{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:54Z","timestamp":1772168874688,"version":"3.50.1"},"reference-count":48,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Toxic epidermal necrosis (TEN) is rare and can be life-threatening for patients. Appropriate management of TEN patients could give optimal results and prevent complications. One treatment modality for TEN is plasmapheresis, which is rarely available in most cases with severe TEN. Here we reported a successful treatment of severe TEN with plasmapheresis. A 40-year-old woman under tuberculosis therapy complained of shortness of breath that began four days prior to hospital admission and worsened ever since. The patient's skin was peeling with red spots and rashes all over the body for a week. During the examination, the patient was compos mentis, and the SCORTEN score was 2 with 12.1% risk of mortality rate. Dermatological examination of the face, trunk and extremities found extensive erosions, loose bullae filled with clear fluid, brown crusts, and generalized distribution with more than 30% epidermolysis. The patient was diagnosed with toxic epidermal necrolysis caused by antituberculosis therapy. We treated the patient by discontinuing the suspected drugs and administering the corticosteroids, but no improvement was observed. The patient underwent two cycle plasmaphereses with 5% albumin, resulting in 1.2 liter of plasma exchange. Re-epithelialization was observed after three days, and the patient was discharged on day 8. This case-report highlights the important role of plasmapheresis in treating the TEN patients. However, a study with larger sample sizes is warranted to validate the efficacy of plasmapheresis in TEN.<\/ns4:p>","DOI":"10.12688\/f1000research.125050.1","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T10:05:06Z","timestamp":1662372306000},"page":"995","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: A successful case of toxic epidermal necrolysis treated with plasmapheresis therapy"],"prefix":"10.12688","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3119-7224","authenticated-orcid":false,"given":"Wahyu","family":"Lestari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vella","family":"Vella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teuku","family":"Yasir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teuku","family":"Zulfikar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"ref2","first-page":"43-44","article-title":"Toxic epidermal necrolysis.","volume":"96","author":"J Peters","year":"2000","journal-title":"Nurs. 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Res."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"323-326","DOI":"10.15562\/bmj.v9i1.1647","article-title":"Toxic Epidermal Necrolysis (TEN) in an elderly with comorbidities: a case report.","volume":"9","author":"P Sudarsa","year":"2020","journal-title":"Bali Med. J."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"165-168","DOI":"10.1345\/aph.1E430","article-title":"A rare case of streptomycin-induced toxic epidermal necrolysis in a patient with tuberculosis: a therapeutic dilemma.","volume":"39","author":"H Hmouda","year":"2005","journal-title":"Ann. Pharmacother."},{"key":"ref8","article-title":"Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus: two cases report.","volume":"38","author":"A Asmae","year":"2021","journal-title":"PAMJ."},{"key":"ref9","first-page":"363-367","article-title":"Unusual oral findings of the toxic epidermal necrolysis in an HIV-infected patient: a case report.","volume":"23","author":"V Costa","year":"2019","journal-title":"Braz. J. Infect. Dis."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"951","DOI":"10.12688\/f1000research.7574.1","article-title":"Toxic epidermal necrolysis.","volume":"5","author":"W Hoetzenecker","year":"2016","journal-title":"F1000Res."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"381-384","DOI":"10.1016\/j.jsps.2014.02.001","article-title":"Antiepileptic drugs toxicity: A case of toxic epidermal necrolysis in patient with phenytoin prophylaxis post-cranial radiation for brain metastases.","volume":"22","author":"K AlQuliti","year":"2014","journal-title":"Saudi Pharm. J."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"87-88","DOI":"10.4103\/0970-2113.92376","article-title":"Ethambutol and pyrazinamide-induced toxic epidermal necrolysis in an immunocompetent adult with tuberculosis.","volume":"29","author":"S Das","year":"2012","journal-title":"Lung India."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1-3","DOI":"10.1155\/2012\/626709","article-title":"Response to Modified Antitubercular Drug Regime and Antiretroviral Therapy in a Case of HIV Infection with Disseminated Tuberculosis with Isoniazid Induced Toxic Epidermal Necrolysis.","volume":"2012","author":"A Swami","year":"2012","journal-title":"Case Rep Infect Dis."},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00614","article-title":"Epidemiology, Mechanisms, and Diagnosis of Drug-Induced Anaphylaxis.","volume":"8","author":"M Monta\u00f1ez","year":"2017","journal-title":"Front. Immunol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1-22","DOI":"10.1155\/2018\/6431694","article-title":"An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity.","volume":"2018","author":"C Chen","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"7-26","DOI":"10.1111\/iji.12304","article-title":"Human leucocyte antigen\u2013adverse drug reaction associations: from a perspective of ethnicity.","volume":"44","author":"G Ghattaoraya","year":"2017","journal-title":"Int. J. Immunogenet."