{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:34:15Z","timestamp":1780630455599,"version":"3.54.1"},"reference-count":55,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100003943","name":"The Mastocytosis Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100003943","id-type":"DOI","asserted-by":"crossref"}]},{"name":"F\u00f6rderclub Mastzellforschung eV"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>\n                      <ns4:italic>Background:<\/ns4:italic>\n                    <\/ns4:bold>\n                    \u00a0It has been shown repeatedly that mast cells can promote or prevent cancer development and growth. If development and\/or progression of a solid cancer is substantially influenced by mast cell activity, the frequencies of occurrence of solid cancers in patients with primary mast cells disorders would be expected to differ from the corresponding prevalence data in the general population. In fact, a recent study demonstrated that patients with systemic mastocytosis (i.e., a rare neoplastic variant of the primary mast cell activation disease) have increased risk for solid cancers, in particular melanoma and non-melanoma skin cancers. The aim of the present study is to examine whether the risk of solid cancer is increased in systemic mast cell activation syndrome (MCAS), the common systemic variant of mast cell activation disease.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>\n                      <ns4:italic>Methods:<\/ns4:italic>\n                    <\/ns4:bold>\n                    In the present descriptive study, we have analysed a large (n=828) patient group with MCAS, consisting of cohorts from Germany and the USA, for occurrence of solid forms of cancer and compared the frequencies of the different cancers with corresponding prevalence data for German and U.S. general populations.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>\n                      <ns4:italic>Results:<\/ns4:italic>\n                    <\/ns4:bold>\n                    Sixty-eight of the 828 MCAS patients (46 female, 22 male) had developed a solid tumor before the diagnosis of MCAS was made. Comparison of the frequencies of the malignancies in the MCAS patients with their prevalence in the general population revealed a significantly increased prevalence for melanoma and cancers of the breast, cervix uteri, ovary, lung, and thyroid in MCAS patients.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>\n                      <ns4:italic>Conclusions:<\/ns4:italic>\n                    <\/ns4:bold>\n                    Our data support the view that mast cells may promote development of certain malignant tumors. These findings indicate a need for increased surveillance of certain types of cancer in MCAS patients irrespective of its individual clinical presentation.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.12730.1","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T04:50:08Z","timestamp":1508993408000},"page":"1889","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Risk of solid cancer in patients with mast cell activation syndrome: Results from Germany and USA"],"prefix":"10.12688","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9005-2749","authenticated-orcid":false,"given":"Gerhard J.","family":"Molderings","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Zienkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Homann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Menzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence B.","family":"Afrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"190-201","DOI":"10.3109\/07853890.2016.1161231","article-title":"Often seen, rarely recognized: mast cell activation disease--a guide to diagnosis and therapeutic options.","volume":"48","author":"L Afrin","year":"2016","journal-title":"Ann Med."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1045-1053","DOI":"10.1080\/00365520701245744","article-title":"Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder.","volume":"42","author":"G Molderings","year":"2007","journal-title":"Scand J Gastroenterol."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"721-727","DOI":"10.1007\/s00251-010-0474-8","article-title":"Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects.","volume":"62","author":"G Molderings","year":"2010","journal-title":"Immunogenetics."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"e2266","DOI":"10.1371\/journal.pone.0002266","article-title":"Case-control cohort study of patients' perceptions of disability in mastocytosis.","volume":"3","author":"O Hermine","year":"2008","journal-title":"PLoS One."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"1099-104.e4","DOI":"10.1016\/j.jaci.2010.08.035","article-title":"Mast cell activation syndrome: proposed diagnostic criteria.","volume":"126","author":"C Akin","year":"2010","journal-title":"J Allergy Clin Immunol."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"197-205","DOI":"10.1111\/j.1365-2567.2012.03627.x","article-title":"Systemic mast cell activation disease: the role of molecular genetic alterations in pathogenesis, heritability and diagnostics.","volume":"137","author":"B Haenisch","year":"2012","journal-title":"Immunology."