{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:29:15Z","timestamp":1791556155635,"version":"4.3.4"},"update-to":[{"DOI":"10.12688\/f1000research.124960.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000}},{"DOI":"10.12688\/f1000research.124960.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000}},{"DOI":"10.12688\/f1000research.124960.3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000}}],"reference-count":101,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns7:p>About 10 to 20% of reported pregnancies have complications like spontaneous abortion (SA), preeclampsia (PE), preterm birth (PTB), and fetal growth restriction (FGR); 60% are attributed to maternal nutritional alterations. Multiple micronutrients (MMN) are supplemented in the antenatal period, but no proper validation\/guidelines are available regarding dosing\/time, the need for initiation, and the duration of supplementation. Studies have reported adverse pregnancy complications related to the overuse\/unwanted use of multiple micronutrient supplementations during pregnancy. Identifying the exact population requiring supplementation is necessary to prevent its abuse. This article attempts to review the impacts of micronutrient deficiency\/supplementation in cases of SA, FGR, and gestational diabetes mellitus (GDM), preterm delivery and PE. The study used a literature search using PubMed, Google Scholar, Mendeley, and Scopus Databases using search words pregnancy, spontaneous abortion, gestational diabetes mellitus (GDM), fetal growth restriction (FGR), preterm delivery, preeclampsia (PE) or \u201cadverse pregnancy\u201d associated with minerals, micronutrients, or supplementation. The review also considered in-house literature databases, a single-window search at Kasturba Medical College (KMC) Health sciences library, MAHE (Manipal Academy of Higher Education). The figures included in the study were created by Biorender.com. Micronutrients play multiple roles during pregnancy and fetoplacental growth stimulating growth hormone secretion, Lysyl oxidase (LOX), involved in the crosslinking between collagen and elastin in the amniotic membrane, downregulation of interleukin (IL)-1 alpha, IL-1 beta, IL-4, IL-6, Il-10, IL-12, tumor necrosis factor (TNF)-alpha and several chemokines involved in hypertension, immune-inflammatory pathways, attenuate insulin resistance, structural development of neurons and glia. Over-supplementation has led to complications such as spontaneous abortion and gestational diabetes mellitus. Since there is a lack of standardization concerning micronutrient supplementation during pregnancy, there is a need for systematic study related to the role of micronutrients during each trimester of pregnancy to optimize its supplementation and to prevent hazards associated with its abuse.<\/ns7:p>","DOI":"10.12688\/f1000research.124960.4","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T06:13:08Z","timestamp":1718950388000},"page":"1369","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Micronutrients in Adverse Pregnancy Outcomes"],"prefix":"10.12688","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-3569","authenticated-orcid":false,"given":"Sairoz","family":".","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3479-9597","authenticated-orcid":false,"given":"Krishnananda","family":"Prabhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6773-1113","authenticated-orcid":false,"given":"Ranita Ghosh","family":"Dastidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annayya Rao","family":"Aroor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahadev","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahana","family":"shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5972-9945","authenticated-orcid":false,"given":"Vidyashree G","family":"Poojari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-3550","authenticated-orcid":false,"given":"Varashree","family":"BS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2106-2116","DOI":"10.1016\/j.jacc.2018.12.092","article-title":"Long-Term Cardiovascular Risks Associated With Adverse Pregnancy Outcomes: JACC Review Topic of the Week.","volume":"73","author":"A Lane-Cordova","year":"2019 Apr 30","journal-title":"J. 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I shall accordingly include these suggestions and revert soon. This will go a long way in enriching this review article&nbsp;  Regards,","URL":"https:\/\/f1000research.com\/articles\/11-1369\/v4#referee-comment-10373","order":1,"name":"referee-comment-10373","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Krishnananda Prabhu<\/b>; \n<i>Posted: 03 Nov 2023<\/i>; Dear Sir,  Based on your suggestions, I have edited the article. Herewith sending it today to the editorial team for further processing. I sincerely thank for your valuable inputs&nbsp;  Regards,","URL":"https:\/\/f1000research.com\/articles\/11-1369\/v4#referee-comment-10514","order":2,"name":"referee-comment-10514","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.137211.r199841, Jitendra Ahuja, Rajasthan University of Health Sciences, Jaipur, Rajasthan, 19 Jan 2024, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/11-1369\/v1#referee-response-199841","order":3,"name":"referee-response-199841","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Krishnananda Prabhu<\/b>; \n<i>Posted: 20 Jan 2024<\/i>; Dear Sir, Thank you very much for your valuable input to enrich this article. I shall do the required modification as soon as possible and resubmit for your approval. Regards,&nbsp;","URL":"https:\/\/f1000research.com\/articles\/11-1369\/v4#referee-comment-10925","order":4,"name":"referee-comment-10925","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.162687.r281711, Giovanni Tossetta, Universit\u00e0 Politecnica delle Marche, Ancona, 25 May 2024, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/11-1369\/v3#referee-response-281711","order":5,"name":"referee-response-281711","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":6,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}