{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T09:40:24Z","timestamp":1767174024443,"version":"build-2238731810"},"update-to":[{"DOI":"10.12688\/f1000research.130786.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000}}],"reference-count":53,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background:\u00a0<\/ns3:bold>\n                    Dental caries is a major non-communicable disease of public health concern caused due to freely available dietary sugars. We aimed to compare the sugar content and erosive potential with duration of use and drug classes of orodispersible tablets (ODTs).\u00a0\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Methods:\u00a0<\/ns3:bold>\n                    We conducted an\u00a0\n                    <ns3:italic>in vitro<\/ns3:italic>\n                    \u00a0evaluation of the total sugar content (TSC), Potential of Hydrogen (pH), solubility, and Titratable Acidity (TA) of commonly prescribed 62 ODTs. TA was measured by titrating the samples with known amount of. 0.1N sodium hydroxide (NaOH) with phenolphthalein indicator and pH was determined by digital pH meter. TSC was evaluated by phenol sulphuric acid. Solubility was assessed by filtration.\u00a0\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Results:\u00a0<\/ns3:bold>\n                    Out of the 62 ODTs, majority were Antimicrobials (n=30). One-quarter of the ODTs (26%) had a mean pH below \u22645.5. No significant difference was seen in the mean pH with respect to different drug classes (p=0.082) and duration of use of ODTs. A significant difference was seen in the mean percentage solubility with respect to drug classes (p&lt;0.001). Antimicrobials had the least percentage of solubility as compared to other drug classes. Antiemetics and proton pump inhibitors (24.33 \u00b1 17.34) had significantly higher mean percentage sugar content than Antimicrobials (23.25 \u00b1 17.16). No significant difference was seen in the mean TSC with respect to various drug classes (p=0.718) and between the duration of use of drugs (P=0.568) respectively.\u00a0No significant difference was seen in the mean percentage TA with respect to drug class (p=0.123) and duration of use of drugs (p=0.424).\n                    <ns3:bold>\u00a0<\/ns3:bold>\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusion:\u00a0<\/ns3:bold>\n                    Overall, we can conclude that one in four ODT formulations had a pH below 5.5 (critical pH).\u00a0 Only one ODT formulation did not have a sugar content. No difference was seen in the mean pH, sugar content, and TA with respect to duration of use of drugs and drug classes.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.130786.2","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T10:30:07Z","timestamp":1681295407000},"page":"228","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sugar content and erosive potential of commonly prescribed Orodispersible tablets- An in vitro study."],"prefix":"10.12688","volume":"12","author":[{"given":"Lahari","family":"Anand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5462-5677","authenticated-orcid":false,"given":"Kalyana","family":"Pentapati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-4824","authenticated-orcid":false,"given":"Revathi","family":"Shenoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-0982","authenticated-orcid":false,"given":"Geethika","family":"Yelleti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8863-6147","authenticated-orcid":false,"given":"Saurabh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/FROH.2022.764479","article-title":"Understanding dental caries as a non-communicable and behavioral disease: Management implications.","volume":"3","author":"R Giacaman","year":"2022","journal-title":"Frontiers. Oral Health."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"16-21","DOI":"10.1159\/000262131","article-title":"Dental health of children taking antimicrobial and non-antimicrobial liquid oral medication long-term.","volume":"30","author":"A Maguire","year":"1996","journal-title":"Caries Res."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-22268\/v1","article-title":"Cariogenic and erosive potential of liquid oral pediatric medicines of long-term use for children: an in vitro analysis.","author":"O Al-Batayneh","year":"2020"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.3390\/PHARMACEUTICS14081621","article-title":"Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of Nanostructure-Based Formulations.","volume":"14","author":"A Cornil\u0103","year":"2022","journal-title":"Pharmaceutics."