{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:20:15Z","timestamp":1790792415078,"version":"4.1.0"},"update-to":[{"DOI":"10.12688\/f1000research.134938.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000}}],"reference-count":26,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background<\/ns4:bold>\n                    : Acute pancreatitis (AP) is a common disorder and although most of the cases are mild, the mortality risk is high when it comes to severe AP. It is therefore important to determine the severity of AP as early as possible. This review aimed to determine the prognostic value of C-reactive protein-to-albumin ratio (CRP\/alb ratio) in patients with AP.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods<\/ns4:bold>\n                    : We performed a systematic search on the electronic databases PubMed, Science Direct, and Cochrane Library up to January 2023. Studies reporting CRP\/alb ratio on admission and its association with severity or mortality in AP patients were included. We calculated pooled mean difference (MD) and their 95% confidence intervals (CI) using a random-effects model. Quality assessment of the included studies was appraised using a Newcastle\u2013Ottawa scale.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results<\/ns4:bold>\n                    : A total of six studies comprising 2244 patients were included in this meta-analysis. Severe AP had higher CRP\/alb ratio on admission than mild-moderate AP (pooled MD: 3.59; 95% CI: 2.51-4.68; p&lt;0.00001). CRP\/alb ratio was also significantly higher on non-survivor AP patients compared to survivor AP patients (pooled MD: 2.12; 95% CI: 0.43-3.8; p &lt; 0.01).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion<\/ns4:bold>\n                    : High CRP\/alb ratio can be used as an early predictor of poor prognosis in patients with AP.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.134938.2","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T06:50:16Z","timestamp":1695365416000},"page":"748","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic value of C-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9665-8082","authenticated-orcid":false,"given":"I Ketut","family":"Mariadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gde","family":"Somayana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1853-3310","authenticated-orcid":false,"given":"Christina Permata","family":"Shalim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4933-9446","authenticated-orcid":false,"given":"Dwijo Anargha","family":"Sindhughosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8698-1265","authenticated-orcid":false,"given":"Dian","family":"Daniella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Made Lady Adelaida","family":"Purwanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13017-019-0247-0","article-title":"2019 WSES guidelines for the management of severe acute pancreatitis.","volume":"14","author":"A Lepp\u00e4niemi","year":"2019 Jun 13","journal-title":"World J. Emerg. Surg."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"101060","DOI":"10.1016\/j.accpm.2022.101060","article-title":"Guidelines for the management of patients with severe acute pancreatitis, 2021.","volume":"41","author":"S Jaber","year":"2022 Jun 1","journal-title":"Anaesth. Crit. Care Pain Med."},{"key":"ref3","article-title":"The global, regional, and national burden of acute pancreatitis in 204 countries and territories, 1990\u20132019","volume":"21","author":"C Li","year":"2021","journal-title":"BMC Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3390\/ijms21010338","article-title":"Multifactorial Scores and Biomarkers of Prognosis of Acute Pancreatitis: Applications to Research and Practice.","volume":"21","author":"P Silva-Vaz","year":"2020 Jan","journal-title":"Int. J. Mol. Sci."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12876-020-01318-8","article-title":"Evaluation of four scoring systems in prognostication of acute pancreatitis for elderly patients.","volume":"20","author":"Y Li","year":"2020 Jun 1","journal-title":"BMC Gastroenterol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-Reactive Protein at Sites of Inflammation and Infection.","volume":"9","author":"N Sproston","year":"2018 Apr 13","journal-title":"Front. Immunol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"713-722.e7","DOI":"10.1016\/j.amjmed.2019.10.031","article-title":"Relationship of Nutritional Status, Inflammation, and Serum Albumin Levels During Acute Illness: A Prospective Study.","volume":"133","author":"A Eckart","year":"2020 Jun 1","journal-title":"Am. J. Med."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1785-1805","DOI":"10.1177\/0962280216669183","article-title":"Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range.","volume":"27","author":"D Luo","year":"2018 Jun","journal-title":"Stat. Methods Med. Res."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range.","volume":"14","author":"X Wan","year":"2014 Dec 19","journal-title":"BMC Med. Res. Methodol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"129-135","DOI":"10.4149\/BLL_2022_020","article-title":"Comparison of the predictive values of CRP, CRP\/albumin, RDW, neutrophil\/lymphocyte, and platelet\/lymphocyte levels in determining the severity of acute pancreatitis in patients with acute pancreatitis according to the BISAP score.","volume":"123","author":"B Karabuga","year":"2022","journal-title":"Bratisl. Lek. Listy."},{"key":"ref11","first-page":"81-87","article-title":"Comparison of the Efficacy of Balthazar Score and C-Reactive Protein-Albumin Ratio for Determination of Acute Pancreatitis Severity.","volume":"48","author":"M Kiyak","year":"2022","journal-title":"Curr. Health Sci. J."