{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T08:55:59Z","timestamp":1793436959648,"version":"4.5.0"},"update-to":[{"DOI":"10.12688\/f1000research.123104.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000}}],"reference-count":36,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Introduction:<\/ns4:bold>\n                    The purpose of this study was to compare iCare HOME (TA022) with Goldmann applanation tonometer and to evaluate the self-tonometry measurements among the Indian population.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    Eligible patients underwent iCare HOME training through guided demonstration (verbal, pictorial, video) and practised self-tonometry measures using iCare HOME. Certification for independent iCare HOME measure was provided if first iCare HOME intraocular pressure (IOP) measurement fell within \u00b1 5 mmHg of Goldmann applanation tonometer (GAT)\u00a0measurement which was measured by the trained clinician (principal investigator). Certified participants underwent simulated home self-tonometry measurements using iCare HOME, and agreement with GAT IOP measurements was assessed.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    Seven of 83 participants (8.43%) failed to complete the study due to difficulty in performing the task, leading to non-certification. Patients who could use the iCare HOME had a mean age of 53 \u00b1 15.55years (53% males; 46% females). Only one in 12 subjects did not qualify\u00a0to use iCare HOME. The overall mean difference between iCare HOME and GAT was 0.83 mmHg (95%, 3.92 and -2.25) with 94.7% agreement. At various pressure ranges, 7-16 mmHg, 17-23 mmHg and &gt;23 mmHg, the mean difference between iCare HOME and GAT was 1.22 mmHg (95%, 4.32 and -1.86) with 97.4% agreement, 0.77 mmHg (95%,3.69 and -2.19) with 91.3% agreement, -0.11 mmHg (95%, 2.52 and -2.74) with 100% agreement respectively. The intra-class correlation coefficient of the iCare HOME device was 0.997(95% CI,0.995-0.998).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    \u00a0\u00a0Patients were able to perform self- tonometry using iCare HOME with good reliability and safety. iCare HOME shows good agreement with GAT. Further studies with proper home environment will be recommended to study the diurnal comparisons with GAT.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.123104.2","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T12:05:07Z","timestamp":1695384307000},"page":"128","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Performance of home-based self-tonometry (iCare HOME (TA022)) for measuring intraocular pressure among healthy and glaucoma patients"],"prefix":"10.12688","volume":"12","author":[{"given":"Anush","family":"Nayak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7592-9151","authenticated-orcid":false,"given":"S Ve","family":"Ramesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7297-829X","authenticated-orcid":false,"given":"Neetha I R","family":"Kuzhuppilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya H","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5660-3826","authenticated-orcid":false,"given":"Aditya","family":"Chaitanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"481-517","DOI":"10.1007\/s12325-016-0302-0","article-title":"24-h Efficacy of Glaucoma Treatment Options.","volume":"33","author":"A Konstas","year":"2016","journal-title":"Adv. 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Hyg."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"251584141983573","DOI":"10.1177\/2515841419835731","article-title":"Comparison of rebound tonometry and non-contact airpuff tonometry to Goldmann applanation tonometry.","volume":"11","author":"G Demirci","year":"2019","journal-title":"Ther Adv Ophthalmol."},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.7910\/DVN\/RXRXLS","article-title":"Performance of Home-based self-tonometry (I care HOME (TA022) for measuring intraocular pressure among Normal and Glaucoma patients.","author":"A Akkali","year":"2022"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-128\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-128\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-128\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T05:07:16Z","timestamp":1718600836000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-128\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,22]]},"references-count":36,"URL":"https:\/\/doi.org\/10.12688\/f1000research.123104.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.123104.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.156214.r208647","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.156214.r263368","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.156214.r263368","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.156214.r208647","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,22]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-128\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.135174.r162324, Bhaskaran Mani, Sujatha V, Glaucoma Services, Sankara Nethralaya, Chennai, Tamil Nadu, 14 Mar 2023, version 1, 2 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/12-128\/v1#referee-response-162324","order":0,"name":"referee-response-162324","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Aditya Chaitanya<\/b>; \n<i>Posted: 17 Sep 2023<\/i>; Dear Sir, &nbsp;We thank you for your thoughtful and constructive review of our paper. Your reviews have helped us make important additions and changes to our manuscript (outlined below). We have added these changes in the latest submitted version of article. &nbsp;Kindly please go through it.  