},{"key":"ref18","first-page":"156-159","article-title":"Nekrolisis Epidermal Toksik: Laporan Kasus pada Pasien Geriatri.","volume":"4","author":"D Anggraini","year":"2017","journal-title":"J. AgromedUnila."},{"key":"ref19","article-title":"Patofisiologi dan Manajemen Terapi Sindrom Stevens-Johnson (SSJ) dan Nekrolisis Epidermal Toksik.","author":"R Diana","year":"2020"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"10-16","DOI":"10.12788\/j.sder.0058","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis: clinical patterns, diagnostic considerations, etiology, and therapeutic management.","volume":"33","author":"M Mockenhaupt","year":"2014","journal-title":"Semin. Cutan. Med. Surg."},{"key":"ref21","article-title":"Penanganan Luka Pada Stevens-Johnson's Syndrome\/Toxic Epidermal Necrolysis.","author":"R Evalina","year":"2017","journal-title":"Medan."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"232-237","DOI":"10.14442\/jgfm.17.3_232","article-title":"Successful Combination Therapy Including Plasma Exchange for Severe Toxic Epidermal Necrolysis.","volume":"17","author":"T Watari","year":"2016","journal-title":"J. Gen. Fam. Med."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.22895","article-title":"A Life-Threatening Case of Torsemide-Induced Toxic Epidermal Necrolysis Associated With the Treatment of Anasarca.","volume":"14","author":"S Reddy","year":"2022","journal-title":"Cureus."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"895","DOI":"10.3390\/medicina57090895","article-title":"Stevens\u2013Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Diagnosis and Management.","volume":"57","author":"R Frantz","year":"2021","journal-title":"Medicina."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"573573","DOI":"10.3389\/fphar.2020.573573","article-title":"An Updated Review of the Diagnostic Methods in Delayed Drug Hypersensitivity.","volume":"11","author":"A Copaescu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1142-1146.e4","DOI":"10.1016\/j.jaip.2019.10.005","article-title":"Safety of cephalosporins in penicillin class severe delayed hypersensitivity reactions.","volume":"8","author":"J Trubiano","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"218-221","DOI":"10.1046\/j.1365-4362.1997.00192.x","article-title":"Plasmapheresis in toxic epidermal necrolysis.","volume":"36","author":"G Chaidemenos","year":"1997","journal-title":"Int. J. Dermatol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1307-1310","DOI":"10.1007\/s001340051063","article-title":"Lack of significant treatment effect of plasma exchange in the treatment of drug-induced toxic epidermal necrolysis?","volume":"25","author":"A Furubacke","year":"1999","journal-title":"Intensive Care Med."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"225-228","DOI":"10.1046\/j.1526-0968.2002.00409.x","article-title":"Plasma exchange in patients with toxic epidermal necrolysis.","volume":"6","author":"G Bamichas","year":"2002","journal-title":"Ther. Apher."},{"key":"ref30","first-page":"2446-2448","article-title":"Plasma exchange; a promising treatment for toxic epidermal necrolysis with AIDS [4].","volume":"18","author":"T Nomura","year":"2004","journal-title":"AIDS."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"504-510","DOI":"10.1016\/j.bjps.2004.12.007","article-title":"Intravenous immunoglobulins and plasmapheresis combined treatment in patients with severe toxic epidermal necrolysis: Preliminary report.","volume":"58","author":"M Lissia","year":"2005","journal-title":"Br. J. Plast. Surg."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"597-599","DOI":"10.1016\/j.jbspin.2007.08.013","article-title":"Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis.","volume":"75","author":"H Hassikou","year":"2008","journal-title":"Joint Bone Spine."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"180-182","DOI":"10.1111\/j.1365-4632.2008.03389.x","article-title":"Toxic epidermal necrolysis complicated by multiple intestinal ulcers.","volume":"47","author":"N Sakai","year":"2008","journal-title":"Int. J. Dermatol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"534-536","DOI":"10.1111\/j.1346-8138.2009.00770.x","article-title":"Toxic epidermal necrolysis with severe hyperbilirubinemia: Complete re-epithelialization after bilirubin reduction therapies.","volume":"37","author":"N Kamada","year":"2010","journal-title":"J. Dermatol."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"951-952","DOI":"10.1111\/j.1346-8138.2012.01534.x","article-title":"Toxic epidermal necrolysis in a 4-year-old boy successfully treated with plasma exchange in combination with methylprednisolone and i.v. immunoglobulin.","volume":"39","author":"Y Aihara","year":"2012","journal-title":"J. Dermatol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"215-220","DOI":"10.1002\/jca.21213","article-title":"Beneficial effect of plasma exchange in the treatment of toxic epidermal necrolysis: A series of four cases.","volume":"27","author":"M Ko\u0161t\u0301\u00e1l","year":"2012","journal-title":"J. Clin. Apher."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"26-38","DOI":"10.4037\/ccn2013555","article-title":"Supportive therapy for a patient with toxic epidermal necrolysis undergoing plasmapheresis.","volume":"33","author":"B Seczynska","year":"2013","journal-title":"Crit. Care Nurse."