{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:14Z","timestamp":1772168834315,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.127367.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000}}],"reference-count":22,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Hemithyroidectomy is one of the most common procedures performed. It is used to treat patients with benign unilateral nodules. Hemithyroidectomy results in fewer risks of hypothyroidism and the need for thyroid hormone replacement therapy. The present study was designed to identify potential clinicopathologic risk factors associated with the onset of biochemical hypothyroidism.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    We conducted a retrospective review of all patients who underwent hemithyroidectomy between 2004 and 2019. Hypothyroidism was defined as a serum thyrotropin level greater than 5 mIU\/L. The patients were analyzed for age, sex, preoperative and postoperative thyroid stimulating hormone (TSH), state, side, and volume of the remaining lobe, and histologic diagnosis.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    Hypothyroidism was diagnosed in 30.8% of 214 patients. This complication appeared in the first year in 83.3% of the cases. A preoperative TSH level greater than 1.32 mIU\/l, a remaining volume of the lobe less than 3 ml, and the presence of thyroiditis were associated with a significant increase in the risk of developing hypothyroidism (p&lt;0.01). There were no significant differences in age, sex, state, and side of the remaining lobe. The mean thyroxine dose was 57 \u00b1 26 micrograms.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    The risk of hypothyroidism after hemithyroidectomy should be assessed prior to surgery. Close monitoring is recommended in patients at high risk of developing this complication. However, all patients who undergo hemithyroidectomy should be monitored at least for the first year.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.127367.2","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T10:30:11Z","timestamp":1671618611000},"page":"1355","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictive factors for hypothyroidy after hemithyroidectomy"],"prefix":"10.12688","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0880-1032","authenticated-orcid":false,"given":"Mohamed Amine","family":"Chaabouni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2409-3996","authenticated-orcid":false,"given":"Moncef","family":"Sellami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esma","family":"Jameleddine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania","family":"Kharrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-989X","authenticated-orcid":false,"given":"Wadii","family":"Thabet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3027-1755","authenticated-orcid":false,"given":"Malek","family":"Mnejja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7344-0627","authenticated-orcid":false,"given":"Boutheina","family":"Hammami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirine","family":"Ayadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imen","family":"Achour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilhem","family":"Charfeddine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"6-17","DOI":"10.1159\/000345498","article-title":"Hemithyroidectomy: a meta-analysis of postoperative need for hormone replacement and complications.","volume":"75","author":"E Kandil","year":"2013","journal-title":"ORL J. Otorhinolaryngol Relat. Spec."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1463-1467","DOI":"10.1002\/hed.25592","article-title":"Predictors of thyroxine replacement following hemithyroidectomy in a south east Asian cohort.","volume":"41","author":"P Ng","year":"2019","journal-title":"Head Neck."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"380-386","DOI":"10.4174\/jkss.2011.81.6.380","article-title":"Is it possible to predict hypothyroidism after thyroid lobectomy through thyrotropin, thyroglobulin, anti-thyroglobulin, and anti-microsomal antibody?","volume":"81","author":"J Cho","year":"2011","journal-title":"J. Korean Surg. Soc."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"313971","DOI":"10.1155\/2015\/313971","article-title":"Prospective Analysis of Risk for Hypothyroidism after Hemithyroidectomy.","volume":"2015","author":"V Beisa","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1429-1436","DOI":"10.1210\/jc.2015-3997","article-title":"Hypothyroidism Following Hemithyroidectomy: Incidence, Risk Factors, and Clinical Characteristics.","volume":"101","author":"D Ahn","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"957-962","DOI":"10.1016\/j.asjsur.2019.01.015","article-title":"Post-hemithyroidectomy hypothyroidism in non autoimmune thyroiditis patients: Incidence, risk factors and duration of follow up.","volume":"42","author":"S Chong","year":"2019","journal-title":"Asian J. Surg."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2243-2255","DOI":"10.1210\/jc.2012-1063","article-title":"Risk of Hypothyroidism following Hemithyroidectomy: Systematic Review and Meta-Analysis of Prognostic studies.","volume":"97","author":"H Verloop","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2839-2844","DOI":"10.1007\/s00268-013-2201-8","article-title":"Hypothyroidism after hemithyroidectomy.","volume":"37","author":"M Said","year":"2013","journal-title":"World J. Surg."