.12688","volume":"11","author":[{"given":"Ishaan","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9984-9175","authenticated-orcid":false,"given":"Mohan Kumar","family":"Kalaiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritik","family":"Roushan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usha","family":"Shastri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushlendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.3390\/nu10101429","article-title":"Association of coffee consumption with hearing and tinnitus based on a national population-based survey.","volume":"10","author":"S Lee","year":"2018","journal-title":"Nutrients."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1-30","DOI":"10.1080\/0265203021000007840","article-title":"Effects of caffeine on human health.","volume":"20","author":"P Nawrot","year":"2003","journal-title":"Food Addit. 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Based on your recommendations, manuscript has been modified. See details below:  Introduction: \n<b>Reviewer comment:<\/b> Several sentences in the introduction should be backed up by references, e.g.: \u201cIn the cochlea, the OAEs are produced spontaneously and also in response to an external acoustic stimuli, referred as spontaneous OAEs and evoked OAEs respectively.\u201d \u201cThe OAEs elicited in response to pure-tones are known as distortion product OAEs (DPOAEs) and stimulus frequency OAEs (SFOAEs).\u201d \u201cThe suppression of OAE obtained by presenting noise to the non-test ear is known as the contralateral suppression of OAE.\u201d The authors refer to review by Guinan, but he uses term of inhibition not suppression and it is directly stated why in the referenced paper. This should be at least commented. \n<b>Authors reply: <\/b>Citations added to the manuscript&nbsp;  Method: \n<b>Reviewer comment:<\/b> How much caffeine was in the coffee? Please provide information of the amount of caffeine used for the experiments. \n<b>Authors reply: <\/b>The caffeine content ranges from 2.2 to 3.1%. Thus, the amount of caffeine ranged from 27 to 40 mg per cup of coffee. Same information is added to the manuscript. &nbsp;  \n<b>Reviewer comment: <\/b>It would be good if the authors evaluated effect of coffee by some other test, to show that coffee influenced the subject at all, e.g. in studies of effect of attention on OAEs the attention level is evaluated by counting of stimuli or by evoked potentials, and then OAE analyses are made. \n<b>Authors reply:<\/b> We agree with your recommendation, but other tests were not performed during the study. We acknowledge the same in discussion&nbsp;  \n<b>Reviewer comment<\/b>: How the authors evaluated the middle ear muscle reflex (MEMR)? Several studies point to MEMR interaction with experiments based on contralateral suppression of OAEs. The authors should check the MEMR influence or at least mention lack of it as the limitation of the study. \n<b>Authors reply:<\/b> The middle ear muscle reflex was evaluated by measuring the acoustic reflex threshold for white noise. GSI Tympstar Pro immittance meter was used for measuring the reflex threshold for white noise. The lowest intensity at which a change in admittance was noted (referred as \u2018reflex threshold\u2019) was considered as an evidence of middle ear muscle reflex. In the present study the white noise was presented below the reflex threshold, during the measurement of contralateral suppression of TEOAE. Similar approach has been employed by several studies measuring the contralateral suppression of TEOAE. &nbsp;  \n<b>Reviewer comment:<\/b> Why are OAE parameters calculated by some program, and not taken from the ILO system? \n<b>Authors reply:<\/b> During the study period, the computer used for recording and storing the OAE data failed. Data was not lost, as data files were copied to another computer. We could not find a way to load the data files back to ILO software platform for the purpose of data analysis. Thus, OAE parameters was calculated using EchoMaster software. &nbsp;  \n<b>Reviewer comment: <\/b>Provide some rationale for using 3 dB SNR criterion while studies of reliability of OAE suppression recommend using at least 6 dB or even more. \n<b>Authors reply: <\/b>We have reanalyzed the data and presented results using 6 dB SNR criterion. &nbsp; Results: \n<b>Reviewer comment: <\/b>Please provide error bars on figures 4 and 5. \n<b>Authors reply: <\/b>Error bars (SD) added to figure 4. Data showed in figure 5 is same as figure 4. &nbsp; \n<b>Reviewer comment: <\/b>Maybe the authors could select smaller dataset with OAEs of SNR &gt; 6dB? \n<b>Authors reply: <\/b>We have reanalyzed the data and presented results using 6 dB SNR criterion. &nbsp;  Discussion: \n<b>Reviewer comment: <\/b>Study is based on TEOAEs so the comparisons to DPOAEs should be limited. \n<b>Authors reply:<\/b> As studies related to TEOAEs are not available in literature, DPOAEs are cited for the purpose of comparison. &nbsp;  Please compare results with other studies of suppression on same equipment, especially recent studies of reliability\/variability. Even if there are no studies of coffee on suppression of OAEs, there are some studies of reliability of TEOAEs measured by the same equipment. These are very good basis for comparison, and for reference what change in TEOAE suppression would show the significant effect.  References: \n<b>Reviewer comment:<\/b> Mistakes \u2013 references to papers in which there is no referenced information. For example: \u201cFurther, the OAEs elicited in response to short-duration stimuli such as clicks and tone-bursts are known as transient evoked OAEs (TEOAEs).\u201d which cites Kemp 1978. At this time Kemp did not used the name of TEOAEs. \n<b>Authors reply:<\/b> Citation changed and error corrected","URL":"https:\/\/f1000research.com\/articles\/11-878\/v2#referee-comment-10149","order":1,"name":"referee-comment-10149","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.155503.r206292, Chhayakant Patro, Department of Speech-Language Pathology & Audiology, Towson University, Towson, MD, 06 Oct 2023, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-878\/v2#referee-response-206292","order":2,"name":"referee-response-206292","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.155503.r206294, Sandeep Maruthy, Department of Audiology, All India Institute of Speech and Hearing, Mysuru, Karnataka, 11 Oct 2023, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-878\/v2#referee-response-206294","order":3,"name":"referee-response-206294","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}