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"156-161","DOI":"10.1111\/J.1600-0722.1996.TB00064.X","article-title":"Prevalence of dental erosion and the implications for oral health.","volume":"104","author":"J Nunn","year":"1996","journal-title":"Eur. J. Oral Sci."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"253-256","DOI":"10.14219\/JADA.ARCHIVE.1983.0239","article-title":"Dental erosion resulting from chewable vitamin C tablets.","volume":"107","author":"J Giunta","year":"1983","journal-title":"J. Am. Dent. Assoc."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"189-200","DOI":"10.1046\/j.1365-263X.2002.00360.x","article-title":"Is there a relationship between asthma and dental erosion? A case control study.","volume":"12","author":"Y Al-Dlaigan","year":"2002","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"22-27","DOI":"10.1590\/0103-6440201302344","article-title":"In Vitro Erosive Effect of Pediatric Medicines on Deciduous Tooth Enamel.","volume":"25","author":"C Scatena","year":"2014","journal-title":"Braz. Dent. J."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"261-270","DOI":"10.17135\/JDHS.2019.19.4.261","article-title":"Effect of Commercial Effervescent Vitamin Tablets on Bovine Enamel.","volume":"19","author":"M Jeong","year":"2019","journal-title":"J. Dent. Hyg. Sci."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"156-159","DOI":"10.1055\/s-0039-1697823","article-title":"Endogenous pH, Titratable Acidity and Total Soluble Solid Content of Mouthwashes Available in the Brazilian Market.","volume":"04","author":"A Cavalcanti","year":"2010","journal-title":"Eur. J. Dent."},{"key":"ref11","first-page":"433-437","article-title":"The implication of phenylketonuria on oral health.","volume":"21","author":"N Kilpatrick","year":"1999","journal-title":"Pediatr. Dent."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"118-119","DOI":"10.1023\/A:1011202409386","article-title":"The dental implications of chronic use of acidic medicines in medically compromised children.","volume":"23","author":"J Nunn","year":"2001","journal-title":"Pharm. World Sci."},{"key":"ref13","article-title":"CARIOGENIC AND EROSIVE POTENTIAL OF SOME LIQUID ORAL MEDICINES OF LONG TERM USE FOR EGYPTIAN CHILDREN.","volume":"61","author":"M Tawfik","year":"2015","journal-title":"Egypt. Dent. J."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"112-118","DOI":"10.1159\/000093358","article-title":"Oral hygiene products and acidic medicines.","volume":"20","author":"E Hellwig","year":"2006","journal-title":"Monogr. Oral Sci."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"143-146","DOI":"10.4103\/0970-4388.155129","article-title":"An in vitro analysis of the cariogenic and erosive potential of pediatric liquid analgesics.","volume":"33","author":"S Saeed","year":"2015","journal-title":"J. Indian Soc. Pedod. Prev. Dent."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2-7","DOI":"10.4103\/0250-474X.180244","article-title":"Oral Dispersible System: A New Approach in Drug Delivery System.","volume":"78","author":"P Hannan","year":"2016","journal-title":"Indian J. Pharm. Sci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"433-476","DOI":"10.1615\/CRITREVTHERDRUGCARRIERSYST.V21.I6.10","article-title":"Orally fast disintegrating tablets: developments, technologies, taste-masking and clinical studies.","volume":"21","author":"Y Fu","year":"2004","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"8-18","DOI":"10.1177\/0022034513508954","article-title":"Effect on caries of restricting sugars intake: systematic review to inform WHO guidelines.","volume":"93","author":"P Moynihan","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1017-1023","DOI":"10.1002\/J.0022-0337.2001.65.10.TB03444.X","article-title":"Sugar consumption and caries risk: a systematic review.","volume":"65","author":"B Burt","year":"2001","journal-title":"J. Dent. Educ."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"S881-S892","DOI":"10.1093\/AJCN\/78.4.881S","article-title":"Sugars and dental caries.","volume":"78","author":"R Touger-Decker","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"14-16","DOI":"10.1136\/bmj.2.6181.14","article-title":"Relation between medicines sweetened with sucrose and dental disease.","volume":"2","author":"I Roberts","year":"1979","journal-title":"BMJ."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"ZC78-ZC82","DOI":"10.7860\/JCDR\/2016\/18211.8024","article-title":"Comparison of Dental Caries Experience in Children Suffering From Epilepsy with and without Administration of Long Term Liquid Oral Medication.","volume":"10","author":"A Goyal","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"167","DOI":"10.24198\/pjd.vol31no3.25071","article-title":"Relationship between pediatric liquid medicines (PLMs) and dental caries in chronically ill children. Padjadjaran.","volume":"31","author":"A Goyal","year":"2019","journal-title":"J. Dent."