{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:45:33Z","timestamp":1790527533080,"version":"4.1.0"},"reference-count":16,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>This case report presents the clinical evolution and management of a patient with a hereditary paraganglioma syndrome. This disease is characterized by rare tumors of neural crest origin that are symmetrically distributed along the paravertebral axis from the base of the skull and neck to the pelvis. In addition, these patients may develop renal cancer, gastrointestinal stromal tumors, pituitary adenomas, and bone metastasis in some cases. To date no successful therapeutic treatment has been reported. Total resection with postoperative radiotherapy and chemotherapy have been advocated, especially for the multiple metastasis. Here we show how the combination of high doses of the beta blocker propranolol (3 mg\/Kg\/day) and the DNA intercalating agent, temozolomide, has been successful in the treatment of a SDHA metastatic paraganglioma.<\/ns4:p>","DOI":"10.12688\/f1000research.13185.1","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T11:00:13Z","timestamp":1512385213000},"page":"2087","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Case Report: Propranolol increases the therapeutic response to temozolomide in a patient with metastatic paraganglioma"],"prefix":"10.12688","volume":"6","author":[{"given":"Miguel-Angel","family":"D\u00edaz-Castellanos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Villar","family":"G\u00f3mez de las 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Bioenerg."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"234-40","DOI":"10.1097\/PAS.0b013e3182671178","article-title":"Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation.","volume":"37","author":"M Miettinen","year":"2013","journal-title":"Am J Surg Pathol."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13023-015-0343-5","article-title":"Propranolol reduces viability and induces apoptosis in hemangioblastoma cells from von Hippel-Lindau patients.","volume":"10","author":"V Albi\u00f1ana","year":"2015","journal-title":"Orphanet J Rare Dis."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"41-53","DOI":"10.1160\/TH11-11-0809","article-title":"Propranolol as antiangiogenic candidate for the therapy of hereditary haemorrhagic telangiectasia.","volume":"108","author":"V Albi\u00f1ana","year":"2012","journal-title":"Thromb 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Attenuation of Cutaneous Angiosarcoma With Propranolol-Mediated \u03b2-Blockade.","volume":"151","author":"W Chow","year":"2015","journal-title":"JAMA dermatology."},{"key":"ref-15","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2908","article-title":"Propranolol for Off-label Treatment of Patients With Melanoma Results From a Cohort Study","author":"V De Giorgi","year":"2017","journal-title":"JAMA Oncol."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s13023-017-0664-7","article-title":"Repurposing propranolol as a drug for the treatment of retinal haemangioblastomas in von Hippel-Lindau disease.","volume":"12","author":"V Albi\u00f1ana","year":"2017","journal-title":"Orphanet J Rare 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