{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:57:54Z","timestamp":1788519474535,"version":"build-2803163510"},"update-to":[{"DOI":"10.12688\/f1000research.12904.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000}}],"reference-count":56,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001607","name":"Eye and Ear Foundation of Pittsburgh","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001607","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background<\/ns4:bold>\n                    : To determine the predictive value of postoperative bleb morphological features and intraocular pressure (IOP) on the success rate of trabeculectomy.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods<\/ns4:bold>\n                    : In this prospective interventional case series, we analyzed for one year 80 consecutive primary open angle glaucoma patients who underwent mitomycin-augmented trabeculectomy. Bleb morphology was scored using the Indiana bleb appearance grading scale (IBAGS). Success was defined as IOP \u226415 mmHg at 12 months. We applied a multivariable regression analysis and determined the area under the receiver operating characteristic curve (AUC).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results<\/ns4:bold>\n                    : The mean age of participants was 62\u00b112.3 years in the success and 63.2\u00b116.3 years in the failure group (P= 0.430) with equal gender distribution (P=0.911). IOPs on day 1, 7 and 30 were similar in both (P= 0.193, 0.639, and 0.238, respectively.) The AUC of IOP at day 1, day 7 and 30 for predicting a successful outcome was 0.355, 0.452, and 0.80, respectively. The AUC for bleb morphology parameters of bleb height, extension, and vascularization, on day 14 were 0.368, 0.408, and 0.549, respectively. Values for day 30 were 0.428, 0.563, and 0.654. IOP change from day 1 to day 30 was a good predictor of failure (AUC=0.838, 95% CI: 0.704 to 0.971) with a change of more than 3 mmHg predicting failure with a sensitivity of 82.5% (95% CI: 68 to 91%) and a specificity of 87.5% (95% CI: 53 to 98%).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions<\/ns4:bold>\n                    : IOP on day 30 had a fair to good accuracy while bleb features failed to predict success except bleb vascularity that had a poor to fair accuracy.\u00a0 An IOP increase more than 3 mmHg during the first 30 days was a good predictor of failure.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.12904.2","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T06:15:06Z","timestamp":1513664106000},"page":"1898","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Predictive value of early postoperative IOP and bleb morphology in Mitomycin-C augmented trabeculectomy"],"prefix":"10.12688","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7301-7047","authenticated-orcid":false,"given":"Hamed","family":"Esfandiari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Pakravan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-1213","authenticated-orcid":false,"given":"Nils A.","family":"Loewen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Yaseri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"2265-2270.e1","DOI":"10.1016\/j.ophtha.2007.02.005","article-title":"Utilization of various glaucoma surgeries and procedures in Medicare beneficiaries from 1995 to 2004.","volume":"114","author":"P Ramulu","year":"2007","journal-title":"Ophthalmology."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1615-24","DOI":"10.1016\/j.ophtha.2015.04.015","article-title":"Use of Various Glaucoma Surgeries and Procedures in Medicare Beneficiaries from 1994 to 2012.","volume":"122","author":"K Arora","year":"2015","journal-title":"Ophthalmology."},{"key":"ref-3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01815-z","article-title":"Rapid learning curve assessment in an ex vivo training system for microincisional glaucoma surgery.","volume":"7","author":"Y Dang","year":"2017","journal-title":"Sci Rep."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"67","DOI":"10.12688\/f1000research.10236.2","article-title":"Training strategies and outcomes of ab interno trabeculectomy with the trabectome [version 2; 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Esfandiari","year":"2017","journal-title":"F1000Research."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/6-1898\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/6-1898\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/6-1898\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T07:17:06Z","timestamp":1544080626000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/6-1898\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,19]]},"references-count":56,"URL":"https:\/\/doi.org\/10.12688\/f1000research.12904.