{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:47:24Z","timestamp":1790275644267,"version":"4.1.0"},"reference-count":60,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI116983"],"award-info":[{"award-number":["AI116983"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Both actin and microtubules are major cytoskeletal elements in eukaryotic cells that participate in many cellular processes, including cell division and motility, vesicle and organelle movement, and the maintenance of cell shape. Inside its host cell, the human pathogen <ns4:italic>Chlamydia trachomatis <\/ns4:italic>manipulates the cytoskeleton to promote its survival and enhance its pathogenicity. In particular,<ns4:italic> Chlamydia<\/ns4:italic> induces the drastic rearrangement of both actin and microtubules, which is vital for its entry, inclusion structure and development, and host cell exit. As significant progress in <ns4:italic>Chlamydia<\/ns4:italic> genetics has greatly enhanced our understanding of how this pathogen co-opts the host cytoskeleton, we will discuss the machinery used by <ns4:italic>Chlamydia<\/ns4:italic> to coordinate the reorganization of actin and microtubules.<\/ns4:p>","DOI":"10.12688\/f1000research.12316.1","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T03:55:07Z","timestamp":1511927707000},"page":"2058","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Taking control: reorganization of the host cytoskeleton by 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