{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:56:09Z","timestamp":1787072169232,"version":"build-2736575974"},"update-to":[{"DOI":"10.12688\/f1000research.130251.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000}}],"reference-count":56,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"WHH Foundation"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background:<\/ns3:bold>\n                    Small intestine neuroendocrine tumors (SI-NETs), also called \u201ccarcinoids,\u201d are insidious tumors that are often metastatic when diagnosed. Limited studies on the mutational landscape of small bowel carcinoids indicate that these tumors have a relatively low mutational burden. The development of targeted therapies will depend upon the identification of mutations that drive the pathogenesis and metastasis of SI-NETs.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Methods:<\/ns3:bold>\n                    Whole exome and RNA sequencing of 5 matched sets of constitutional tissue, primary SI-NETs, and liver metastases were investigated. Germline and somatic variants included: single nucleotide variants (SNVs), insertions\/deletions (indels), structural variants, and copy number alterations (CNAs). The functional impact of mutations was predicted using Ensembl Variant Effect Predictor.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Results:<\/ns3:bold>\n                    Large-scale CNAs were observed including the loss of chromosome 18 in all 5 metastases and 3\/5 primary tumors. Certain somatic SNVs were metastasis-specific; including mutations in\n                    <ns3:italic>ATRX<\/ns3:italic>\n                    ,\n                    <ns3:italic>CDKN1B<\/ns3:italic>\n                    ,\n                    <ns3:italic>MXRA5<\/ns3:italic>\n                    (leading to the activation of a cryptic splice site and loss of mRNA),\n                    <ns3:italic>SMARCA2<\/ns3:italic>\n                    , and the loss of\n                    <ns3:italic>UBE4B<\/ns3:italic>\n                    . Additional mutations in\n                    <ns3:italic>ATRX<\/ns3:italic>\n                    , and splice site loss of\n                    <ns3:italic>PYGL<\/ns3:italic>\n                    , led to intron retention observed in primary and metastatic tumors.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusions:<\/ns3:bold>\n                    We observed novel mutations in primary\/metastatic SI-NET pairs, some of which have been observed in other types of neuroendocrine tumors. We confirmed previously observed phenomena such as loss of chromosome 18 and\n                    <ns3:italic>CDKN1B<\/ns3:italic>\n                    . Transcriptome sequencing added relevant information that would not have been appreciated with DNA sequencing alone. The detection of several splicing mutations on the DNA level and their consequences at the RNA level suggests that RNA splicing aberrations may be an important mechanism underlying SI-NETs.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.130251.2","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T11:40:09Z","timestamp":1696419609000},"page":"417","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Multiomic sequencing of paired primary and metastatic small bowel carcinoids"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-1283","authenticated-orcid":false,"given":"Mackenzie D.","family":"Postel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3395-894X","authenticated-orcid":false,"given":"Sourat","family":"Darabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5312-5972","authenticated-orcid":false,"given":"James R.","family":"Howe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie S.","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Demeure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"791-807","DOI":"10.4251\/wjgo.v12.i8.791","article-title":"Gastrointestinal neuroendocrine tumors in 2020.","volume":"12","author":"M Ahmed","year":"2020","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.3390\/cancers15082249","article-title":"Neuroendocrine Tumors: Genomics and Molecular Biomarkers with a Focus on Metastatic Disease.","volume":"15","author":"E Alexander","year":"2023","journal-title":"Cancers (Basel)."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2502-2508","DOI":"10.1172\/JCI67963","article-title":"The genomic landscape of small intestine neuroendocrine tumors.","volume":"123","author":"M Banck","year":"2013","journal-title":"J. Clin. Invest."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"63-71","DOI":"10.1097\/SLA.0b013e31818e4641","article-title":"Small bowel cancer in the United States: changes in epidemiology, treatment, and survival over the last 20 years.","volume":"249","author":"K Bilimoria","year":"2009","journal-title":"Ann. Surg."},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-22-0237","article-title":"Proteomic analysis of small intestinal neuroendocrine tumors and mesenteric fibrosis.","volume":"30","author":"A Bla\u017eevi\u0107","year":"2023","journal-title":"Endocr. Relat. Cancer."