{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:06:17Z","timestamp":1772168777052,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.125115.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000}}],"reference-count":58,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background\u00a0<\/ns3:bold>\n                  <\/ns3:p>\n                  <ns3:p>In Covid-19 infection, the release of pro-inflammatory mediators in the setting of cytokine storm, primarily interleukin-6 (IL-6), has been hypothesized to induce pulmonary intravascular thrombosis and eventually systemic coagulopathy. However, the relationship between IL-6 and coagulopathy remains unclear in Covid-19 progression. We aimed to investigate the correlation of IL-6 with D-dimer, fibrinogen, prothrombin time (PT), and ferritin. Furthermore, we also analysed the changes of those parameters in relation with progression of Covid-19 disease.<\/ns3:p>\n                  <ns3:p\/>\n                  <ns3:p>\n                    <ns3:bold>Methods\u00a0<\/ns3:bold>\n                  <\/ns3:p>\n                  <ns3:p>A prospective cohort study was conducted in moderate and severe Covid-19 patients from June 2020 to January 2021. A serial evaluation of IL-6, D-dimer, fibrinogen, ferritin, and PT was performed and correlated with the patient's condition at admission and on the 14th day. The outcomes (improvement, worsening, or discharged patients) were recorded during the study.<\/ns3:p>\n                  <ns3:p\/>\n                  <ns3:p>\n                    <ns3:bold>Results\u00a0<\/ns3:bold>\n                  <\/ns3:p>\n                  <ns3:p>Of 374 patients, 73 study subjects (61 severe and 12 moderate Covid-19) were included in this study. A total of 35 out of 61 severe illness and one out of 12 moderate illness subjects had experienced worsening. Spearman-rank correlation of IL-6 with with ferritin, D-dimer, fibrinogen, and PT was 0.08 ( p=0.5), \u22120.13 ( p=0.27), 0.01 ( p=0.91), and 0.03 ( p=0.77), respectively. In ROC analysis, D-dimer (74,77%) and IL-6 (71,32%) were the highest among other variables (&gt;60%).<\/ns3:p>\n                  <ns3:p\/>\n                  <ns3:p>\n                    <ns3:bold>Conclusions\u00a0<\/ns3:bold>\n                  <\/ns3:p>\n                  <ns3:p>In Covid-19 patients, there was a correlation between elevated IL-6 and D-dimer levels with clinical deterioration. There was no correlation between elevated IL-6 levels with ferritin, D-dimer, fibrinogen, and PT levels. In conclusion, changes in IL-6 and D-dimer can be independent predictor of disease progression in moderate and severe Covid-19 patients.<\/ns3:p>","DOI":"10.12688\/f1000research.125115.2","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T11:55:09Z","timestamp":1695383709000},"page":"1285","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of IL-6, ferritin, and coagulopathy in Covid-19 clinical progression"],"prefix":"10.12688","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-5787","authenticated-orcid":false,"given":"Alvin 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