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"521-528","DOI":"10.1111\/bjh.12916","article-title":"Epidemiology of systemic mastocytosis in Denmark.","volume":"166","author":"S Cohen","year":"2014","journal-title":"Br J Haematol."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"1429-31.e1","DOI":"10.1016\/j.jaci.2012.10.015","article-title":"Prevalence of indolent systemic mastocytosis in a Dutch region.","volume":"131","author":"J van Doormaal","year":"2013","journal-title":"J Allergy Clin Immunol."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"e76241","DOI":"10.1371\/journal.pone.0076241","article-title":"Familial occurrence of systemic mast cell activation disease.","volume":"8","author":"G Molderings","year":"2013","journal-title":"PLoS One."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"420-425","DOI":"10.1046\/j.1365-2362.2003.01152.x","article-title":"Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma.","volume":"33","author":"D Ribatti","year":"2003","journal-title":"Eur J Clin Invest."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"666-674","DOI":"10.1016\/S0959-8049(02)00150-8","article-title":"Neovascularisation, expression of fibroblast growth factor-2, and mast cells with tryptase activity increase simultaneously with pathological progression in human malignant melanoma.","volume":"39","author":"D Ribatti","year":"2003","journal-title":"Eur J Cancer."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"955-960","DOI":"10.1053\/hupa.2000.16658","article-title":"Cutaneous malignant melanoma: correlation between neovascularization and peritumor accumulation of mast cells overexpressing vascular endothelial growth factor.","volume":"31","author":"R T\u00f3th-Jakatics","year":"2000","journal-title":"Hum Pathol."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"952-956","DOI":"10.1038\/sj.bjc.6603962","article-title":"Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer.","volume":"97","author":"N Nonomura","year":"2007","journal-title":"Br J Cancer."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"2257-2265","DOI":"10.1158\/1078-0432.CCR-09-1230","article-title":"Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression.","volume":"16","author":"M Strouch","year":"2010","journal-title":"Clin Cancer Res."},{"key":"ref-15","doi-asserted-by":"crossref","first-page":"940-944","DOI":"10.1136\/jcp.54.12.940","article-title":"The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagus.","volume":"54","author":"G Elpek","year":"2001","journal-title":"J Clin Pathol."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"195-199","DOI":"10.1034\/j.1600-0714.2003.00128.x","article-title":"Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma.","volume":"32","author":"A Iamaroon","year":"2003","journal-title":"J Oral Pathol Med."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"268-273","DOI":"10.1111\/j.1600-0714.2004.00297.x","article-title":"Characterization of mast cell subpopulations in lip cancer.","volume":"34","author":"I Rojas","year":"2005","journal-title":"J Oral Pathol Med."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"27-30","DOI":"10.1097\/DAD.0b013e31815c932a","article-title":"Mast cells have prognostic value in Merkel cell carcinoma.","volume":"30","author":"T Beer","year":"2008","journal-title":"Am J Dermatopathol."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"103-108","DOI":"10.1016\/S0169-5002(99)00076-8","article-title":"Correlation between mast cells and survival rates in patients with pulmonary adenocarcinoma.","volume":"26","author":"M Tomita","year":"1999","journal-title":"Lung Cancer."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"8959-8967","DOI":"10.1200\/JCO.2005.01.4910","article-title":"Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer.","volume":"23","author":"T Welsh","year":"2005","journal-title":"J Clin Oncol."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"697-705","DOI":"10.1016\/j.humpath.2009.04.029","article-title":"Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance.","volume":"41","author":"M Carlini","year":"2010","journal-title":"Hum Pathol."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"1087-1093","DOI":"10.1034\/j.1399-3003.2000.01517.x","article-title":"Mast cells correlate with angiogenesis and poor outcome in stage I lung adenocarcinoma.","volume":"15","author":"A Imada","year":"2000","journal-title":"Eur Respir J."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"2686-2692","DOI":"10.1002\/1097-0142(20000615)88:12<2686::AID-CNCR6>3.0.CO;2-6","article-title":"Mast cell density is associated with angiogenesis and poor prognosis in pulmonary adenocarcinoma.","volume":"88","author":"I Takanami","year":"2000","journal-title":"Cancer."},{"key":"ref-24","first-page":"785-788","article-title":"Mast cells in breast cancer.","volume":"13","author":"S Aaltomaa","year":"1993","journal-title":"Anticancer Res."