{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:06Z","timestamp":1772168886258,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.13206.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000}}],"reference-count":33,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Danderyds Hospital, Sweden"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Obesity, abdominal surgery, and intrathecal opioids are all factors associated with a risk for respiratory compromise. The aim of this explorative trial was to study the apnoea\/hypopnea index 1st postoperative night in obese mothers having had caesarean section (CS) in spinal anaesthesia with a combination of bupivacaine\/morphine and fentanyl.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    Consecutive obese (BMI &gt;30 kg\/m 2) mothers, \u226518 years, scheduled for CS with bupivacaine\/morphine\/fentanyl spinal anaesthesia were monitored with a portable polygraphy device Embletta \/NOX on 1\n                    <ns4:sup>st<\/ns4:sup>\n                    postoperative night. The apnoea\/hypopnea index (AHI) was identified by clinical algorithm and assessed in accordance to general guidelines; number of apnoea\/hypopnea episodes per hour: &lt;5 \u201cnormal\u201d, \u22655 and &lt;15\n                    <ns4:italic>mild sleep apnoea<\/ns4:italic>\n                    , \u226515 and &lt;30\n                    <ns4:italic>moderate sleep apnoea,<\/ns4:italic>\n                    \u2265 30\n                    <ns4:italic>severe sleep apnoea<\/ns4:italic>\n                    . Oxygen desaturation events were in similar manner calculated per hour as oxygen desaturation index (ODI).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    Forty mothers were invited to participate: 27 consented, 23 were included, but polysomnography registration failed in 3. Among the 20 mothers studied: 11 had an AHI &lt;5 (\n                    <ns4:italic>normal<\/ns4:italic>\n                    ), 7 mothers had AHI \u22655 but &lt;15 (\n                    <ns4:italic>mild OSAS<\/ns4:italic>\n                    ) and 2 mothers had AHI \u226515 (\n                    <ns4:italic>moderate OSA<\/ns4:italic>\n                    ), none had an AHI \u2265 30. The ODI was on average 4.4, and eight patients had an ODI &gt;5. Mothers with a high AHI (15.3 and 18.2) did not show high ODI. Mean saturation was 94% (91-96%), and four mothers had mean SpO\n                    <ns4:sub>2<\/ns4:sub>\n                    90-94%, none had a mean SpO2\u00a0&lt;90%.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion:<\/ns4:bold>\n                    Respiratory polygraphy 1\n                    <ns4:sup>st<\/ns4:sup>\n                    night after caesarean section in spinal anaesthesia with morphine in moderately obese mothers showed AHIs that in sleep medicine terms are considered normal, mild and moderate. Obstructive events and episodes of desaturation were commonly not synchronised. Further studies looking at preoperative screening for sleep apnoea in obese mothers are warranted but early postop respiratory polygraphy recording is cumbersome and provided sparse important information.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.13206.2","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T09:45:09Z","timestamp":1517996709000},"page":"2062","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Portable respiratory polygraphy monitoring of obese mothers the first night after caesarean section with bupivacaine\/morphine\/fentanyl spinal anaesthesia"],"prefix":"10.12688","volume":"6","author":[{"given":"Anette","family":"Hein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5829-1803","authenticated-orcid":false,"given":"Jan G.","family":"Jakobsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"437-44","DOI":"10.1097\/00000542-199902000-00018","article-title":"Dose-response relationship of intrathecal morphine for postcesarean analgesia.","volume":"90","author":"C Palmer","year":"1999","journal-title":"Anesthesiology."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"226-38","DOI":"10.1097\/ALN.0b013e3181c38c25","article-title":"Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression.","volume":"112","author":"A Dahan","year":"2010","journal-title":"Anesthesiology."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"956-61","DOI":"10.1213\/ane.0b013e318168b443","article-title":"Respiratory depression after neuraxial opioids in the obstetric setting.","volume":"107","author":"B Carvalho","year":"2008","journal-title":"Anesth Analg."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"1368-70","DOI":"10.1213\/ANE.0b013e3182a9b042","article-title":"A retrospective assessment of the incidence of respiratory depression after neuraxial morphine administration for postcesarean delivery analgesia.","volume":"117","author":"T Crowgey","year":"2013","journal-title":"Anesth Analg."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"133","DOI":"10.12688\/f1000research.10705.2","article-title":"Neuraxial opioids as analgesia in labour, caesarean section and hysterectomy: A questionnaire survey in Sweden [version 2; 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.15048.r30644, Lone Nikolajsen, Nina Stockfleth Buch, Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark, 12 Feb 2018, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/6-2062\/v2#referee-response-30644","order":0,"name":"referee-response-30644","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.15048.r30645, Patrick Thorton, Sunil Kumar Chauhan, Rotunda Hospital, Dublin, Ireland, 19 Feb 2018, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/6-2062\/v2#referee-response-30645","order":1,"name":"referee-response-30645","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study has been supported by the Department of Anaesthesia, Danderyds Hospital. No external grants have been received. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}