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"243-255","DOI":"10.1007\/s12020-020-02410-5","article-title":"Prevalence of and risk factors for hypothyroidism after hemithyroidectomy: a systematic review and meta-analysis.","volume":"70","author":"Z Li","year":"2020","journal-title":"Endocrine."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1317-1324","DOI":"10.1210\/jc.2016-3597","article-title":"Clinical Features of Early and Late Postoperative Hypothyroidism After Lobectomy.","volume":"102","author":"S Park","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"461-466","DOI":"10.1016\/j.amjsurg.2011.03.004","article-title":"Clinicopathologic predictors for early and late biochemical hypothyroidism after hemithyroidectomy.","volume":"203","author":"K Chu","year":"2012","journal-title":"Am. J. Surg."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"4405-4413","DOI":"10.1245\/s10434-019-07786-x","article-title":"Levothyroxine Supplementation Following Hemithyroidectomy: Incidence, Risk Factors, and Characteristics.","volume":"26","author":"D Ahn","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"453-457","DOI":"10.1007\/s00405-007-0513-8","article-title":"Prediction of hypothyroidism after hemithyroidectomy: a biochemical and pathological analysis.","volume":"265","author":"Y Koh","year":"2008","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2548-2554","DOI":"10.1245\/s10434-011-1627-1","article-title":"Detection and management of hypothyroidism following thyroid lobectomy: evaluation of a clinical algorithm.","volume":"18","author":"A Johner","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"273-278","DOI":"10.1016\/j.jss.2014.07.003","article-title":"Prediction of thyroid hormone supplementation after thyroid lobectomy.","volume":"193","author":"D Lee","year":"2015 Jan","journal-title":"J. Surg. Res."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1525-1532","DOI":"10.1245\/s10434-016-5743-9","article-title":"Effect of Thyroid Remnant Volume on the Risk of Hypothyroidism After Hemithyroidectomy: A Prospective Study.","volume":"24","author":"B Lang","year":"2017","journal-title":"Ann. Surg. Oncol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3819-3823","DOI":"10.1177\/0300060518781228","article-title":"Prevalence of hypothyroidism among patients with isthmus-preserved thyroid lobectomy.","volume":"46","author":"A Salih","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"68-71","DOI":"10.1159\/000323007","article-title":"Subclinical hypothyroidism following hemithyroidectomy: a simple risk-scoring system using age and preoperative thyrotropin level.","volume":"73","author":"C Tomoda","year":"2011","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"45-48","DOI":"10.4103\/1658-631X.194243","article-title":"Risk Factors of Post-Hemithyroidectomy Hypothyroidism.","volume":"5","author":"A Al-Shalhoub","year":"2017","journal-title":"Saudi J. Med. Med. Sci."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1011-1018","DOI":"10.1177\/0194599820962486","article-title":"Hormonal Outcomes Following Hemithyroidectomy.","volume":"164","author":"L Buehler","year":"2021","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"295-299","DOI":"10.1177\/014556130708600517","article-title":"Hypothyroidism following hemithyroidectomy for benign nontoxic thyroid disease.","volume":"86","author":"K Seiberling","year":"2007","journal-title":"Ear Nose Throat J."},{"key":"ref21","doi-asserted-by":"publisher","author":"M Sellami","year":"2022","DOI":"10.6084\/m9.figshare.21404862.v1"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/11-1355\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-1355\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/11-1355\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T15:25:20Z","timestamp":1718724320000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/11-1355\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":22,"URL":"https:\/\/doi.org\/10.12688\/f1000research.127367.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.127367.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.142052.r158506","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.142052.r158507","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.142052.r158507","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.142052.r158506","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,21]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/11-1355\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.142052.r158506, Ingrid Breuskin, Department of Head and Neck Oncology, Gustave Roussy Institute, University Paris Saclay, Villejuif, 21 Dec 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-1355\/v2#referee-response-158506","order":0,"name":"referee-response-158506","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.142052.r158507, Senda Turki, Universit\u00e9 Tunis El Manar, Tunis, 03 Jan 2023, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/11-1355\/v2#referee-response-158507","order":1,"name":"referee-response-158507","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}