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2627-2631","DOI":"10.1182\/bloodadvances.2019000013","article-title":"Persistence of skewed X-chromosome inactivation in pre-B acute lymphoblastic leukemia of a female ATRX mutation carrier.","volume":"3","author":"C Bradley","year":"2019","journal-title":"Blood Adv."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"257-271","DOI":"10.1038\/nrg.2016.10","article-title":"Translating RNA sequencing into clinical diagnostics: opportunities and challenges.","volume":"17","author":"S Byron","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1110396","DOI":"10.3389\/fgene.2023.1110396","article-title":"Potential effective diagnostic biomarker in patients with primary and metastatic small intestinal neuroendocrine tumors.","volume":"14","author":"J Chen","year":"2023","journal-title":"Front. Genet."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/s41467-017-01355-0","article-title":"Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.","volume":"8","author":"J Cheng","year":"2017","journal-title":"Nat. Commun."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S1428-S1435","DOI":"10.1245\/s10434-014-4351-9","article-title":"Somatic Mutations and Genetic Heterogeneity at the CDKN1B Locus in Small Intestinal Neuroendocrine Tumors.","volume":"22","author":"J Crona","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"R275-R290","DOI":"10.1530\/EJE-15-0972","article-title":"GEP- NETS UPDATE: Genetics of neuroendocrine tumors.","volume":"174","author":"J Crona","year":"2016","journal-title":"Eur. J. Endocrinol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"82-94","DOI":"10.1002\/gcc.20834","article-title":"Common pathogenetic mechanism involving human chromosome 18 in familial and sporadic ileal carcinoid tumors.","volume":"50","author":"J Cunningham","year":"2011","journal-title":"Genes Chromosomes Cancer."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1335-1342","DOI":"10.1001\/jamaoncol.2017.0589","article-title":"Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States.","volume":"3","author":"A Dasari","year":"2017","journal-title":"JAMA Oncol."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e1673-e1682","DOI":"10.1210\/clinem\/dgaa924","article-title":"Plasmatic and Urinary 5-Hydroxyindolacetic Acid Measurements in Patients With Midgut Neuroendocrine Tumors: A GTE Study.","volume":"106","author":"L Mestier","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"R315-R334","DOI":"10.1530\/ERC-17-0012","article-title":"Genetic and epigenetic drivers of neuroendocrine tumours (NET).","volume":"24","author":"A Di Domenico","year":"2017","journal-title":"Endocr. Relat. Cancer."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"6367","DOI":"10.1038\/s41467-021-26581-5","article-title":"Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine.","volume":"12","author":"E Elias","year":"2021","journal-title":"Nat. Commun."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"27-33","DOI":"10.1159\/000520384","article-title":"A Rare Case of Simultaneous Pheochromocytoma Accompanied with an Ileocecal Neuroendocrine Tumor.","volume":"15","author":"K Eltawil","year":"2022","journal-title":"Case Rep. Oncol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1038\/ncomms4518","article-title":"Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.","volume":"5","author":"L Fernandez-Cuesta","year":"2014","journal-title":"Nat. Commun."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1483-1486","DOI":"10.1038\/ng.2821","article-title":"Somatic mutation of CDKN1B in small intestine neuroendocrine tumors.","volume":"45","author":"J Francis","year":"2013","journal-title":"Nat. Genet."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1186\/s12859-018-2486-6","article-title":"iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data.","volume":"19","author":"S Ge","year":"2018","journal-title":"BMC Bioinformatics."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/s12885-021-07978-3","article-title":"The association of sex-biased ATRX mutation in female gastric cancer patients with enhanced immunotherapy-related anticancer immunity.","volume":"21","author":"Y Ge","year":"2021","journal-title":"BMC Cancer."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"715-731","DOI":"10.1097\/MPA.0000000000000846","article-title":"The Surgical Management of Small Bowel Neuroendocrine Tumors: Consensus Guidelines of the North American Neuroendocrine Tumor Society.","volume":"46","author":"J Howe","year":"2017","journal-title":"Pancreas."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1199-1203","DOI":"10.1126\/science.1200609","article-title":"DAXX\/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.","volume":"331","author":"Y Jiao","year":"2011","journal-title":"Science."