{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:06:54Z","timestamp":1772168814426,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.133438.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000}}],"reference-count":11,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Gonadotropinoma is the most common non-functional pituitary adenoma comprising 10%\u201330% of all pituitary adenomas. They are benign slow-growing tumours originating from adenohypophysis and rarely become malignant. Its presentation can be atypical, such as visual disturbance, and most patients presenting to an ophthalmologist for visual correction are eventually found to have a field defect. Here, we report a case of a 59-year-old patient who presented with a left-sided visual disturbance, which progressed over the years due to a left temporal hemianopia. The patient was referred to us by an ophthalmologist and was diagnosed with a giant non-functional gonadotropinoma. The patient was surgically treated. Postoperative follow-up magnetic resonance imaging after 3 months showed near complete resection of the tumour.<\/ns4:p>","DOI":"10.12688\/f1000research.133438.2","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T09:15:55Z","timestamp":1694682955000},"page":"674","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Atypical presentation of non-functional gonadotropinoma"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4383-1587","authenticated-orcid":false,"given":"Suresh","family":"Oommen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"377-382","DOI":"10.1111\/j.1365-2265.2009.03667.x","article-title":"Prevalence of pituitary adenomas: a community-based, cross-sectional study in Banbury (Oxfordshire, UK).","volume":"72","author":"A Fernandez","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"339-348","DOI":"10.1055\/s-2002-36708","article-title":"Gonadotropinomas.","volume":"20","author":"S Chaidarun","year":"2002","journal-title":"Semin. Reprod. Med."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1530\/EDM-18-0123","article-title":"A clinically functioning gonadotroph adenoma presenting with abdominal pain, ovarian hyperstimulation and fibromatosis.","volume":"2018","author":"C Broughton","year":"2018","journal-title":"Endocrinol. Diabetes Metab. Case Rep."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"756069","DOI":"10.1155\/2015\/756069","article-title":"Clinical characteristics and treatment outcome of 485 patients with nonfunctioning pituitary macroadenomas.","volume":"2015","author":"G Vargas","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"735-740","DOI":"10.1016\/j.jocn.2014.01.005","article-title":"Visual acuity and pattern of visual field loss at presentation in pituitary adenoma.","volume":"21","author":"S Ogra","year":"2014","journal-title":"J. Clin. Neurosci."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"894-904","DOI":"10.1210\/jc.2010-1048","article-title":"Pituitary incidentaloma: an endocrine society clinical practice guideline.","volume":"96","author":"P Freda","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"113-116","DOI":"10.1007\/978-3-319-29043-0_16","author":"F Bonneville","year":"2016","journal-title":"MRI of the pituitary gland."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"E533-E535","DOI":"10.1227\/NEU.0000000000001389","article-title":"Congress of neurological surgeons systematic review and evidence-based guideline on primary management of patients with nonfunctioning pituitary adenomas.","volume":"79","author":"J Lucas","year":"2016","journal-title":"Neurosurgery."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"75-76","DOI":"10.1215\/S1152851703200053","article-title":"Management of Pituitary Tumors: The Clinician\u2019s Practical Guide, 2nd edition.","volume":"6","author":"I Mccutcheon","year":"2004","journal-title":"Neuro-Oncology."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"117-122","DOI":"10.1159\/000094725","article-title":"Hyponatremia after Transsphenoidal Surgery for Hypothalamo-Pituitary Tumors.","volume":"83","author":"A Sata","year":"2006","journal-title":"Neuroendocrinology."},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.7927437","article-title":"Atypical presentation of non-functional gonadotropinoma.","author":"S Oommen","year":"2023","journal-title":"Zenodo."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-674\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-674\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-674\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T09:15:58Z","timestamp":1694682958000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-674\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,14]]},"references-count":11,"URL":"https:\/\/doi.org\/10.12688\/f1000research.133438.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.155757.r206552","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.155757.r206553","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,14]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-674\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.146428.r181637, Robinson George, Department of General Surgery, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, Kerala, 14 Jul 2023, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-674\/v1#referee-response-181637","order":0,"name":"referee-response-181637","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.146428.r195186, Atul Kalhan, Department\u00a0of\u00a0Diabetes\u00a0and\u00a0Endocrinology, Royal\u00a0Glamorgan\u00a0Hospital, Llantrisant, 06 Sep 2023, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-674\/v1#referee-response-195186","order":1,"name":"referee-response-195186","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}