{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:00:00Z","timestamp":1791241200951,"version":"4.1.0"},"update-to":[{"DOI":"10.12688\/f1000research.126555.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000}}],"reference-count":16,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Healthium Medtech Limited"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Episiotomy procedure enlarges the vaginal outlet to facilitate childbirth. Polyglactin 910 fast-absorbing sutures are widely used for the repair of episiotomy because of their rapid absorption and less inflammatory response. This study was designed for subjective assessment of perineal pain post-episiotomy repair, with Trusynth Fast\n                    <ns4:sup>\u00ae<\/ns4:sup>\n                    and Vicryl Rapide\n                    <ns4:sup>\u00ae<\/ns4:sup>\n                    polyglactin 910 fast-absorbing sutures.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Method<\/ns4:bold>\n                    : This was a single-blind, randomized, prospective study conducted between January 7, 2021 and July 14, 2021 across two centers in India. Primiparous or multiparous women (18\u201440 years), who required episiotomy during vaginal delivery were included, and either Trusynth Fast\n                    <ns4:sup>\u00ae<\/ns4:sup>\n                    (n=47)\n                    <ns4:sup\/>\n                    or Vicryl Rapide\n                    <ns4:sup>\u00ae<\/ns4:sup>\n                    (n=49) suture was used for their episiotomy repair. The primary endpoint, perineal pain was assessed with visual analogue scale at all follow-up visits. The secondary endpoints, quantity of local anesthesia, number of sutures used, time to repair episiotomy, intraoperative suture handling, analgesics used, early and late wound complications, wound re-suturing, time to complete healing, presence of residual sutures, return to sexual activity, dyspareunia, and adverse events were also recorded.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results<\/ns4:bold>\n                    : The study showed no significant difference in perineal pain between the two groups at any visit. A statistically significant difference (p&lt;0.05) in total score of episiotomy healing scale on day 2 (0.13\u00b10.34\n                    <ns4:italic>versus<\/ns4:italic>\n                    0.35\u00b10.56) and swelling on day 2 (8.51\n                    <ns4:italic>versusversus<\/ns4:italic>\n                    28.57%) was noted between Trusynth Fast\n                    <ns4:sup>\u00ae<\/ns4:sup>\n                    and Vicryl Rapide\n                    <ns4:sup>\u00ae<\/ns4:sup>\n                    group. Non-significant difference was observed between the groups regarding anesthesia, number of sutures, time to repair episiotomy, intraoperative suture handling, analgesics, puerperal fever, wound infection, dehiscence, hematoma, urinary incontinence, re-suturing, time to complete healing, return to sexual activity and dyspareunia.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion<\/ns4:bold>\n                    : Trusynth Fast\n                    <ns4:sup>\u00ae<\/ns4:sup>\n                    suture is clinically equivalent to Vicryl Rapide\n                    <ns4:sup>\u00ae<\/ns4:sup>\n                    suture and can be used for episiotomy repair with minimal risk of perineal pain and wound complications.\n                  <\/ns4:p>\n                  <ns4:p>Clinical Trials Registry of India Registration: CTRI\/2020\/12\/029925; Registered on December 18, 2020<\/ns4:p>","DOI":"10.12688\/f1000research.126555.2","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T14:43:43Z","timestamp":1687531423000},"page":"1179","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical equivalence of Trusynth fast\u00ae and Vicryl rapide\u00ae polyglactin 910 fast absorbing sutures on maternal morbidity experienced by women following episiotomy repair: a single-blind, randomized study"],"prefix":"10.12688","volume":"11","author":[{"given":"Dongabanti","family":"Hemalatha Devi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4040-9049","authenticated-orcid":false,"given":"Chethana","family":"Bolanthakodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prema","family":"D\u2019Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudiki","family":"Bheema Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar Moharana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"TS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"474-480","DOI":"10.4103\/0971-5916.184304","article-title":"Pattern of episiotomy use & its immediate complications among vaginal deliveries in 18 tertiary care hospitals in India.","volume":"143","author":"S Singh","year":"2016","journal-title":"Indian J. Med. Res."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"96-101","DOI":"10.4103\/nmj.nmj_121_19","article-title":"Review of episiotomy and the effect of its risk factors on postepisiotomy complications at the University of Port Harcourt Teaching Hospital.","volume":"61","author":"C Ononuju","year":"2020","journal-title":"Niger Med. J."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1048-1070","DOI":"10.1007\/s10995-019-02732-5","article-title":"Birth-Related Perineal Trauma in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.","volume":"23","author":"M Aguiar","year":"2019","journal-title":"Matern. Child Health J."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"5107","DOI":"10.18203\/2320-1770.ijrcog20184976","article-title":"A comparative study of subcuticular and interrupted stitches for episiotomy.","volume":"7","author":"P Thukral","year":"2018","journal-title":"Int. J. Reprod. Contraception, Obstet. Gynecol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.18203\/2320-1770.ijrcog20172042","article-title":"Comparative study of episiotomy repair: absorbable synthetic versus chromic catgut suture material.","volume":"6","author":"D Perumal","year":"2017","journal-title":"Int. J. Reprod. Contraception, Obstet. Gynecol."},{"key":"ref6","first-page":"1-5","article-title":"Section: Obstetrics and Gynaecology \u201cA Comparative Study of Vicryl Rapide Versus Chromic Catgut for Episiotomy Repair\u201d.","volume":"8","author":"K Gupta","year":"2021"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"287-291","DOI":"10.33545\/gynae.2021.v5.i4e.1000","article-title":"A comparative study between fast absorbing polyglactin 910 vs chromic catgut in episiotomy wound repair.","volume":"5","author":"D Susmitha","year":"2021","journal-title":"Int. J. Clin. Obstet. 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Obstet. Gynecol."},{"key":"ref15","article-title":"Trusynth fast suture study [DATASET]. figshare.","author":"D Devi","year":"2022 cited 2022Sep22"},{"key":"ref16","article-title":"Trusynth fast study CONSORT checklist. figshare.","author":"D Devi","year":"2022 cited 2022Sep22"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-1179\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-1179\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-1179\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T09:15:18Z","timestamp":1687857318000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-1179\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,23]]},"references-count":16,"URL":"https:\/\/doi.org\/10.12688\/f1000research.126555.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.151757.r181233","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.151757.r181232","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.151757.r181233","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,23]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-1179\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.151757.r181233, Geetika Kaur, Wayne State University, Detroit, Michigan, 27 Jun 2023, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-1179\/v2#referee-response-181233","order":0,"name":"referee-response-181233","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.138979.r163358, Shraddha Shetty K, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal Academy of Higher Education, Mangaluru, Karnataka, 12 Jun 2023, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/11-1179\/v1#referee-response-163358","order":1,"name":"referee-response-163358","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The study is funded by Healthium Medtech Limited.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}