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"7514-7521","DOI":"10.26355\/eurrev_202210_30022","article-title":"The effect of procalcitonin and immature granulocyte ratio in predicting the development of acute necrotizing pancreatitis: evidence from 582 cases.","volume":"26","author":"E Ugurlu","year":"2022 Oct","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"528-531","DOI":"10.5505\/tjtes.2018.98583","article-title":"Significance of red blood cell distribution width and C-reactive protein\/albumin levels in predicting prognosis of acute pancreatitis.","volume":"24","author":"E Y\u0131lmaz","year":"2018 Nov","journal-title":"Ulus Travma Ve Acil Cerrahi Derg. Turk. J. Trauma Emerg. Surg. TJTES."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1186\/s12893-020-00991-6","article-title":"Prognostic value of the creatinine-albumin ratio in acute pancreatitis debridement.","volume":"20","author":"Z Zhao","year":"2020 Dec 9","journal-title":"BMC Surg."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1026604","DOI":"10.3389\/fsurg.2022.1026604","article-title":"Predictive value of the C-reactive protein\/albumin ratio in severity and prognosis of acute pancreatitis.","volume":"9","author":"Y Zhao","year":"2022","journal-title":"Front. Surg."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2008-2023","DOI":"10.1053\/j.gastro.2018.12.041","article-title":"Organ Failure due to Systemic Injury in Acute Pancreatitis.","volume":"156","author":"P Garg","year":"2019 May","journal-title":"Gastroenterology."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"102-111","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus.","volume":"62","author":"P Banks","year":"2013 Jan","journal-title":"Gut."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"874-880","DOI":"10.1016\/j.hpb.2017.06.001","article-title":"The predictive value of C-reactive protein (CRP) in acute pancreatitis \u2013 is interval change in CRP an additional indicator of severity?","volume":"19","author":"A Stirling","year":"2017 Oct 1","journal-title":"HPB."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"737155","DOI":"10.3389\/fonc.2021.737155","article-title":"Prognostic Role of the C-Reactive Protein\/Albumin Ratio in Patients With Gynecological Cancers: A Meta-Analysis.","volume":"11","author":"Y Fang","year":"2021 Oct 28","journal-title":"Front. Oncol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12957-021-02253-y","article-title":"Prognostic value of the C-reactive protein to albumin ratio in colorectal cancer: an updated systematic review and meta-analysis.","volume":"19","author":"C Liao","year":"2021 May 1","journal-title":"World J. Surg. Oncol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3390\/jcm7100333","article-title":"The C-Reactive Protein\/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients.","volume":"7","author":"J Park","year":"2018 Oct","journal-title":"J. Clin. Med."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1-9","DOI":"10.1155\/2021\/9957563","article-title":"Relationship between CRP Albumin Ratio and the Mortality in Critically Ill Patients with AKI: A Retrospective Observational Study.","volume":"2021","author":"J Wang","year":"2021 Sep 30","journal-title":"Biomed. Res. Int."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e29243","DOI":"10.7759\/cureus.29243","article-title":"Use of the C-Reactive Protein (CRP)\/Albumin Ratio as a Severity Tool in Acute Pancreatitis: Systematic Review.","volume":"14","author":"M Tarar","year":"2022","journal-title":"Cureus."},{"key":"ref24","first-page":"2387-94","article-title":"Comparison of scoring systems in predicting the severity of acute pancreatitis.","volume":"21","author":"J Cho","year":"2015","journal-title":"World J. Gastroenterol. WJG"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"127-31","DOI":"10.1093\/gastro\/gox029","article-title":"A comparison of APACHE II, BISAP, Ranson\u2019s score and modified CTSI in predicting the severity of acute pancreatitis based on the 2012 revised Atlanta Classification.","volume":"6","author":"A Harshit Kumar","year":"2018","journal-title":"Gastroenterol Rep."},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.8003368","article-title":"Prognostic value of C-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis (extended data).","author":"I Mariadi","year":"2023"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-748\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-748\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-748\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T06:30:15Z","timestamp":1696573815000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-748\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,22]]},"references-count":26,"URL":"https:\/\/doi.org\/10.12688\/f1000research.134938.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.156179.r208618","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.156179.r208619","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.156179.r208619","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.156179.r208618","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,22]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-748\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.156179.r208619, Hasan Maulahela, Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo National General Hospital, University of Indonesia, Depok, West Java, 06 Oct 2023, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-748\/v2#referee-response-208619","order":0,"name":"referee-response-208619","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.156179.r208618, Bogi Pratomo Wibowo, Faculty of Medicine, Brawijaya University, Malang, East Java, 03 Oct 2023, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-748\/v2#referee-response-208618","order":1,"name":"referee-response-208618","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}