{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:22:05Z","timestamp":1793013725912,"version":"4.5.0"},"reference-count":85,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation in Vaccine Preventable Diseases"},{"name":"Medical Research Council"},{"name":"South African Research Chairs Initiative of the Department of Science and Technology"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>The influenza virus circulates yearly and causes global epidemics. Influenza infection affects all age groups and causes mild to severe illness, and young infants are at particular risk for serious disease. The most effective measure to prevent influenza disease is vaccination; however, no vaccine is licensed for use in infants younger than 6 months old. Thus, there is a crucial need for other preventive strategies in this high-risk age group. Influenza vaccination during pregnancy protects both the mothers and the young infants against influenza infection. Vaccination during pregnancy boosts the maternal antibodies and increases the transfer of immunoglobulin G from the mother to the fetus through the placenta, which confers protection against infection in infants too young to be vaccinated. Data from clinical trials and observational studies did not demonstrate adverse effects to the mother, the fetus, or the infant after maternal influenza vaccination. We present the current data on the effectiveness and safety of influenza vaccination during pregnancy in preventing disease in the young infant.<\/ns4:p>","DOI":"10.12688\/f1000research.12473.1","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T11:25:19Z","timestamp":1517225119000},"page":"122","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":48,"title":["Prevention of influenza-related illness in young infants by maternal vaccination during pregnancy"],"prefix":"10.12688","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-878X","authenticated-orcid":false,"given":"Marta C","family":"Nunes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabir 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.13506.r30114, Ross Andrews, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia, 29 Jan 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-122\/v1#referee-response-30114","order":0,"name":"referee-response-30114","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.13506.r30113, G\u00fclsah Gabriel, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany, 29 Jan 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-122\/v1#referee-response-30113","order":1,"name":"referee-response-30113","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was partially supported by the South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation in Vaccine Preventable Diseases; and the Medical Research Council: Respiratory and Meningeal Pathogens Research Unit. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}