{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:06:26Z","timestamp":1772168786579,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.130056.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000}}],"reference-count":12,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Introduction<\/ns3:bold>\n                    Orbital lipoma is an extremely rare tumor, representing less than 1% of all orbital tumors. We review the literature and describe the presentation, the differential diagnosis and the management of this tumor.\n                    <ns3:bold>Case report<\/ns3:bold>\n                    We report the case of a 63-year-old patient who was referred for a diplopia with recent hemi-cranial headache. Physical examination showed no exophthalmos nor decrease in visual acuity. The patient complained of diplopia on elevation and oculomotricity examination showed limited elevation of the right eye. The Hess Lancaster test was in favor of a limited course of the right inferior rectus muscle. Magnetic resonance imaging revealed a fusiform tissue process in the right inferior rectus muscle with a fatty signal. A complete excision of the tumor was performed by a trasncunjonctival approach. Cytopathological examination was consistent with a pleomorphic lipoma. The postoperative period was uneventful. The definitive histopathologic diagnosis was a lipoma. The postoperative Magnetic resonance imaging showed the complete disappearance of the lesion. With 3 years of follow up, there is no sign of recurrence or ocular motility trouble.\n                    <ns3:bold>Conclusion:<\/ns3:bold>\n                    Lipomas are rare tumors in the orbit. The clinic is variable depending on the size and the site. The clinical diagnosis is difficult to make. Only histology allows the final diagnosis.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.130056.2","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T09:35:06Z","timestamp":1698399306000},"page":"700","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: an unusual orbital tumor"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-3081","authenticated-orcid":false,"given":"Anis","family":"Mahmoud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hager","family":"Touil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadima","family":"Hann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riadh","family":"Messaoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"442-444","DOI":"10.1007\/s10384-009-0679-2","article-title":"A case of orbital lipoma with exophtlmos and visual disturbance.","volume":"53","author":"M Chi","year":"2009","journal-title":"Jpn. J. Ophtalmol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"158-164","DOI":"10.1016\/j.neuchi.2010.02.007","article-title":"Tumeurs orbitaires d\u2019origine m\u00e9senchymateuse.","volume":"56","author":"T Civit","year":"2010","journal-title":"Neurochirurgie."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e53-e55","DOI":"10.1097\/IOP.0000000000000068","article-title":"Spindle cell lipoma of the orbit.","volume":"31","author":"D Tripathy","year":"2015","journal-title":"Ophthal. Plast. Reconstr. Surg."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e16-e18","DOI":"10.1097\/IOP.0b013e3181dee5fb","article-title":"Fibrolipoma of the orbit.","volume":"27","author":"M Kim","year":"2011","journal-title":"Ophthal. Plast. Reconstr. Surg."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"997-1008","DOI":"10.1016\/j.ophtha.2003.01.002","article-title":"Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 montgomery lecture, part 1.","volume":"111","author":"J Shields","year":"2004","journal-title":"Ophthalmology."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e53-e55","DOI":"10.1097\/IOP.0b013e31826a5112","article-title":"Diplopia from pleomorphic lipoma of the orbit with lateral rectus muscle involvement.","volume":"29","author":"F Toledano","year":"2013","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1251-1254","DOI":"10.2214\/ajr.181.5.1811251","article-title":"O'Connor MI. Imaging characteristics of spindle cell lipoma","volume":"181","author":"L Bancroft","year":"2003","journal-title":"AJR. Am. J. Roentgenol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"605-609","DOI":"10.1016\/0002-9394(85)90691-9","article-title":"Spindle cell lipoma of the orbit.","volume":"100","author":"G Bartley","year":"1985","journal-title":"Am. J. Ophtalmol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"419-423","DOI":"10.1016\/S0028-3843(14)60303-0","article-title":"Spindle cell lipoma of the orbit: acase report of an unusual orbital pathology.","volume":"44","author":"S Ulivieri","year":"2010","journal-title":"Neurol. Neurochir. Pol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"197-203","DOI":"10.1111\/j.1524-4725.1992.tb02797.x","article-title":"Case reports and review of the literature.","volume":"18","author":"F Digregorio","year":"1992","journal-title":"J. Dermatol. Surg. Oncol."},{"key":"ref11","first-page":"599-602","article-title":"Liposarcoma arising in the pharynx nine years after fibrolipoma excision.","volume":"112","author":"J Reibel","year":"1995","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"202-205","DOI":"10.1097\/IOP.0b013e318050ca52","article-title":"Orbital lipoma: 2 cases and review of literature.","volume":"23","author":"N Shah","year":"2007","journal-title":"Ophthal. Plast. Reconstr. Surg."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-700\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-700\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-700\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T02:45:11Z","timestamp":1715136311000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-700\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,27]]},"references-count":12,"URL":"https:\/\/doi.org\/10.12688\/f1000research.130056.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.158021.r263307","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.158021.r263307","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,27]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-700\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.142784.r190823, Mehdi Hasnaoui, Department of Otolaryngology-Head and Neck Surgery, Tahar Sfar Hospital, Mahdia, 04 Aug 2023, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/12-700\/v1#referee-response-190823","order":0,"name":"referee-response-190823","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Anis Mahmoud<\/b>; \n<i>Posted: 04 Aug 2023<\/i>; I would like to thank the reviewer for his interest in this work and will answer his queries in this report:  The MRI appearance of pleomorphic lipomas is variable and not pathognomonic for diagnosis, as the variation in the ratio of adipose to non-adipose components results in a wide spectrum of imaging features. MRI features such as hyper-vascularized tissue process and hypointense T1 and hyperintense T2 character can be explained by the presence of a high proportion of non-adipose elements in pleomorphic lipomas.  We have added a new reference (7) that also confirms our MRI results, which show the tumor to be hypointense in T1 and hyperintense in T2.  The expression &quot;trasncunjonctival&quot; has been replaced by &quot;transconjunctival&quot;.  Cytopathological&quot; has been replaced by &quot;histopathological&quot;.  The symptom &quot;hemi-cranial headache&quot; has been added to the &quot;case report&quot; section.","URL":"https:\/\/f1000research.com\/articles\/12-700\/v2#referee-comment-10029","order":1,"name":"referee-comment-10029","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.142784.r193958, Amira Trigui, Department of Ophthalmology, University of Sfax, Sfax, 16 Oct 2023, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/12-700\/v1#referee-response-193958","order":2,"name":"referee-response-193958","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.158021.r263307, Kirthi Koka, Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Sankara Nethralaya Medical Research Foundation, Chennai, Tamil Nadu, 08 May 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-700\/v2#referee-response-263307","order":3,"name":"referee-response-263307","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}