},{"key":"ref24","first-page":"124-129","article-title":"Dental caries and sugar-containing liquid medicines for children in New Zealand.","volume":"93","author":"C Durward","year":"1997","journal-title":"N. Z. Dent. J."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"170-172","DOI":"10.1922\/CDH_2170Pomarico03","article-title":"Cariogenic and erosive potential of the medication used by HIV-infected children: pH and sugar concentration.","volume":"25","author":"L Pomarico","year":"2008","journal-title":"Community Dent. Health."},{"key":"ref26","first-page":"164-170","article-title":"pH, Titratable Acidity and Total Soluble Solid Content of Pediatric Antitussive Medicines.","volume":"42","author":"A Cavalcanti","year":"2008","journal-title":"Acta Stomatologica Croatica: International Journal of Oral Sciences and Dental Medicine."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"389-406","DOI":"10.1007\/978-3-319-45776-5_22","article-title":"pH and Titratable Acidity.","author":"C Tyl","year":"2017"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"350-356","DOI":"10.1021\/AC60111A017\/ASSET\/AC60111A017.FP.PNG_V03","article-title":"Colorimetric Method for Determination of Sugars and Related Substances.","volume":"28","author":"M Dubois","year":"1956","journal-title":"Anal. Chem."},{"key":"ref29","article-title":"Methods for measurement of solubility and dissolution rate of sparingly soluble drugs.","author":"J Larsson","year":"2009"},{"key":"ref30","doi-asserted-by":"publisher","article-title":"Evaluation of sugar content and erosive potential of commonly prescribed Orally Dispersible Tablets- An in vitro study.","year":"2023","DOI":"10.17632\/w5z857k3cw.2"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"5-9","DOI":"10.18773\/austprescr.2019.001","article-title":"Optimal antimicrobial duration for common bacterial infections.","volume":"42","author":"H Wilson","year":"2019","journal-title":"Aust. Prescr."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.3390\/pharmaceutics14081621","article-title":"Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of Nanostructure-Based Formulations.","volume":"14","author":"A Cornil\u0103","year":"2022","journal-title":"Pharmaceutics."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"759-763","DOI":"10.1007\/S12098-011-0543-5","article-title":"Erosive potential of sugar free and sugar containing pediatric medicines given regularly and long term to children.","volume":"79","author":"R Arora","year":"2012","journal-title":"Indian J. Pediatr."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"231-238","DOI":"10.1111\/J.1365-263X.2007.00826.X","article-title":"Are sugars-free medicines more erosive than sugars-containing medicines? An in vitro study of paediatric medicines with prolonged oral clearance used regularly and long-term by children.","volume":"17","author":"A Maguire","year":"2007","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1590\/PBOCI.2020.023","article-title":"Evaluation of sugar content and erosive potential of the commonly prescribed liquid oral medications.","volume":"20","author":"H Siddiq","year":"2020","journal-title":"Pesqui. Bras. Odontopediatria Clin. Integr."},{"key":"ref36","first-page":"317-320","article-title":"Evaluation of the cariogenic and erosive potential of pediatric liquid analgesics: An in-vitro study.","volume":"4","author":"K Soumya","year":"2016","journal-title":"Int. J. Curr. Pharm. Med. Res."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"115-118","DOI":"10.1038\/sj.bdj.4800037","article-title":"Dental erosion \u2014 the problem and some practical solutions.","volume":"186","author":"L Shaw","year":"1999","journal-title":"Br. Dent. J."},{"key":"ref38","first-page":"59-65","article-title":"Evaluation of the Erosive Potential of Various Pediatric Liquid Medicaments: An in-vitro Study.","volume":"6","author":"A Tupalli","year":"2014","journal-title":"J. Int. Oral Health."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"190-195","DOI":"10.5005\/jp-journals-10015-1436","article-title":"Comparative evaluation of the four most commonly used pediatric liquid formulations in Ahmedabad city: An in vitro study.","volume":"8","author":"V Shah","year":"2017","journal-title":"World J. Dentistry."