},{"key":"ref-25","doi-asserted-by":"publisher","first-page":"690-695","DOI":"10.1038\/modpathol.3800094","article-title":"The presence of stromal mast cells identifies a subset of invasive breast cancers with a favorable prognosis.","volume":"17","author":"S Dabiri","year":"2004","journal-title":"Mod Pathol."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"249-257","DOI":"10.1007\/s10549-007-9546-3","article-title":"Stromal mast cells in invasive breast cancer are a marker of favourable prognosis: a study of 4,444 cases.","volume":"107","author":"A Rajput","year":"2008","journal-title":"Breast Cancer Res Treat."},{"key":"ref-27","first-page":"2465-2471","article-title":"Mast cells in invasive ductal breast cancer: different behavior in high and minimum hormone-receptive cancers.","volume":"27","author":"F della Rovere","year":"2007","journal-title":"Anticancer Res."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"615-619","DOI":"10.3892\/or_00000676","article-title":"Mast cell tryptase promotes breast cancer migration and invasion.","volume":"23","author":"M Xiang","year":"2010","journal-title":"Oncol Rep."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"837-842","DOI":"10.1111\/j.1365-2559.2007.02869.x","article-title":"Angiogenesis and mast cells in human breast cancer sentinel lymph nodes with and without micrometastases.","volume":"51","author":"D Ribatti","year":"2007","journal-title":"Histopathology."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"487-495","DOI":"10.1002\/(SICI)1096-9896(199912)189:4<487::AID-PATH484>3.0.CO;2-I","article-title":"Independent prognostic value of eosinophil and mast cell infiltration in colorectal cancer tissue.","volume":"189","author":"H Nielsen","year":"1999","journal-title":"J Pathol."},{"key":"ref-31","doi-asserted-by":"publisher","first-page":"1210-1214","DOI":"10.3748\/wjg.v11.i8.1210","article-title":"Prognostic significance of cell infiltrations of immunosurveillance in colorectal cancer.","volume":"11","author":"S Tan","year":"2005","journal-title":"World J Gastroenterol."},{"key":"ref-32","first-page":"723-732","article-title":"Prognostic significance of microvessel density and mast cell density for the survival of Thai patients with primary colorectal cancer.","volume":"91","author":"S Yodavudh","year":"2008","journal-title":"J Med Assoc Thai."},{"key":"ref-33","doi-asserted-by":"publisher","first-page":"110-118","DOI":"10.5146\/tjpath.2012.01109","article-title":"The relationship between the stromal mast cell number, microvessel density, c-erbB-2 staining and survival and prognostic factors in colorectal carcinoma.","volume":"28","author":"B Elezo\u011flu","year":"2012","journal-title":"Turk Patoloji Derg."},{"key":"ref-34","doi-asserted-by":"publisher","first-page":"162-169","DOI":"10.1016\/j.dld.2004.09.028","article-title":"Tumour angiogenesis and mast cell density in the prognostic assessment of colorectal carcinomas.","volume":"37","author":"M Acikalin","year":"2005","journal-title":"Dig Liver Dis."},{"key":"ref-35","doi-asserted-by":"publisher","first-page":"1265-1275","DOI":"10.1111\/j.1440-1746.2007.05009.x","article-title":"Prognostic significance of mast cell number and microvascular density for the survival of patients with primary colorectal cancer.","volume":"24","author":"M Gulubova","year":"2009","journal-title":"J Gastroenterol Hepatol."},{"key":"ref-36","doi-asserted-by":"publisher","first-page":"159-163","DOI":"10.1016\/0046-8177(89)90180-9","article-title":"Prognostic significance of eosinophils and mast cells in rectal cancer: findings from the National Surgical Adjuvant Breast and Bowel Project (protocol R-01).","volume":"20","author":"E Fisher","year":"1989","journal-title":"Hum Pathol."},{"key":"ref-37","doi-asserted-by":"publisher","first-page":"1031-1041","DOI":"10.2353\/ajpath.2010.100070","article-title":"Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy.","volume":"177","author":"A Johansson","year":"2010","journal-title":"Am J Pathol."},{"key":"ref-38","doi-asserted-by":"publisher","first-page":"1069-1075","DOI":"10.1002\/ajh.24490","article-title":"Risk of solid cancer, cardiovascular disease, anaphylaxis, osteoporosis and fractures in patients with systemic mastocytosis: A nationwide population-based study.","volume":"91","author":"S Broesby-Olsen","year":"2016","journal-title":"Am J Hematol."},{"key":"ref-39","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1756-8722-4-10","article-title":"Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options.","volume":"4","author":"G Molderings","year":"2011","journal-title":"J Hematol Oncol."},{"key":"ref-40","article-title":"Verbreitung von Krebserkrankungen in Deutschland. Entwicklung der Pr\u00e4valenzen zwischen 1990 und 2010. Beitr\u00e4ge zur Gesundheitsberichterstattung des Bundes."},{"key":"ref-41","article-title":"SEER Cancer Statistics Review, 1975\u20132013","author":"N Howlader","year":"2016"},{"key":"ref-42","doi-asserted-by":"publisher","first-page":"279-282","DOI":"10.1001\/archdermatol.2010.4","article-title":"Prevalence of a history of skin cancer in 2007: results of an incidence-based model.","volume":"146","author":"R Stern","year":"2010","journal-title":"Arch Dermatol."