{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:00Z","timestamp":1772168820715,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.134946.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000}},{"DOI":"10.12688\/f1000research.134946.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000}}],"reference-count":29,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Lymphomas of the oral and oropharyngeal regions are rather uncommon, and diagnosis can be challenging and confusing due to the multiple histological subgroups. Lymphomas are the third most common type of tumor in the head and neck region and are brought on by the lymphoreticular system. The two forms of lymphoma are Hodgkin\u2019s lymphoma and non-Hodgkin\u2019s lymphoma (NHL). Herein, we present a case report of oropharyngeal lymphoma. The female patient reported with a complaint of swelling over the palatal region for two to three months. An ulceroproliferative lesion was evident over the posterior palatal region. We diagnosed reactive lymphadenitis based on an incisional biopsy. To confirm the diagnosis and rule out other conditions, a punch biopsy followed by immunohistochemical studies were done. Features suggestive of activated B-cell-diffuse large B-cell lymphoma were confirmed. Among malignant lymphomas, diffuse large B-cell lymphoma is the most prevalent variety. Much progress has been made in recent years in understanding the molecular pathophysiology of this disease. In this case report, we aim to correlate the clinical presentation, histology features and immunohistochemical significance in order to promote early discovery, diagnosis, and treatment for a better prognosis of the patient.<\/ns3:p>","DOI":"10.12688\/f1000research.134946.3","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T11:25:24Z","timestamp":1722597924000},"page":"769","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Activated B-cell-diffuse large B-cell lymphoma"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-1643","authenticated-orcid":false,"given":"Padmashri","family":"Kalmegh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alka","family":"Hande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhuri","family":"Gawande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Patil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9225-7919","authenticated-orcid":false,"given":"Archana","family":"Sonone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0529-3856","authenticated-orcid":false,"given":"Aayushi","family":"Pakhale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"45-59","DOI":"10.1111\/bjh.15614","article-title":"Diagnosis of Hodgkin lymphoma in the modern era.","volume":"184","author":"H Wang","year":"2019 Jan","journal-title":"Br. 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No other laboratory test data is presented in the case report.  2. Yes, a few sub-centimetric to centimetric enlarged lymph nodes in bilateral submandibular, jugulo-digastric regions are seen.  3. Physical examination for lymph nodes at other sites including submental, submandibular, supraclavicular, and upper jugulodigastric regions was done.  4. Clinical differential diagnosis may include- Squamous cell carcinoma, Round cell tumor, Reactive lymphadenitis, Pleomorphic adenoma etc. Radiographic differential diagnosis may include - Oropharyngeal squamous cell carcinoma  5. No EBV-related staining was done. For molecular detection of EBV - immunohistochemistry CD45 and CD20 was done as mentioned before.  &nbsp;6. Learning objectives includes - There are many histological subtypes of lymphoma; therefore to differentiate and specify this presented rare subtype, case report would be useful.","URL":"https:\/\/f1000research.com\/articles\/12-769\/v3#referee-comment-10613","order":1,"name":"referee-comment-10613","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Padmashri Kalmegh<\/b>; \n<i>Posted: 01 Jul 2024<\/i>; \n<b>Comment 1<\/b> \u2013 Other laboratory investigations that were performed include a complete hemogram, hormonal profile, and immunohistochemistry. &nbsp;\n<b>Comment 2<\/b> - &nbsp;Lymph nodes in the left submandibular region were palpable, of size 1 &times; 2 cm, non-tender, and firm in texture. \n<b>Comment 3 &amp; 4\u2013 <\/b>Radiological differential diagnosis may include benign hyperplasia\n<b>, <\/b>salivary gland tumor, lymphadenopathy, and nasopharyngeal carcinoma. \n<b>Comment 5 - <\/b>there were no EBV-related alterations seen on pathological examinations \n<b>Comment 6 \u2013 <\/b>The presented case is rare and in this case report we have mentioned its clinical features, aetiology, histopathological features, and various IHC&nbsp; markers in detail that may be the addition to the knowledge of the reader.","URL":"https:\/\/f1000research.com\/articles\/12-769\/v3#referee-comment-11940","order":2,"name":"referee-comment-11940","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.148043.r288731, Soundarya Ravi, Departments of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 28 Jun 2024, version 1, 2 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/12-769\/v1#referee-response-288731","order":3,"name":"referee-response-288731","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Padmashri Kalmegh<\/b>; \n<i>Posted: 01 Jul 2024<\/i>; The corrections are as follows,  In the abstract age of the patient is added. In the abstract and case report site of the biopsy has been mentioned. The first line from the introduction is removed. Radiological findings are updated before histopathological findings. Removed the word \u2018atypical\u2019 from the histopathological findings. Morphological differential diagnosis is updated in the discussion section. 1\n<sup>st<\/sup> paragraph from the treatment is added to the discussion. Incidence of lymphoma in the oral cavity is added. Histopathological and CD45 IHC images are replaced. The role of the IHC marker in the diagnosis of NHL is added.   Clarifications Comment 2 \u2013 Although the site of the biopsy was from the palatal region, on microscopy it showed numerous atypical cells with pleomorphic features. Hence the diagnosis of reactive lymphadenitis was made. IHC was not performed for the initial biopsy. The initial biopsy was taken from OPD so we could not take photographs for the same. Comment 3 \u2013 The last line of the introduction is added as per the guidelines of the journal.","URL":"https:\/\/f1000research.com\/articles\/12-769\/v3#referee-comment-11939","order":4,"name":"referee-comment-11939","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.168733.r308227, Puneeta Vohra, SGT University, Gurugram, 31 Jul 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-769\/v2#referee-response-308227","order":5,"name":"referee-response-308227","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Padmashri Kalmegh<\/b>; \n<i>Posted: 31 Jul 2024<\/i>; Thank you for your comments","URL":"https:\/\/f1000research.com\/articles\/12-769\/v3#referee-comment-12107","order":6,"name":"referee-comment-12107","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.168733.r308966, Dr. Akshay Dhobley, Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Nagpur, Maharashtra, 01 Aug 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-769\/v2#referee-response-308966","order":7,"name":"referee-response-308966","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":8,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}