{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:45:50Z","timestamp":1790250350200,"version":"4.1.0"},"update-to":[{"DOI":"10.12688\/f1000research.130932.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000}}],"reference-count":32,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Background Ashwagandha is a well-known Ayurvedic herb used for youthful vigor and wellbeing. This study investigated the effects of 600 mg standardized root extract (&gt;5% withanolides) of Ashwagandha (\n                    <ns3:italic>Withania somnifera<\/ns3:italic>\n                    ) on muscle size, strength and cardiorespiratory endurance following resistance training. Methods In this eight-week, parallel-group, multicenter, randomized, double-blind, placebo-controlled clinical study, 80 healthy male and female participants aged 18-45 years, who engaged in regular physical activity were randomly allocated in a 1:1 ratio to receive Ashwagandha (AG, n=40) 300 mg capsules twice daily for eight weeks, or identical placebo (PB, n=40). Seven (3 AG, 4 PB) participants were excluded due to poor compliance. All participants conducted eight-week resistance training. Study outcomes included muscle strength (1RM bench press and leg extension), muscle size\u00a0(circumference of arm, chest and upper thigh) and cardio-respiratory endurance\u00a0(VO2max) assessed at baseline and at eight weeks. Analysis of covariance (ANCOVA) was used to estimate adjusted differences based on sex, BMI and chest circumference at baseline. Results AG caused greater improvement in bench press (males: p = 0.0084; females: p = 0.0005), leg press (males: p = 0.0049; females: p = 0.018) and endurance (males: p &lt;0.0001; females: p &lt;0.0001) as compared to PB. Also, greater improvements in muscle girth for arm, chest and thigh were seen in both male and female participants with AG. No adverse events were reported in the study. Conclusions Eight weeks of AG root extract supplementation along with resistance training is effective in improving muscle strength, growth and endurance in both male and female participants. AG root extract could be a safer, effective and low-cost alternative for athletes to improve muscle endurance.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.130932.2","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T07:00:06Z","timestamp":1712559606000},"page":"335","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Ashwagandha (Withania somnifera) standardized root extract on physical endurance and VO2max in healthy adults performing resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study"],"prefix":"10.12688","volume":"12","author":[{"given":"Narsingh","family":"Verma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep Kumar","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1807-031X","authenticated-orcid":false,"given":"Sayali","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"498-505","DOI":"10.1136\/bjsports-2013-092952","article-title":"Position statement on youth resistance training: the 2014 International Consensus.","volume":"48","author":"R Lloyd","year":"2014 Apr","journal-title":"Br J Sports 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Verma","year":"2023","journal-title":"figshare."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-335\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-335\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-335\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T11:30:10Z","timestamp":1720697410000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-335\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,8]]},"references-count":32,"URL":"https:\/\/doi.org\/10.12688\/f1000research.130932.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.130932.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.163630.r287564","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.163630.r264045","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.163630.r264045","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.163630.r287564","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,8]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-335\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.163630.r264045, Mark E. T. Willems, Institute of Applied Sciences, College Lane, University of Chichester, Chichester, England, 22 Apr 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-335\/v2#referee-response-264045","order":0,"name":"referee-response-264045","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.143730.r200814, Nawab John Dar, School of Medicine, The University of Texas Health Science Center, San Antonio, Texas, 27 Nov 2023, version 1, 1 approved with reservations, 1 not approved","URL":"https:\/\/f1000research.com\/articles\/12-335\/v1#referee-response-200814","order":1,"name":"referee-response-200814","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>sayali patil<\/b>; \n<i>Posted: 02 Apr 2024<\/i>; Dear Nawab John Dar, Thank you for your time and valuable feedback on our manuscript. We have carefully reviewed your comments. As suggested, we provide a point-by-point response as below:  \n<i>The authors did not mention about the habits of the volunteers, what about their smoking habits and sleep cycle?<\/i>  \n<b>The two groups were similar with respect to the personal history and habits. A statement to that effect is added in the \u201csubjects\u201d section of the article (version 2).<\/b> &nbsp;  \n<i>Who manufactured the AG capsules and how did they made sure Quality of the capsules (QC&amp;QA), why would they buy the control and AG from different companies?<\/i>  \n<b>Control capsules were manufactured specifically for the study purpose and hence, it was outsourced to third party manufacturing. However, the study capsules (AG) were provided to manufacturer to match (identical placebo) the control (PB) capsules with AG.<\/b> &nbsp;  \n<i>I would love to know what happened to the endurance once the study is over and the volunteers stopped taking AG?<\/i>  \n<b>Follow-up was not a part of the study plan and we did not assess this.<\/b>","URL":"https:\/\/f1000research.com\/articles\/12-335\/v2#referee-comment-11363","order":2,"name":"referee-comment-11363","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.163630.r287564, Giuseppe Potrick Stefani, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Porto Alegre, 09 Jul 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-335\/v2#referee-response-287564","order":3,"name":"referee-response-287564","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}