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.14499.r29149","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.14499.r29149","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,19]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/6-1898\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.13988.r27402, Ding Lin, Aier School of Ophthalmology, Changsha Aier Eye Hospital, Changsha, China, 08 Nov 2017, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/6-1898\/v1#referee-response-27402","order":0,"name":"referee-response-27402","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Nils Loewen<\/b>; \n<i>Posted: 01 Dec 2017<\/i>; \n<b>1. <\/b>There are mistakes in the study results and we listed some examples in the following and you should revised it in your paper carefully and discreetly. \n<b>1.1<\/b> In the article, they describe that collect IOP outcomes on Day 7, but it was Week 2 in table 2. In the results part of&nbsp;Line 3 Page 1 (All P\u22650.2), but it was 0.193 in day 1 in table 2. \n<b>&nbsp; &nbsp; &nbsp;Authors: <\/b>We very much appreciate taking the time and effort to assess our manuscript. We are grateful for the many good suggestions. There was indeed a discrepancy in the Results section. It should be week 1 in the table as we now write correctly. We have confirmed this in our source SPSS database file.  Regarding the P values in the abstract, we replaced &gt;0.2 in the sentence:&nbsp; \u201cIOP&nbsp;of&nbsp;patients&nbsp;with&nbsp;a&nbsp;successful&nbsp;outcome&nbsp;did&nbsp;not&nbsp;differ&nbsp;from&nbsp;unsuccessful&nbsp;ones on&nbsp;day&nbsp;1,&nbsp;7&nbsp;and&nbsp;30&nbsp;(all&nbsp;P\u22650.2).\u201c with specific P values for each time point: \u201cIOP&nbsp;of&nbsp;patients&nbsp;with&nbsp;a&nbsp;successful&nbsp;outcome&nbsp;did&nbsp;not&nbsp;differ&nbsp;from&nbsp;unsuccessful&nbsp;ones on&nbsp;day&nbsp;1,&nbsp;7&nbsp;and&nbsp;30&nbsp;(P= 0.193, 0.639, and 0.238, respectively.)\u201d  \n<b>1.2 <\/b>&nbsp;IOP change more than 3mmHg in Page 1, but it was less than or equal than 3 mmHg in Page 6. \n<b>&nbsp; &nbsp; &nbsp; Authors: <\/b>That is correct but there is no real contradiction. The reason for this is that we talk about that a change in IOP less than or equal to 3 can predict the \n<i><u>success<\/u><\/i> at month 12. In contrast, we talk about \n<i><u>failure<\/u><\/i> when a change of more than 3 mmHg was observed.  \n<b>2. <\/b>There are some misunderstanding in the article. \n<b>2.1<\/b> The first sentence in the results of page 1. (Age and gender were equally distributed (62.3&plusmn;13.1 years, P=0.911).) \n<b>&nbsp; &nbsp; &nbsp;&nbsp;Authors:<\/b> Thank you for pointing this out. We changed the sentence &quot;Age and gender were equally distributed&quot; to &quot;The mean age of the study participants was 62&plusmn;12.3 years in the success and 63.2&plusmn;16.3 years in the failure group (P= 0.430) with equal gender distribution (P=0.911)&quot;.  \n<b>2.2 <\/b>The anterior chamber was formed by injection of BSS a paracentesis, and the filtration was titrated by adjusting the tension of the scleral flap sutures. \n<b>&nbsp; &nbsp; &nbsp; Authors:<\/b> We apologize and have changed the sentence to state \u201cThe anterior chamber was formed by injection of BSS a paracentesis, and the filtration was titrated by adjusting the tension of the scleral flap sutures \u201cto \u201cThe anterior chamber was formed by injection of BSS through a sideport, and the filtration was titrated by adjusting the tension of the scleral flap sutures&quot;. &nbsp;&nbsp;  \n<b>3. <\/b>The releasable sutures were removed as needed after 72 hours depending on bleb appearance to achieve IOPs near 10 mmHg. (Page 3, Marked in yellow and underline).&nbsp;In what time the releasable suture were removed for most of them (for example 7-10 days or something else for 70%(or ?%) patient), and you removed the two releasable suture for one time or two time respectively. If you removed the suture for two times, how much time will pass between them. \n<b>&nbsp; &nbsp; &nbsp; Authors:<\/b> We changed Methods to state: &quot;In most cases, the releasable sutures were removed within 4 weeks after the surgery. One removed first and if the IOP was not within the target range the other one was released during at the follow up one week later. Needling was done during the postoperative period for impending failure from highly vascularized and contracting blebs&quot;.","URL":"https:\/\/f1000research.com\/articles\/6-1898\/v2#referee-comment-3221","order":1,"name":"referee-comment-3221","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.14499.r29149, Frances Meier-Gibbons, Eye Center Rapperswil, Rapperswil, Switzerland, 27 Dec 2017, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/6-1898\/v2#referee-response-29149","order":2,"name":"referee-response-29149","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study was funded in part by the Initiative to Cure Glaucoma, of the Eye and Ear Foundation of Pittsburgh, and by the Ophthalmic Research Center of the Shahid Beheshti University of Medical Sciences, and by unrestricted grant from Research to Prevent Blindness, New York, NY. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}