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"14-20","DOI":"10.4103\/jpd.jpd_15_17","article-title":"Surface changes of primary tooth enamel by commonly used pediatric liquid medicaments: A scanning electron microscope study.","volume":"5","author":"S Mittal","year":"2017 undefined","journal-title":"J. Pediatr. Dent."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"247-254","DOI":"10.17219\/dmp\/91539","article-title":"Erosive and cariogenic potential of various pediatric liquid medicaments on primary tooth enamel: A SEM study.","volume":"55","author":"E Mahmoud","year":"2018","journal-title":"Dent. Med. Probl."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1590\/1807-2577.00622","article-title":"Cariogenic and erosive potential of pediatric medicines and vitamin supplements.","volume":"51","author":"L Coutinho","year":"2022","journal-title":"Rev. Odontol. UNESP."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"357-362","DOI":"10.17796\/jcpd.36.4.nt11584612462t84","article-title":"Cariogenic Potential of Pediatric Liquid Medicaments- An in vitro Study.","volume":"36","author":"P Subramaniam","year":"2012","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"486-489","DOI":"10.1590\/S0034-89102005000300022","article-title":"Sugar content in liquid oral medicines for children.","volume":"39","author":"K Peres","year":"2005","journal-title":"Rev. Saude Publica."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"132-137","DOI":"10.1590\/S1020-49892010000200007","article-title":"Sucrose concentration and pH in liquid oral pediatric medicines of long-term use for children.","volume":"27","author":"I Passos","year":"2010","journal-title":"Rev. Panam. Salud Publica."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3390\/pharmaceutics14040739","article-title":"Carbohydrates Used in Polymeric Systems for Drug Delivery: From Structures to Applications.","volume":"14","author":"X Di","year":"2022","journal-title":"Pharmaceutics."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"103-119","DOI":"10.1016\/S1383-5718(02)00128-6","article-title":"The comet assay with 8 mouse organs: Results with 39 currently used food additives.","volume":"519","author":"Y Sasaki","year":"2002","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"443-450","DOI":"10.1177\/000992289603500903","article-title":"Sweeteners, dyes, and other excipients in vitamin and mineral preparations.","volume":"35","author":"A Kumar","year":"1996","journal-title":"Clin. Pediatr. (Phila)."},{"key":"ref49","first-page":"722-724","article-title":"What is the critical pH and why does a tooth dissolve in acid?","volume":"69","author":"D Colin","year":"2003","journal-title":"J. Can. Dent. Assoc."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"137-142","DOI":"10.17796\/JCPD.33.2.Q5280T3744827V0H","article-title":"PH of medicated syrups--does it really matter?--An in-vitro study: Part-II.","volume":"33","author":"K Babu","year":"2008","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"138-142","DOI":"10.12691\/ijdsr-6-5-6","article-title":"Susceptibility of Human Deciduous Enamel to Erosive Wear after Exposure to Commonly Prescribed Oral Pediatric Liquid Medicaments: An AFM Based in vitro.","volume":"6","author":"S Feroz","year":"2018","journal-title":"ArticleDentalsciencesresearchCom."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"443-456","DOI":"10.1016\/S0011-8532(22)01740-2","article-title":"The role of medication and sugars in pediatric dental patients.","volume":"44","author":"L Bigeard","year":"2000","journal-title":"Dent. Clin. N. Am."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"587-596","DOI":"10.3945\/AN.117.015560","article-title":"A systematic review of the effects of polyols on gastrointestinal health and irritable bowel syndrome.","volume":"8","author":"A Lenhart","year":"2017","journal-title":"Adv. Nutr."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-228\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-228\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-228\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T22:45:13Z","timestamp":1730673913000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-228\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,12]]},"references-count":53,"URL":"https:\/\/doi.org\/10.12688\/f1000research.130786.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.130786.1","asserted-by":"subject"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,12]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-228\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.143566.r165215, Tarakant Bhagat, Department of Public Health Dentistry, College of Dental Surgery, B.P. Koirala Institute of Health Sciences, Dharan, 27 Mar 2023, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-228\/v1#referee-response-165215","order":0,"name":"referee-response-165215","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Kalyana Pentapati<\/b>; \n<i>Posted: 13 Apr 2023<\/i>; Query: In the results section, it is mentioned that a&nbsp;moderate significant negative correlation was seen between the pH and percentage TA, but the test used is not mentioned in the methods section.