{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:06:23Z","timestamp":1772168783160,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.129891.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000}},{"DOI":"10.12688\/f1000research.129891.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000}},{"DOI":"10.12688\/f1000research.129891.3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000}}],"reference-count":67,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Background Removal of the microbial deposits (plaque and calculus) by performing effective scaling and root planing (SRP) is the fundamental step for managing periodontal disease (gingivitis and periodontitis). Various adjuncts in the form of mouthwash, gels, and toothpaste are also being used as adjuncts to SRP for managing periodontitis. Recently,\n                    <ns3:italic>Lycium barbarum<\/ns3:italic>\n                    (\n                    <ns3:italic>L. barbarum<\/ns3:italic>\n                    ), commonly known as goji berry or wolfberry, has gained popularity for managing chronic inflammatory and infectious diseases. However, its efficacy in managing periodontitis has never been explored. Hence the present study aims to evaluate the efficacy of goji berry mouthwash compared to chlorhexidine mouthwash for managing periodontitis. Methods 60 adult participants were divided randomly using computer-generated random sequences into two groups (case group:\n                    <ns3:italic>L. barbarum<\/ns3:italic>\n                    mouthwash (Males: 16; Female: 14); control group: 0.2% chlorhexidine gluconate mouthwash (Males: 14; Females: 16)). The changes in the gingival index (Gi), plaque index (Pi), bleeding on probing (BOP), clinical attachment loss (CAL), probing pocket depth (PPD), microbial load, and antioxidant levels (protein thiol) in saliva were noted at the baseline, at 15 days and one month. Results A significant reduction in the mean PPD, Pi, BOP, and Gi was seen from baseline to one month in both the control (P-value=0.006, 0.027, 0.000, and 0.036 respectively) and test groups (P-value=0.035, 0.000, 0.034, and 0.000 respectively). However, the antioxidant levels (protein thiol) in saliva were significantly increased only in the test group. Conclusion Goji berry mouthwash along with SRP reduced the Gi, Pi, BOP, and PPD in patients with periodontitis. However, no statistically significant difference was noted between the use of goji berry and chlorhexidine mouthwash. Goji berry mouthwash was more effective than chlorhexidine in increasing the antioxidant levels in saliva.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.129891.4","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T12:25:08Z","timestamp":1732623908000},"page":"302","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Lycium barbarum (Goji berry) mouthwash for managing periodontitis: a randomized clinical trial"],"prefix":"10.12688","volume":"12","author":[{"given":"Amee","family":"Sanghavi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laasya","family":"Shettigar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4805-5943","authenticated-orcid":false,"given":"Aditi","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashmeet","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-1108","authenticated-orcid":false,"given":"Richard","family":"Lobo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6781-5579","authenticated-orcid":false,"given":"Padmaja A","family":"Shenoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShivaPrasada","family":"Gadag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1995-3114","authenticated-orcid":false,"given":"Usha Y","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mangalore","family":"Shravya S","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shobha Ullas","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prajna P","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"32-37","DOI":"10.1902\/annals.1999.4.1.32","article-title":"Periodontitis.","volume":"4","author":"T Flemmig","year":"1999","journal-title":"Ann. 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Sharma, Deepti Anand, Department of Periodontics and Oral Implantology, Postgraduate Institute of Dental Sciences, Rohtak, Haryana, 06 Jun 2023, version 1, 1 approved with reservations, 1 not approved","URL":"https:\/\/f1000research.com\/articles\/12-302\/v1#referee-response-173857","order":0,"name":"referee-response-173857","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Aditi Chopra<\/b>; \n<i>Posted: 06 Nov 2023<\/i>; Firstly, we would like to thank all the reviewers and the editor for spending their valuable time and providing us with their valuable comments and suggestions. We truly appreciate your guidance in improving our work. We have tried to address the comments and revised the manuscript accordingly. The changes in the manuscript have been highlighted in track change mode in the revised manuscript.  Reviewer 1  Abstract: In the abstract, results have been mentioned as significant in both the groups, however the p values mentioned don't corroborate the significant results. Please do the necessary corrections.  Response: We thank the reviewers for their valuable insight. We have now revised the abstract and interpretation of the results. &nbsp;  Introduction: It needs to be brief &amp; relevant. The objectives of the study may be omitted in the introduction.  