{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:06:56Z","timestamp":1772168816783,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.122952.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000}},{"DOI":"10.12688\/f1000research.122952.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000}}],"reference-count":10,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>We reported the observation of a 31-year-old female followed for a nasopharyngeal carcinoma since 2009, treated by locoregional radiotherapy, with a cumulative dose of 75 Gray. The patient presented with a progressive decline in bilateral vision. Ophthalmologic examination revealed bilateral dry eye, posterior subcapsular cataract, radiation retinopathy, and optic neuropathy. The patient presented all ocular complications of radiotherapy. The most severe was radiation retinopathy. Performing optic coherence tomography angiography (OCT-A) earlier could have speeded up the diagnosis and led to a better prognosis.<\/ns3:p>\n                  <ns3:p>The OCT-A showed more pronounced macular edema in the right eye, and revealed enlargement of the central avascular zone and loss of the deep and superficial retinal vascular network. The patient received three consecutive monthly intravitreal injections of anti-vascular endothelial growth factor. Yet, we noted a non-improved visual acuity.<\/ns3:p>\n                  <ns3:p>The aim of this case report was to present the contribution of OCT-A in the diagnosis of radiation maculopathy and attribute these changes to ischemia at the level of the retinal vascular network.<\/ns3:p>","DOI":"10.12688\/f1000research.122952.3","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T09:55:09Z","timestamp":1695635709000},"page":"968","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Optical coherence tomography angiography findings in radiation retinopathy"],"prefix":"10.12688","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-7171","authenticated-orcid":false,"given":"Wafa","family":"Ammari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2075-1050","authenticated-orcid":false,"given":"Asma","family":"Zaghdoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olfa","family":"Berriche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riadh","family":"Messaoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"ref1","first-page":"630880","article-title":"Radiation-Induced Optical Coherence Tomography Angiography Retinal Alterations in Patients with Nasopharyngeal Carcinoma.","volume":"7","author":"L Zijing","year":"2020","journal-title":"Front Med (Lausanne)."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"417-423","DOI":"10.4143\/crt.2021.575","article-title":"Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect.","volume":"54","author":"O Akagunduz","year":"2021","journal-title":"Cancer Res Treat."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e727-e731","DOI":"10.1111\/aos.13797","article-title":"Retinal perfusion changes in radiation retinopathy.","volume":"96","author":"K Rose","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"100918","DOI":"10.1016\/j.ajoc.2020.100918","article-title":"PAMM and the ischemic cascade associated with radiation retinopathy.","volume":"20","author":"D Wang","year":"2020","journal-title":"Am J Ophthalmol Case Report."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"320-326","DOI":"10.1016\/j.oret.2019.10.001","article-title":"Longitudinal Detection of Radiation-Induced Peripapillary and Macular Retinal Capillary Ischemia Using OCT Angiography.","volume":"4","author":"A Skalet","year":"2020","journal-title":"Retina."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100951","article-title":"Retinal applications od swept source optical coherence tomography (OCT) and optical coherence tompgraphy angiography (OCT-A).","volume":"84","author":"I Lains","year":"2021 Sep","journal-title":"Prog Retinin Eye Res."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"869-878","DOI":"10.1007\/s00417-020-04618-7","article-title":"Influence of Ranibizumab versus laser photocoagulation on radiation retinopathy (RadiRet) - a prospective randomized controlled trial.","volume":"258","author":"I Seibel","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"441-460","DOI":"10.1016\/j.survophthal.2020.08.007","article-title":"Treatment of radiation maculopathy and radiation-induced macular edema: A systemic review.","volume":"66","author":"M Fallico","year":"2021","journal-title":"Surv Ophthalmol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1660-1673","DOI":"10.1097\/IAE.0000000000001414","article-title":"Image Quality and Artifacts on Optical Coherence Tomography Angiography: Comparison of Pathologic and Paired Fellow Eyes in 65 Patients with Unilateral Choroidal Melanoma Treated with Plaque Radiotherapy.","volume":"37","author":"T Say","year":"2017","journal-title":"Retina."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"157-166","DOI":"10.1097\/ICU.0000000000000141","article-title":"Current treatments and preventive strategies for radiation retinopathy.","volume":"26","author":"D Reichstein","year":"2015","journal-title":"Curr Opin Ophthalmol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-968\/v3\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-968\/v3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-968\/v3\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T11:30:08Z","timestamp":1745235008000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-968\/v3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,25]]},"references-count":10,"URL":"https:\/\/doi.org\/10.12688\/f1000research.122952.3","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.122952.2","asserted-by":"subject"},{"id-type":"doi","id":"10.12688\/f1000research.122952.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.156359.r209186","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.156359.r209187","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.156359.r209187","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.156359.r209186","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,25]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-968\/v3#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.156359.r209187, Helmi Ben Saad, Faculty of Medicine of Sousse, Laboratory of Physiology, University of Sousse, Sousse, 26 Sep 2023, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/11-968\/v3#referee-response-209187","order":0,"name":"referee-response-209187","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.156359.r209186, David Sol\u00e1-Del Valle, Department of Ophthalmology, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, MA, 26 Sep 2023, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/11-968\/v3#referee-response-209186","order":1,"name":"referee-response-209186","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}