&nbsp;Please mention the name of the correlation test used in the relevant section.  Response: We have added the information in the statistical analysis section of the manuscript. \u201cCorrelation between pH and TA was evaluated using Spearman\u2019s rho.\u201d","URL":"https:\/\/f1000research.com\/articles\/12-228\/v2#referee-comment-9566","order":1,"name":"referee-comment-9566","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.143566.r165216, Harsh Priya, Division of Public Health Dentistry, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, Delhi, 04 Apr 2023, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-228\/v1#referee-response-165216","order":2,"name":"referee-response-165216","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Kalyana Pentapati<\/b>; \n<i>Posted: 13 Apr 2023<\/i>; Query: The mean TSC should not be expressed as percentage: \u201cThe total mean sugar content and percentage of sugar were 25.13%&plusmn;19.5 and 13.28%&plusmn;16.07, respectively (Table 2)\u201d  Response: Thank you. We have incorporated the change in the manuscript.  Query: The figure entered needs to be rechecked for antimicrobials: \u201cthe post-hoc test showed that Antiemetics and proton pump inhibitors (24.33%&plusmn;17.34) had significantly higher mean percentage sugar content than Antimicrobials (23.25%&plusmn;17.16).\u201d  Response: Thank you for highlighting the typo. We have incorporated the change in the manuscript. \u201cThe post-hoc test showed that Antiemetics and proton pump inhibitors (24.33%&plusmn;17.34) had significantly higher mean percentage sugar content than Antimicrobials (6.67%&plusmn;7.7).\u201d  Query: The pH number can be mentioned. This would help in better understanding the comparability: \u201cHowever, antimicrobials in liquid oral medications showed higher pH.\u201d  Response: Yes. Thank you. We have mentioned the same in the manuscript. (6.4 and 6.36)  Query: English correction is suggested for the following sentence, \u201cBuffering capacity and salivary flow rate can vary among individuals with the substantial influence of comorbidities, pre-existing caries, age, gender, hormonal levels, diet, and medications.\u201d  Response: We have revised the text in the manuscript. \u201cBuffering capacity and salivary flow rate can vary among individuals with a substantial influence of comorbidities, pre-existing caries, age, gender, hormonal levels, diet, and medications.\u201d  Query: A mention of confounding factors with suitable explanation is suggested.  Response: We have added this information. \u201cThe role of excipients and processing of ODTs can have substantial influence on the pH and sugar content. So ODTs of a particular drug may have different levels of pH and sugar content based on the dosage forms and can vary with different manufacturers. Hence, the current findings cannot be generalised to other similar available ODTs.\u201d  Query: Excipients can be further explained in the manuscript. The following reference can be helpful: Hannan&nbsp;\n<i>et al.,&nbsp;<\/i>(2016)\n<sup>1<\/sup>.  Response: We have added this information. \u201cExcipients in ODTs have a superdisintegrant, a bulking agent, a lubricant and swelling agent, a permeabilizing agent, sweeteners and flavorings agents which may have potential influence on the pH and sugar content of ODTs.\u201d  Query: Newer innovations are formulated for caries prevention due to ODTs\n<sup>2<\/sup>.&nbsp;  \n<b>References<\/b> 1. Hannan PA, Khan JA, Khan A, Safiullah S: Oral Dispersible System: A New Approach in Drug Delivery System. \n<i>Indian J Pharm Sci<\/i>. 2016;&nbsp;\n<b>78<\/b>&nbsp;(1): 2-7&nbsp;PubMed Abstract&nbsp;|&nbsp;Publisher Full Text 2. Kiniwa R, Miyake M, Kimura SI, Itai S, et al.: Development of muco-adhesive orally disintegrating tablets containing tamarind gum-coated tea powders for oral care.\n<i>Int J Pharm X<\/i>. 2019;&nbsp;\n<b>1<\/b>: 100012  Response: Thank you for your insight. These innovative products are yet to be proven for their effectiveness for caries prevention.","URL":"https:\/\/f1000research.com\/articles\/12-228\/v2#referee-comment-9567","order":3,"name":"referee-comment-9567","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}