With kind regards,  Aditya Chaitanya (on behalf of all authors). _____________________________________  Response to Comments:  1. Abstract:&nbsp; Conclusion - &quot;iCare HOME can be used to address the issue of difficulty in acquiring frequent and diurnal IOP measurements by patients doing self\n<u> <\/u>tonometry from home&quot;. This is not studied, Preferable to say agreement with GAT or not. Then suggest diurnal study comparisons may be warranted,  \n<b>Modification:<\/b> &nbsp; \n<b>&quot;Patients were able to perform self- tonometry using iCare HOME with good reliability and safety. iCare HOME shows good agreement with GAT. Further studies with proper home environment will be recommended to study the diurnal comparisons with GAT.&quot;<\/b>  2. Abstract Results: Please provide Bland Altman 95% agreement limit values instead of mean difference and 95% of mean values, it may be misleading.  \n<b>We have provided the Bland-Altman 95% agreement limit values in both abstract and results sections in the latest submitted version.<\/b>  3. Introduction - &quot;Recent guidelines on post-coronavirus disease 2019 (COVID-19) glaucoma care recommend the use of a rebound tonometer&quot; - Provide the reference for this.  \n<b>Modification:<\/b> &nbsp;\u2018\n<b>'Considering the current post-coronavirus disease 2019 (COVID-19) pandemic rebound tonometer will be the best IOP measuring device for patient safety and less contamination risk&quot;.<\/b>  4. Methods: Inclusion criteria: Mention healthy and glaucoma patients - Define both clearly. Provide the break up of the glaucoma cases as proper diagnosis in results.&nbsp; &nbsp;  \n<b>Modification:<\/b> \n<b>Glaucoma patients inclusion criteria: &quot;Patients with structural glaucomatous optic disc changes that include RNFL defects, loss of neuro retinal rim, disc haemorrhages, disc asymmetry more than 0.2, &nbsp;&nbsp;with or without corresponding functional visual field changes were categorised as glaucoma&quot;.&nbsp; - same mentioned in the methods sections.<\/b>  5. Methods: Patients were provided video instructions - Please provide a link to the same or mention if it is from the manufacturer.&nbsp;  \n<b>Modification:<\/b> &quot;\n<b>We have made a detailed video showing usage of iCare Home with proper instructions and easy to understand as per the language preferences. This video was approved by the manufacturer to use in iCare Home related studies.&quot;&nbsp; - same mentioned in the methods sections.<\/b>  6.Methods: Mention Icae LINK software or otherwise in full with manufacturer name for the first time.  \n<b>Modification:&nbsp; &quot;http:\/\/www.icarefinland.com\/products\/icare-link\/.&quot;&nbsp; -Mentioned this link in the methodology section.<\/b>  7.Table 1 - Age group has a large SD, please provide the median and range as well.  \n<b>We have provided Median and range for age group in table - 1.&nbsp;<\/b>  8.Figures 1 and 2 - Is the X axis should be Mean of Icare Home and GAT, rather than GAT mean only?  \n<b>Both&nbsp;Figure-1&nbsp;and Figure -2&nbsp; Modified as per your suggestion<\/b>  9. Figure 2 - Mention N in each subgroup.  \n<b>Mentioned N in each subgroup in Figure-2.<\/b>  10. Table 3: Check title and correct sentence.&nbsp;  \n<b>Modification: &quot;iCare Home findings comparison between two different groups of Palpebral fissure height and Exophthalmometry.&quot; This table renamed as Table-4.&nbsp;<\/b>  11.Discussion: Segregate RBT studies and Icare Home studies. Both are different and serve different purposes.  \n<b>Slightly modified as per your suggestion. Second paragraph of the discussion section initially discusses about RBT studies and its reliability. Latter part, discusses about iCare ONE studies. Rest of discussion section particularly discusses about iCare Home studies.<\/b>  12. Discussion should address the strengths and limitations of your study, besides the LOA in Bland Altmann need to be discussed in the context of repeatability. CCT influence is not studied.  \n<b>Modification:&nbsp; Limitations: &quot; One of the &nbsp;limitations of the study is that we have performed this study, i.e. validation of iCare Home, in a simulated home environment at hospital set up. Even though each patient underwent proper training and had a simulated home environment, it may not produce the same results as regular home environment. It also does not address the &nbsp;learning effect that comes from use over a period of time. So, the future studies should focus on validation of iCare home through a real time home\/work place environment. It helps to understand both regular short term and long term diurnal fluctuations of IOP of the patients.&quot;&nbsp; - same mentioned in discussion section .<\/b>","URL":"https:\/\/f1000research.com\/articles\/12-128\/v2#referee-comment-10238","order":1,"name":"referee-comment-10238","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.156214.r208647, Rashima Asokan, Elite School of Optometry, Medical Research Foundation, Chennai, 17 Jun 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-128\/v2#referee-response-208647","order":2,"name":"referee-response-208647","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.156214.r263368, Tiina Pesonen, University of Oulu, Oulu, 13 Apr 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-128\/v2#referee-response-263368","order":3,"name":"referee-response-263368","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}