},{"key":"ref-43","doi-asserted-by":"publisher","first-page":"583-584","DOI":"10.2340\/00015555-1788","article-title":"Increased risk of malignant melanoma in patients with systemic mastocytosis?","volume":"94","author":"H H\u00e4gglund","year":"2014","journal-title":"Acta Derm Venereol."},{"key":"ref-44","doi-asserted-by":"publisher","first-page":"455-457","DOI":"10.1111\/j.1365-2230.1991.tb01235.x","article-title":"Malignant melanoma and systemic mastocytosis--a possible association?","volume":"16","author":"P Todd","year":"1991","journal-title":"Clin Exp Dermatol."},{"key":"ref-45","first-page":"112-119","article-title":"Mast Cell Disorders, Melanoma and Pancreatic Carcinoma: From a Clinical Observation to a Brief Review of the Literature.","volume":"25","author":"G Paolino","year":"2017","journal-title":"Acta Dermatovenerol Croat."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"337-338","DOI":"10.1038\/jid.2014.417","article-title":"KIT in melanoma: many shades of gray.","volume":"135","author":"A Slipicevic","year":"2015","journal-title":"J Invest Dermatol."},{"key":"ref-47","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2016-1127","article-title":"KIT\/D816V induces SRC-mediated tyrosine phosphorylation of MITF and altered transcription program in melanoma","volume":"76","author":"B Phung","year":"2016"},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"339-362","DOI":"10.1086\/592850","article-title":"Allergies: their role in cancer prevention.","volume":"83","author":"P Sherman","year":"2008","journal-title":"Q Rev Biol."},{"key":"ref-49","doi-asserted-by":"publisher","first-page":"1838-1841","DOI":"10.1016\/S0959-8049(99)00209-9","article-title":"Allergy and other selected diseases and risk of colorectal cancer.","volume":"35","author":"E Negri","year":"1999","journal-title":"Eur J Cancer."},{"key":"ref-50","first-page":"8910-8920","article-title":"Possible biological and translational significance of mast cells density in colorectal cancer.","volume":"20","author":"I Marech","year":"2014","journal-title":"World J Gastroenterol."},{"key":"ref-51","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7755.DISP15-C73","article-title":"A relationship between mast cells and the racial disparity of prostate cancer.","volume":"25","author":"H Hempel","year":"2016","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"ref-52","first-page":"365-368","article-title":"Solid and hematologic malignancies in 60 patients with systemic mast cell disease.","volume":"113","author":"W Travis","year":"1989","journal-title":"Arch Pathol Lab Med."},{"key":"ref-53","first-page":"129-131","article-title":"Improved metastatic uterine papillary serous cancer outcome with treatment of mast cell activation syndrome.","volume":"28","author":"L Afrin","year":"2014","journal-title":"Oncology (Williston Park)."},{"key":"ref-54","doi-asserted-by":"publisher","first-page":"5812-5817","DOI":"10.1182\/blood-2010-08-292144","article-title":"How I treat patients with advanced systemic mastocytosis.","volume":"116","author":"P Valent","year":"2010","journal-title":"Blood."},{"key":"ref-55","doi-asserted-by":"publisher","DOI":"10.5256\/f1000research.12730.d181450","article-title":"Dataset 1 in: Risk of solid cancer in patients with mast cell activation syndrome: Results from Germany and USA.","author":"G Molderings","year":"2017","journal-title":"F1000Research."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/6-1889\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/6-1889\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/6-1889\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T07:51:24Z","timestamp":1544082684000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/6-1889\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,26]]},"references-count":55,"URL":"https:\/\/doi.org\/10.12688\/f1000research.12730.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.13790.r27327","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.13790.r28307","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.13790.r28307","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.13790.r27327","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,26]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/6-1889\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.13790.r27327, Bastian Walz, medius Klinik Kirchheim, Vaskulitiszentrum S\u00fcd, Klinik f\u00fcr Innere Medizin, Rheumatologie und Immunologie, Kirchheim-Teck, Germany, 21 Nov 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-1889\/v1#referee-response-27327","order":0,"name":"referee-response-27327","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.13790.r28307, Leonard Weinstock, Specialists in Gastroenterology, LLC, Washington University School of Medicine, St. Louis, MO, USA, 30 Nov 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/6-1889\/v1#referee-response-28307","order":1,"name":"referee-response-28307","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Publication was supported by the F\u00f6rderclub Mastzellforschung e.V., Germany. Collection of the U.S. data was supported by The Mastocytosis Society. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}