{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:57:57Z","timestamp":1792634277154,"version":"4.5.0"},"update-to":[{"DOI":"10.12688\/f1000research.131461.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000}}],"reference-count":32,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Periodontal regeneration therapies frequently involve autologous platelet concentrates (APCs). They can be used in sinus lift surgeries and socket preservation, among other clinical settings. Platelet rich fibrin (PRF) membrane has been used to treat gingival recession in individuals or groups of individuals using a coronally progressed or lateral pedicle flap. In the treatment of mixed periodontic endodontic lesion\/furcation defect, PRF functions as a healing and interpositional biomaterial, filling a cystic cavity. PRF is known to help the bone regeneration process. In the last few years, efforts have been made to enhance the PRFs characteristics and quality. One of them is titanium platelet rich fibrin (T-PRF). Third-generation platelet concentrate no longer contains silica, and its preparation in glass vacuum containers, that no longer creates any known concerns. The effectiveness PRF\u2019s has been evaluated in connective tissue and bone repair. The aim of this study is to compare T-PRF to other platelet concentrates and different treatment modalities for periodontal regenerative procedures. Methods A protocol of this systematic review have been registered in prospero (CRD42022293545). The online database searched were PUBMED, COCHRANE for published articles up to November 2022 without language restrictions. Studies in trial registers, handsearching, bibliographic references of relevant articles were also checked. Data collection and analysis was done by individual authors. Independent eligibility assessments were conducted by four review authors. Then, using the standard Cochrane methodology, four review authors extracted the data and evaluated the risk of bias for individual studies. We developed \u201cSummary of findings\u201d tables and used GRADE to evaluate the evidence. Results Three studies were included for meta-analysis. Results of meta-analysis supported that T-PRF is effective for correction of both hard and soft tissue defects. Conclusions The overall qualitative and quantitative analysis suggest that T-PRF has superior structural properties and thicker fibrin network for ensuring predictable success periodontal regenerative procedures.<\/ns3:p>","DOI":"10.12688\/f1000research.131461.2","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T09:50:06Z","timestamp":1716544206000},"page":"393","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical efficacy of titanium prepared platelet rich fibrin in periodontal regeneration: A systematic review and meta-analysis"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-7070","authenticated-orcid":false,"given":"Dr. Ranu","family":"Oza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3127-3816","authenticated-orcid":false,"given":"Dr. Prasad","family":"Dhadse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-4811","authenticated-orcid":false,"given":"Dr. Pavan","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dr. Komal","family":"Bhombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5211-9156","authenticated-orcid":false,"given":"Dr. Khushboo","family":"Durge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5894-6286","authenticated-orcid":false,"given":"Dr. Chitrika","family":"Subhadarsanee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4313-2567","authenticated-orcid":false,"given":"Dr. Safiya","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"53-57","DOI":"10.4103\/2231-0746.83158","article-title":"Platelet-Rich fibrin: A second generation platelet concentrate and a new friend of oral and maxillofacial surgeons.","volume":"1","author":"H Saluja","year":"2011","journal-title":"Ann. 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Surg."},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.22341559.v1","author":"R Oza","year":"2023","journal-title":"figshare."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-393\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-393\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-393\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T02:20:12Z","timestamp":1726453212000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-393\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":32,"URL":"https:\/\/doi.org\/10.12688\/f1000research.131461.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.131461.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.163418.r282415","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.163418.r320559","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.163418.r320559","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.163418.r282415","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,24]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-393\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.144303.r178213, Anurag Satpathy, Department of Periodontics, Institute of Dental Sciences, Siksha O Anusandhan University, Bhubaneswar, Odisha, 27 Jun 2023, version 1, 2 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/12-393\/v1#referee-response-178213","order":0,"name":"referee-response-178213","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Ranu Oza<\/b>; \n<i>Posted: 08 May 2024<\/i>; Respected Sir, Thank you for your suggestions. Thank you for your constructive feedback on our manuscript. We have carefully considered your comments and made the following revisions:  \n<b>Introduction:<\/b> We have thoroughly modified and corrected the introduction to enhance clarity and coherence. \n<b>Objective Statement:<\/b> The objective statement for the systematic review is now explicitly mentioned in the main text, providing a clear overview of the study's aims. \n<b>Research Question and PICOT:<\/b> We have rephrased the research question and PICOT (Population, Intervention, Comparison, Outcome, Time) elements in a more concise and understandable manner. Additionally, we have included the PROSPERO registration number in this section for transparency. \n<b>PRISMA Checklist and Flow Diagram:<\/b> We have updated the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) Checklist to the 2020 version and included the updated Flow Diagram to accurately reflect our review process. \n<b>Results Section:<\/b> Due to the generation of forest plots and tables using Review Manager, we were unable to combine them into a single figure. However, we have ensured that both formats are presented clearly for better visualization and interpretation. \n<b>Description of Included Articles:<\/b> A concise description of the included articles has been added to provide readers with a brief overview of each study's characteristics.  We believe that these revisions have strengthened the manuscript and improved its overall quality.","URL":"https:\/\/f1000research.com\/articles\/12-393\/v2#referee-comment-11525","order":1,"name":"referee-comment-11525","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.163418.r282415, Sara Bernardi, Department\u00a0of\u00a0Life,\u00a0Health\u00a0and\u00a0Environmental\u00a0Sciences, University of L'Aquila, L\u2019Aquila, 11 Sep 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-393\/v2#referee-response-282415","order":2,"name":"referee-response-282415","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.163418.r320559, Sarah Al-Rihaymee, University of Babylon, Babylon, 16 Sep 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-393\/v2#referee-response-320559","order":3,"name":"referee-response-320559","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}