},{"key":"ref38","first-page":"436-439","article-title":"Ibuprofen-induced extensive toxic epidermal necrolysis - A multidisciplinary therapeutic approach in a single case.","volume":"12","author":"B Balint","year":"2014","journal-title":"Blood Transfus."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"768-777","DOI":"10.1111\/1346-8138.12925","article-title":"Efficacy of additional i.v. immunoglobulin to steroid therapy in Stevens-Johnson syndrome and toxic epidermal necrolysis.","volume":"42","author":"M Aihara","year":"2015","journal-title":"J. Dermatol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"877-879","DOI":"10.1016\/j.jdcr.2018.08.016","article-title":"Acute syndrome of pan-epidermolysis and thrombotic storm arising in a patient with systemic lupus erythematosus.","volume":"4","author":"E Burger","year":"2018","journal-title":"JAAD Case Rep."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"177-182","DOI":"10.1111\/ijd.13837","article-title":"Treatment of severe drug reactions by hemodialysis.","volume":"57","author":"R el-Azhary","year":"2018","journal-title":"Int. J. Dermatol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1-4","DOI":"10.1155\/2018\/2182604","article-title":"Successful Treatment of Methampyrone-Induced Toxic Epidermal Necrolysis with Therapeutic Plasma Exchange.","volume":"2018","author":"R Santosa","year":"2018","journal-title":"Case Rep. Med."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"217-221","DOI":"10.5114\/ada.2018.75247","article-title":"Toxic epidermal necrolysis in an 8-year-old girl successfully treated with cyclosporin a, intravenous immunoglobulin and plasma exchange.","volume":"35","author":"M Zieli\u0144ska","year":"2018","journal-title":"Postepy Dermatol. Alergol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e13442","DOI":"10.1111\/dth.13442","article-title":"Successful therapy of recurrent toxic epidermal necrolysis using total plasma exchange, continuous venovenous hemodiafiltration, and intravenous immunoglobulin\u2014Case report.","volume":"33","author":"A Krajewski","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"522-523","DOI":"10.18176\/jiaci.0692","article-title":"Covid-19 and ten treated with ivig and total plasma exchange: Simultaneous systemic treatment for both diseases.","volume":"31","author":"A Krajewski","year":"2021","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"465-472","DOI":"10.1177\/0961203320981128","article-title":"Toxic epidermal necrolysis after therapeutic plasma exchange in pediatric lupus patients and associated risk factors analysis.","volume":"30","author":"J Lu","year":"2021","journal-title":"Lupus."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1423-1427","DOI":"10.1111\/1346-8138.15963","article-title":"A pediatric case of Stevens-Johnson syndrome with acute liver failure, resulting in liver transplantation.","volume":"48","author":"M Totsuka","year":"2021","journal-title":"J. Dermatol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"229-234","DOI":"10.1016\/j.alit.2020.11.004","article-title":"Mortality and risk factors on admission in toxic epidermal necrolysis: A cohort study of 59 patients.","volume":"70","author":"T Watanabe","year":"2021","journal-title":"Allergol. Int."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1-4","DOI":"10.1155\/2022\/6128688","article-title":"Carbamazepine Induced Stevens-Johnson Syndrome That Developed into Toxic Epidermal Necrolysis: Review of the Literature.","volume":"2022","author":"Y Abuzneid","year":"2022","journal-title":"Case Rep Dermatol. Med."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"417-419","DOI":"10.1111\/cod.14038","article-title":"Toxic epidermal necrolysis during camrelizumab treatment for esophageal squamous cell carcinoma.","volume":"86","author":"Y Peng","year":"2022","journal-title":"Contact Dermatitis."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-995\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-995\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-995\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T12:05:51Z","timestamp":1682683551000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-995\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,5]]},"references-count":48,"URL":"https:\/\/doi.org\/10.12688\/f1000research.125050.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.137313.r156678","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.137313.r168692","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.137313.r168692","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.137313.r156678","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,5]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-995\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.137313.r156678, Talha Bin Emran, Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 05 Dec 2022, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/11-995\/v1#referee-response-156678","order":0,"name":"referee-response-156678","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.137313.r168692, Nurdjannah Jane Niode, Department of Dermatology and Venereology, Faculty of Medicine, Kandou General Hospital, Universitas Sam Ratulangi, Manado, 28 Apr 2023, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/11-995\/v1#referee-response-168692","order":1,"name":"referee-response-168692","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}