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"D545-D551","DOI":"10.1093\/nar\/gkaa970","article-title":"KEGG: integrating viruses and cellular organisms.","volume":"49","author":"M Kanehisa","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"3207-3213","DOI":"10.1245\/s10434-018-6676-2","article-title":"The Distal Predilection of Small Bowel Neuroendocrine Tumors.","volume":"25","author":"K Keck","year":"2018","journal-title":"Ann. Surg. Oncol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"29-36","DOI":"10.1097\/MPA.0000000000001707","article-title":"Racial Differences in Gastroenteropancreatic Neuroendocrine Tumor Treatment and Survival in the United States.","volume":"50","author":"E Kessel","year":"2021","journal-title":"Pancreas."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"490-504","DOI":"10.1159\/000508573","article-title":"Neuroendocrine Tumor Omic Gene Cluster Analysis Amplifies the Prognostic Accuracy of the NETest.","volume":"111","author":"M Kidd","year":"2021","journal-title":"Neuroendocrinology."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"591-603","DOI":"10.1002\/gcc.20561","article-title":"High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss.","volume":"47","author":"M Kulke","year":"2008","journal-title":"Genes Chromosomes Cancer."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1803-1808","DOI":"10.1016\/S0002-9440(10)64136-3","article-title":"Comparative genomic hybridization identifies loss of 18q22-qter as an early and specific event in tumorigenesis of midgut carcinoids.","volume":"158","author":"S Kyt\u00f6l\u00e4","year":"2001","journal-title":"Am. J. Pathol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"622693","DOI":"10.3389\/fendo.2021.622693","article-title":"Clinical Features, Management, and Molecular Characteristics of Familial Small Bowel Neuroendocrine Tumors.","volume":"12","author":"J Lim","year":"2021","journal-title":"Front. Endocrinol (Lausanne)."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"812-815","DOI":"10.1002\/ijc.1276","article-title":"Chromosome 18 deletions are common events in classical midgut carcinoid tumors.","volume":"92","author":"R L\u00f6llgen","year":"2001","journal-title":"Int. J. Cancer."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1830-1831","DOI":"10.1093\/bioinformatics\/btt285","article-title":"Pathview: an R\/Bioconductor package for pathway-based data integration and visualization.","volume":"29","author":"W Luo","year":"2013","journal-title":"Bioinformatics."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"210-216","DOI":"10.1038\/s41586-019-1689-y","article-title":"Pan-cancer whole-genome analyses of metastatic solid tumours.","volume":"575","author":"P Priestley","year":"2019","journal-title":"Nature."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13073-022-01083-1","article-title":"Whole genome sequencing reveals the independent clonal origin of multifocal ileal neuroendocrine tumors.","volume":"14","author":"N M\u00e4kinen","year":"2022","journal-title":"Genome Med."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"117-122","DOI":"10.1097\/01.sla.0000129342.67174.67","article-title":"Updated population-based review of carcinoid tumors.","volume":"240","author":"M Maggard","year":"2004","journal-title":"Ann. Surg."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"564-570","DOI":"10.1016\/j.cancergen.2015.08.003","article-title":"Somatic alterations of CDKN1B are associated with small bowel neuroendocrine tumors.","volume":"208","author":"J Maxwell","year":"2015","journal-title":"Cancer Genet."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"412-419","DOI":"10.1002\/humu.23939","article-title":"Utilizing RNA and outlier analysis to identify an intronic splice-altering variant in AP4S1 in a sibling pair with progressive spastic paraplegia.","volume":"41","author":"C McCullough","year":"2020","journal-title":"Hum. Mutat."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1502-1522","DOI":"10.1200\/JCO.1987.5.10.1502","article-title":"Karnofsky memorial lecture. An odyssey in the land of small tumors.","volume":"5","author":"C Moertel","year":"1987","journal-title":"J. Clin. Oncol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"302-312","DOI":"10.1159\/000446917","article-title":"Loss of Chromosome 18 in Neuroendocrine Tumors of the Small Intestine: The Enigma Remains.","volume":"104","author":"M Nieser","year":"2017","journal-title":"Neuroendocrinology."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1255-1269","DOI":"10.1634\/theoncologist.2008-0207","article-title":"Carcinoid tumors.","volume":"13","author":"S Pinchot","year":"2008","journal-title":"Oncologist."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"154-164","DOI":"10.1111\/jcmm.12953","article-title":"MXRA5 is a TGF-\u03b21-regulated human protein with anti-inflammatory and anti-fibrotic properties.","volume":"21","author":"J Poveda","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref36","article-title":"StatPearls.","author":"G Quinones","year":"2022"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"556-566","DOI":"10.1111\/his.14252","article-title":"Driver mutations occur frequently in metastases of well-differentiated small intestine neuroendocrine tumours.","volume":"78","author":"K Samsom","year":"2021","journal-title":"Histopathology."