{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:51Z","timestamp":1772168871858,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.13171.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000}}],"reference-count":32,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001459","name":"Ministry of Education, Singapore","doi-asserted-by":"crossref","award":["RG136\/15 , RG 46\/12"],"award-info":[{"award-number":["RG136\/15 , RG 46\/12"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    The behavior of animals is intricately linked to the environment; a relationship that is often studied in laboratory conditions by using environmental perturbations to study biological mechanisms underlying the behavioral change.\u00a0\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    This study pertains to two such well-studied and well-replicated perturbations, i.e., stress-induced anxiogenesis and\n                    <ns4:italic>Toxoplasma<\/ns4:italic>\n                    <ns4:italic>gondii<\/ns4:italic>\n                    -induced loss of innate fear. Here, we demonstrate that behavioral outcomes of these experimental manipulations are contingent upon the ambient quality of the wider environment where animal facilities are situated.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    During late 2014 and early 2015, a building construction project started adjacent to our animal facility. During this phase, we observed that maternal separation stress caused anxiolysis, rather than historically observed anxiogenesis, in laboratory rats. We also found that\n                    <ns4:italic>Toxoplasma gondii<\/ns4:italic>\n                    infection caused an increase, rather than historically observed decrease, in innate aversion to predator odors in rats.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion:<\/ns4:bold>\n                    These observations suggest that effects of stress and\n                    <ns4:italic>Toxoplasma gondii<\/ns4:italic>\n                    are dependent on variables in the environment that often go unreported in the published literature.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.13171.2","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T05:00:19Z","timestamp":1516078819000},"page":"2097","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of stress or infection on rat behavior show robust 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.14287.r28765, Jaroslav Flegr, Department of Biology, Charles University in Prague, Prague, Czech Republic, 11 Dec 2017, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/6-2097\/v1#referee-response-28765","order":0,"name":"referee-response-28765","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Rupshi Mitra<\/b>; \n<i>Posted: 27 Dec 2017<\/i>; We thank reviewer for suggestions and comments. This has helped us to improve this manuscript during the revision. We have now submitted version 2 of this manuscript to the F1000Research.In the version 2, we have included a discussion of non-monotonic response of Toxoplasma in the introduction. We would also like to clarify that we tested stressed pups not their mothers. Pups were maternally deprived before weaning, allowed to reach adulthood and then tested.This has now been made clear during the revision.We have carefully checked and corrected all Latin names.","URL":"https:\/\/f1000research.com\/articles\/6-2097\/v2#referee-comment-3307","order":1,"name":"referee-comment-3307","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.14793.r29863, Terence Y. Pang, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic, Australia, 22 Jan 2018, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/6-2097\/v2#referee-response-29863","order":2,"name":"referee-response-29863","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was financially supported by Ministry of Education, Singapore (grant RG136\/15 and RG 46\/12). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}