{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:39Z","timestamp":1772168859566,"version":"3.50.1"},"reference-count":5,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background:<\/ns3:bold>\n                    Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a very rare and a slowly conspicuous progressing chronic lung disease, which usually involves the upper lobes of the lung. This unusual disease, first recognized as a rare idiopathic interstitial pneumonia in 2013, is characterized by dense fibrosis of the visceral pleura and the subjacent lung parenchyma accompanied by elastosis predominating in the subpleural alveolar walls. In the interest of improving our understanding of this uncommon disease, we report a case of IPPFE established by pathology results.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Case report:<\/ns3:bold>\n                    A 73-year-old male patient, smoker, with a medical history of chronic obstructive pulmonary disease, presented since January 2022 with a gradual worsening of dyspnea on exertion and productive cough with weight loss. The chest X-ray detected a thoracic distention. The chest high resolution computed tomography revealed biapical subpleural parenchymatous condensations with tractive bronchiectasis and pleural retraction in the right upper lobe and diffuse bilateral cento-lobular emphysema. A scan-guided trans-parietal lung biopsy showed lung parenchyma tattooed with anthracosic deposits, largely remodeled by fibrous tissue, intermingled with numerous wavy and refractive dyselastotic structures in polarized light. The orcein staining confirmed the presence of excess elastosic fibers within these lesions. All etiological investigations were negative. His lung function studies revealed a reversible obstructive ventilatory disorder. Following a multidisciplinary discussion, the diagnosis of IPPFE was confirmed on the basis of the distribution in the upper lungs on chest computed tomography combined with pathology pattern.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusions:<\/ns3:bold>\n                    This case emphasizes the atypical misleading radiological presentation of IPPFE and the key role of pathological results in establishing the diagnosis. Hence, further studies are needed to improve our understanding of this uncommon disease and to establish clear-cut guidelines for IPPFE diagnosis and management.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.132553.1","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T10:00:05Z","timestamp":1693303205000},"page":"1048","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Idiopathic pleuroparenchymal fibroelastosis"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7732-8643","authenticated-orcid":false,"given":"Selsabil","family":"Daboussi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7752-0723","authenticated-orcid":false,"given":"Ben Hmida","family":"Lenda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Mhamedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boubaker","family":"Nouha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiraz","family":"Aichaouia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Ayadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zied","family":"Moatemri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1351-1359","DOI":"10.1513\/AnnalsATS.201902-181CME","article-title":"Pleuroparenchymal Fibroelastosis. A Review of Clinical, Radiological, and Pathological Characteristics.","volume":"16","author":"F Chua","year":"nov 2019","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"9-15","DOI":"10.1007\/s13665-017-0160-5","article-title":"Idiopathic Pleuroparenchymal Fibroelastosis.","volume":"6","author":"M Bonifazi","year":"2017","journal-title":"Curr. Pulmonol. Rep."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"432-440","DOI":"10.1097\/MCP.0000000000000907","article-title":"Pleuroparenchymal fibroelastosis.","volume":"28","author":"V Cottin","year":"1 sept 2022","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"300060521992217","DOI":"10.1177\/0300060521992217","article-title":"Idiopathic pleuroparenchymal fibroelastosis confirmed by pathology: a case report.","volume":"49","author":"M Cao","year":"f\u00e9vr 2021","journal-title":"J. Int. Med. Res."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"235-239","DOI":"10.14740\/jmc3927","article-title":"Idiopathic Pleuroparenchymal Fibroelastosis.","volume":"13","author":"K Tavakolian","year":"mai 2022","journal-title":"J. Med. Cases."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-1048\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1048\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1048\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T05:25:12Z","timestamp":1721193912000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-1048\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,29]]},"references-count":5,"URL":"https:\/\/doi.org\/10.12688\/f1000research.132553.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.145483.r286245","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.145483.r291326","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.145483.r286245","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.145483.r291326","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,29]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-1048\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.145483.r286245, Dongmei Zhou, Xuzhou Medical University,, Xuzhou City, Jiangsu Province,, 01 Jul 2024, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1048\/v1#referee-response-286245","order":0,"name":"referee-response-286245","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.145483.r291326, Claudia Valenzuela, Pulmonology Department, Universidad Aut\u00f3noma de Madrid, Madrid, 17 Jul 2024, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1048\/v1#referee-response-291326","order":1,"name":"referee-response-291326","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}