{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:06:45Z","timestamp":1772168805481,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.134221.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000}},{"DOI":"10.12688\/f1000research.134221.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000}}],"reference-count":23,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Background Undescended testes (UDT) is a condition where one or both testes is absent in the scrotum. The general age recommendation in which the treatment should be performed is before 18 months old due to the infertility risk and malignancy in later life. In post-pubertal UDT, the current guideline recommends orchiectomy; however, the strength rating of this recommendation is weak. Therefore, this study aimed to provide a systematic review of post-pubertal UDT treatment, focusing on the malignancy risk point of view. Methods A systematic search was performed using PubMed, Wiley Online Library and the Cochrane Library up to 5 March 2023. Any study with either post-pubertal orchiectomy or orchidopexy in patients with UDT and reporting the testicular malignancy was included. The exclusion criteria were studies with lack of information of UDT correction time, no history of correction and the full text wasn\u2019t available. The data collected were the occurrence of testicular malignancy in post-pubertal UDT patients corrected with any method. Quality and bias assessment was assessed with Newcastle-Ottawa scale and Joanna Briggs Institute tools. Results Seven articles (three case reports and four observational studies) were reviewed with a total of 42 patients who underwent post-pubertal correction of either unilateral or bilateral UDT. The correction age ranged from 13 to 34 years old, with follow-up of 48.7\u2013252 months. Among those who developed malignancies, the most common were seminoma, teratoma and carcinoma\n                    <ns3:italic>in situ<\/ns3:italic>\n                    of the testes. In addition, this study was able to propose an algorithm for post-pubertal UDT treatment strategy. Conclusions The scarce resource was the main limitation of this study. Nevertheless, this review showed that post-pubertal UDT management should be tailored individually. Several factors that should be considered include the condition of the contralateral descended testis, UDT location, serum testosterone level, patient\u2019s age, comorbidities, and interest in fertility.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.134221.3","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T12:25:08Z","timestamp":1731500708000},"page":"1226","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Post-pubertal management of undescended testes from the malignancy risk point of view: a systematic review"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-1138","authenticated-orcid":false,"given":"William","family":"Tendi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4951-2827","authenticated-orcid":false,"given":"Putu Angga Risky","family":"Raharja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan","family":"Wahyudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arry","family":"Rodjani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard Reinaldi","family":"Situmorang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"ref3","doi-asserted-by":"publisher","first-page":"667-677","DOI":"10.5114\/aoms.2016.59940","article-title":"Undescended testis - current trends and guidelines: a review of the literature.","volume":"12","author":"J Niedzielski","year":"2016 Jun 1","journal-title":"Arch. 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Thank you for your kind review. We have added a line number for the next version of the article submitted  2. Thank you for your kind review. The asterisks were from the original template of the PRISMA guideline from the website, meaning to guide the authors about how to fill the boxes from the template. We have removed the asterisks  3. Thank you for your kind comment, we have revised the sentence accordingly  4. Thank you for our kind comment, we have revised the manuscript accordingly  5. The sentence &quot;to the best of the author's knowledge&quot; means to specify that prior to the publication of the manuscript, there has been no systematic review or meta-analysis that provide the evidence or specific algorithm of the post-pubertal UDT treatment, at least to the best of our search in the various databases included in the study. Nevertheless, we have removed the sentence. Thank you for your kind comment","URL":"https:\/\/f1000research.com\/articles\/12-1226\/v3#referee-comment-12619","order":3,"name":"referee-comment-12619","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.168034.r327173, Rifat Burak Erg\u00fcl, Istanbul University, Istanbul, 18 Oct 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1226\/v2#referee-response-327173","order":4,"name":"referee-response-327173","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":5,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}