{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:51:42Z","timestamp":1792003902583,"version":"4.4.0"},"update-to":[{"DOI":"10.12688\/f1000research.134667.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000}}],"reference-count":7,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Background The spirochaete\n                    <ns3:italic>Treponema pallidum subsp. pallidum<\/ns3:italic>\n                    , which causes the infectious disease syphilis, can be spread through sexual contact or perinatal transmission. In recent years, cases of syphilis have increased, especially among individuals engaging in behaviour that makes them more vulnerable (condomless sex and multiple sexual partners). Condylomata acuminata (external genital warts) is one of the most common viral sexually transmitted infections (STIs). Individuals who are behaviourally vulnerable are also highly prone to two or more STIs. Our case exemplifies the occurrence of two STIs in a young man who was behaviourally vulnerable to acquiring STIs. Case We report a case of a 21-year-old year old heterosexual man presenting with concomitant primary syphilis and genital warts. He presented with a painless genital ulcer and warty growths on his glans penis. Examination showed a painless indurated ulcer and multiple genital warts. Serology was positive for quantitative Venereal disease research laboratory test (1:16 titre). The patient was diagnosed with two concomitant STIs. He was treated as per the latest Centers for Disease Control and Prevention (CDC) guidelines for primary syphilis and podophyllin resin for genital warts. After four weeks, the genital ulcer showed complete healing and there was a significant reduction of genital warts. Conclusions Individuals with multiple sexual partners engaging in sexual activity without the use of prevention tools are at a greater chance of acquiring two or more STIs. To reduce concomitant transmission, preventive measures against genital ulcer diseases like syphilis, herpes, and chancroid, such as early identification and treatment, and condom distribution, must be strengthened as part of national STI prevention. Patients with two or more STIs should be followed regularly to assess the progress of infection and should be offered timely medical treatment.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.134667.2","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T11:25:10Z","timestamp":1718191510000},"page":"706","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Concomitant presence of two STIs in a male patient"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6484-5844","authenticated-orcid":false,"given":"Kaveri","family":"Rusia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhushan","family":"Madke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6270-5299","authenticated-orcid":false,"given":"Yash","family":"Kashikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"ref1","first-page":"25-36","article-title":"Genital warts: a comprehensive review.","volume":"5","author":"V Yanofsky","year":"2012","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"157-165","DOI":"10.1016\/j.det.2006.01.009","article-title":"Human papillomaviruses and genital disease.","volume":"24","author":"A Ahmed","year":"2006","journal-title":"Dermatol. Clin."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"574806","DOI":"10.3389\/fcimb.2020.574806","article-title":"Laboratory diagnostic tools for syphilis: current status and future prospects.","volume":"10","author":"Y Luo","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"17073","DOI":"10.1038\/nrdp.2017.73","article-title":"Benzaken. AS. Syphilis.","volume":"3","author":"R Peeling","year":"2017","journal-title":"Nat. Rev. Dis. Primers."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1006-1019","DOI":"10.1111\/jdv.15570","article-title":"Position statement for the diagnosis and management of anogenital warts.","volume":"33","author":"C O'Mahony","year":"2019 Jun","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e027438","DOI":"10.1136\/bmjopen-2018-027438","article-title":"Factors associated with HPV and other self-reported STI coinfections among sexually active Brazilian young adults: cross-sectional nationwide study.","volume":"9","author":"N Kops","year":"2019 Jun 1","journal-title":"BMJ Open."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.1002342","article-title":"Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysis.","volume":"10","author":"Y Wu","year":"2022 Jan 1","journal-title":"Front. Public Health."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-706\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-706\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-706\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T08:25:16Z","timestamp":1723796716000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-706\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":7,"URL":"https:\/\/doi.org\/10.12688\/f1000research.134667.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.134667.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.167723.r290390","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.167723.r310534","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.167723.r310534","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.167723.r290390","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.167723.r310539","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,12]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-706\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.167723.r290390, Electra Nicolaidou, 1st Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Athens, 03 Jul 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-706\/v2#referee-response-290390","order":0,"name":"referee-response-290390","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Kaveri Rusia<\/b>; \n<i>Posted: 09 Jul 2024<\/i>; Thank you for your response.&nbsp;  Author response Review Report Point 1: I have used podophyllin as it is easily available in our setting.  Author response Review Report Point 6: I have made the necessary changes in version 2 as suggested by you for comment 6.","URL":"https:\/\/f1000research.com\/articles\/12-706\/v2#referee-comment-11986","order":1,"name":"referee-comment-11986","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.147742.r266151, Alessandra Latini, San Gallicano Dermatological Institute IRCCS, Rome, 07 May 2024, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/12-706\/v1#referee-response-266151","order":2,"name":"referee-response-266151","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.167723.r310534, David \u0160majs, Eli\u0161ka Vrbov\u00e1, Department of Biology, Faculty of Medicine, Masaryk University, Brno, 16 Aug 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-706\/v2#referee-response-310534","order":3,"name":"referee-response-310534","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}