Response: We thank the reviewer for their suggestion. We have now revised and shortened the introduction\/background section in the abstract. &nbsp;  Methodology: Please describe in detail the method of randomization of 57 participants in test group(30) and control group(27). Were the participants recruited on consecutive order or in pooled manner?  Response: We have now added the method of randomization (computer-generated random sequence) in the abstract. The participants were recruited in as when they come to the OPD and randomized once the consequent order. &nbsp;  Out of 30 participants in test group, 15 were dropped out, only 15 were included in the statistical analysis. The sample size calculation was 27 patients in each group. The rationale of sample size calculation is not served in this study. 'Around' 60 participants were recruited; Please avoid vague terms like 'around'. Please mention 57.  Response: We thank the reviewer for their valuable suggestion. We have now revised paper accordingly and removed the word around along number of participants &nbsp;  Out of 27 allocated to control group, 16 were lost to follow up hence only 11 are left for follow up completion, however in the flow chart it is mentioned, 14 participants were analyzed. Please look into it.  Response: We thank the reviewer for their valuable suggestion. We have now revised paper accordingly and provided the corrected CONSORT flow diagram  Results  In the result section, demographic data is with reference to patients recruited whereas all other data is with reference to patients who completed the study. Similar data may be included in the result section, either all of the patients recruited or only the patients who have completed the follow up.  Response: We thank the reviewer for their valuable suggestion. We have now revised paper accordingly and included the data related to the patients who were recruited &nbsp;  All the results have been presented in overall average values. PPD is an important parameter influencing the outcomes of periodontal intervention. Data needs to be segregated as per PPD.  Response: We thank the reviewers for their valuable insight. However, since it study was conducted on a small number of participant where segregation of PPD was not possible due to similarity in the amount of PPD, we have mentioned the data as combine reduction in PPD from baseline, moreover with segregation we found that all the patient fall under 1-3 mm of PPD and CAL loss due to recession of 1-2 mm .  Discussion:  Please focus the discussion on the results of the overall study period of one month, unless there is some interesting finding otherwise. It takes 6-8 weeks for healing to complete after SRP, Results of SRP are required to be estimated after this period. However, the follow-up of study period was one month; Please comment on it.  Response: We thank the reviewer for the critical appraisal of these key findings. We have now added these points to the limitations of the study. We have kept the follow-up at 1 month as long-term use of chlorhexidine mouthwash is not recommended owing to the development of various side effects &nbsp;  A significant part of discussion is only review of literature with reference to Goji berry; Please avoid it as much as possible. Comment on the findings of your study may be the focus of discussion.  Response: We thank the reviewers for their valuable insight. We have now revised the manuscript accordingly. We have shortened the evidence on goji berry and discussed the clinical implications of our results and limitations of the study  Conclusion:  Conclusions are not based on the results of the study. For example &quot;L.barbarum is a promising superfood with many potential health benefits&quot;, is not the conclusion of the study.  Response: We thank the reviewers for their valuable insight. We have revised the conlucsion and removed the line suggested above. &nbsp;  L. barbarum has been investigated as an adjunct to SRP. Negative control is missing in the study. Hence the results can't be attributed exclusively to L.barbarum.  Response: We thank the reviewers for their valuable insight and agree with fact that the results are due to the combined effects of SRP with goji berry mouthwash. Since SRP is primary and the fundamental step that should be performed and matched in both the group we aimed to compared goji berry mouthwash with chlorhexidine. We have added these points to our discussion as you have suggested.","URL":"https:\/\/f1000research.com\/articles\/12-302\/v4#referee-comment-10528","order":1,"name":"referee-comment-10528","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.168737.r299638, Francisco Wilker Mustafa Gomes Muniz, Graduate Program in Dentistry, Department of Periodontology, Universidade Federal de Pelotas, Pelotas, State of Rio Grande do Sul, 17 Jul 2024, version 3, 1 approved, 1 approved with reservations, 1 not approved","URL":"https:\/\/f1000research.com\/articles\/12-302\/v3#referee-response-299638","order":2,"name":"referee-response-299638","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.174704.r343647, Paulo Jos\u00e9 Lima Juiz, Federal University of Rec\u00f4ncavo da Bahia, Feira de Santana, 04 Dec 2024, version 4, indexed","URL":"https:\/\/f1000research.com\/articles\/12-302\/v4#referee-response-343647","order":3,"name":"referee-response-343647","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}