{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T14:39:48Z","timestamp":1782052788163,"version":"3.54.5"},"reference-count":6,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Porphyria cutanea tarda (PCT) is a complex metabolic disease resulting from altered activity of the enzyme uroporphyrinogen decarboxylase (UROD) in the liver resulting in accumulation of uroporphyrin. PCT presents as a blistering photodermatitis with skin fragility, vesicles, scarring and milia.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Case:<\/ns4:bold>\n                    We report a case of PCT in a 67-year-old man with hemochromatosis\u00a0(HFE) gene mutation who, following a major syncopal episode in response to venesection was commenced on low dose hydroxychloroquine.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    Low dose hydroxychloroquine provided a safe and effective alternative to venesection in this patient who was needle phobic.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.124022.1","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T06:55:08Z","timestamp":1660719308000},"page":"945","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Treatment of porphyria cutanea tarda with low dose hydroxychloroquine"],"prefix":"10.12688","volume":"11","author":[{"given":"Andrew","family":"Awad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Nirenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6751-1428","authenticated-orcid":false,"given":"Rodney","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"880-893","DOI":"10.1111\/j.1478-3231.2012.02794.x","article-title":"Hepatitis C, porphyria cutanea tarda and liver iron: an update.","volume":"32","author":"F Ryan Caballes","year":"2012","journal-title":"Liver Int."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"297-302.e1","DOI":"10.1016\/j.cgh.2009.11.017","article-title":"Associations among behavior-related susceptibility factors in porphyria cutanea tarda.","volume":"8","author":"S Jalil","year":"2010","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1464-1480","DOI":"10.1111\/ijd.12305","article-title":"Cutaneous porphyrias part I: epidemiology, pathogenesis, presentation, diagnosis, and histopathology.","volume":"52","author":"M Horner","year":"2013","journal-title":"Int. J. Dermatol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"109-125","DOI":"10.1093\/alcalc\/35.2.109","article-title":"Alcohol and porphyrin metabolism.","volume":"35","author":"M Doss","year":"2000","journal-title":"Alcohol Alcohol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1402-1409","DOI":"10.1016\/j.cgh.2012.08.038","article-title":"Low-dose hydroxychloroquine is as effective as phlebotomy in treatment of patients with porphyria cutanea tarda.","volume":"10","author":"A Singal","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"309-313","DOI":"10.1001\/archderm.139.3.309","article-title":"Hemochromatosis (HFE) gene mutations and response to chloroquine in porphyria cutanea tarda.","volume":"139","author":"U St\u00f6lzel","year":"2003","journal-title":"Arch. Dermatol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-945\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-945\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-945\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T10:35:12Z","timestamp":1686220512000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-945\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,17]]},"references-count":6,"URL":"https:\/\/doi.org\/10.12688\/f1000research.124022.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.136191.r172322","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.136191.r172317","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.136191.r156729","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.136191.r156729","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.136191.r172322","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.136191.r172317","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,17]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-945\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.136191.r156729, Jordi To-Figueras, Clinical Biochemistry Department, Hospital Clinic of Barcelona, Faculty of Medicine, University of Barcelona, Barcelona, 16 Dec 2022, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/11-945\/v1#referee-response-156729","order":0,"name":"referee-response-156729","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.136191.r172317, Staffan Wahlin, Department of Upper GI Diseases, Karolinska University, Stockholm, 23 May 2023, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/11-945\/v1#referee-response-172317","order":1,"name":"referee-response-172317","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.136191.r172322, Andrea Ricci, Department of Medical and Surgical Science for Children and Adults, Universita degli Studi di Modena e Reggio Emilia, Modena, Emilia-Romagna, 08 Jun 2023, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/11-945\/v1#referee-response-172322","order":2,"name":"referee-response-172322","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}