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"267-277","DOI":"10.2214\/AJR.18.19881","article-title":"Neuroendocrine Tumor Diagnosis and Management.","volume":"211","author":"Y Sanli","year":"2018","journal-title":"Am. J. Roentgenol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2339-2349","DOI":"10.1210\/clinem\/dgac162","article-title":"MEN4, the MEN1 mimicker; a case series of 3 phenotypically heterogenous patients with unique CDKN1B mutations.","volume":"107","author":"A Seabrook","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"869-877","DOI":"10.21037\/jgo.2019.05.02","article-title":"Survival trends of metastatic small intestinal neuroendocrine tumor: a population-based analysis of SEER database.","volume":"10","author":"C Shah","year":"2019","journal-title":"J. Gastrointest. Oncol."},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14051119","article-title":"Update on Epidemiology, Diagnosis, and Biomarkers in Gastroenteropancreatic Neuroendocrine Neoplasms.","volume":"14","author":"D Takayanagi","year":"2022","journal-title":"Cancers (Basel)."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"e0242780","DOI":"10.1371\/journal.pone.0242780","article-title":"Discovering novel driver mutations from pan-cancer analysis of mutational and gene expression profiles.","volume":"15","author":"H Tegally","year":"2020","journal-title":"PLoS One."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2741-2751","DOI":"10.1245\/s10434-020-09566-4","article-title":"The Landmark Series: Management of Small Bowel Neuroendocrine Tumors.","volume":"28","author":"C Tran","year":"2021","journal-title":"Ann. Surg. Oncol."},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092211","article-title":"The Multiple Facets of ATRX Protein.","volume":"13","author":"M Valenzuela","year":"2021","journal-title":"Cancers (Basel)."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1038\/s41598-018-22115-0","article-title":"Genetic heterogeneity of primary lesion and metastasis in small intestine neuroendocrine tumors.","volume":"8","author":"D Walter","year":"2018","journal-title":"Sci. Rep."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1367-1386","DOI":"10.1002\/cac2.12372","article-title":"Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract.","volume":"42","author":"H Wu","year":"2022","journal-title":"Cancer Commun (Lond)."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1797-1805","DOI":"10.1093\/carcin\/bgs210","article-title":"Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients.","volume":"33","author":"D Xiong","year":"2012","journal-title":"Carcinogenesis."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"3063-3072","DOI":"10.1200\/JCO.2007.15.4377","article-title":"One hundred years after \u201ccarcinoid\u201d: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States.","volume":"26","author":"J Yao","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"151-167","DOI":"10.1080\/14737159.2019.1665998","article-title":"Non-coding RNAs as biomarkers in liquid biopsies with a special emphasis on extracellular vesicles in urological malignancies.","volume":"20","author":"P Zeuschner","year":"2020","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"535-539","DOI":"10.1002\/gcc.22850","article-title":"Patterns of chromosome 18 loss of heterozygosity in multifocal ileal neuroendocrine tumors [published correction appears in Genes Chromosomes Cancer. 2022 Sep;61(9):579].","volume":"59","author":"Z Zhang","year":"2020","journal-title":"Genes Chromosomes Cancer."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-417\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-417\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-417\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T05:30:17Z","timestamp":1699421417000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-417\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,4]]},"references-count":56,"URL":"https:\/\/doi.org\/10.12688\/f1000research.130251.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.156060.r212103","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.156060.r212102","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.156060.r212103","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.156060.r212102","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,4]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-417\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.156060.r212103, Phillip Stafford, Department of Bioinformatics, Arizona State University, Tempe, Arizona, 19 Oct 2023, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-417\/v2#referee-response-212103","order":0,"name":"referee-response-212103","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.156060.r212102, Anela Bla\u017eevi\u0107, Erasmus MC Cancer Institute, Rotterdam, 08 Nov 2023, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-417\/v2#referee-response-212102","order":1,"name":"referee-response-212102","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported in part by a generous grant from the WHH Foundation.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}